scholarly journals Peroxisomal 2-Hydroxyacyl-CoA Lyase Is Involved in Endogenous Biosynthesis of Heptadecanoic Acid

Molecules ◽  
2017 ◽  
Vol 22 (10) ◽  
pp. 1718 ◽  
Author(s):  
Benjamin Jenkins ◽  
Evelyn de Schryver ◽  
Paul P. Van Veldhoven ◽  
Albert Koulman
Keyword(s):  
Heptadecanoic Acid

Determination of Myocardial FFA Elimination Rates by Functional Images of Uncorrected Half-Time Values

1984 ◽  
Vol 23 (06) ◽  
pp. 277-282 ◽  
Author(s):  
A. Van Lingen ◽  
G. Westera ◽  
M. van ◽  
W. Den Hollander ◽  
E. E. Van der Wall ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Regions Of Interest ◽  
Heptadecanoic Acid ◽  
Half Time ◽  
Alternative Method ◽  
Functional Images ◽  
Functional Image ◽  
Back Ground ◽  
Objective Determination

SummaryThis paper presents an alternative method of demarcating regions of in terest over the myocardium after ad ministration of 123I-heptadecanoic acid to patients with coronary artery disea se. In a matrix of 32 × 32 pixels the elimination rates of the radioactivity, which are not corrected for back ground activity, are visualized per pixel in a functional image. The func tional image showed areas in the myocardium with high values of uncorrected elimination rates. These areas corresponded with the tracer defects on the scintigram. Corrected elimination rates obtained from re gions of interest of functional images were comparable with those of scinti grams. Thus based on functional im ages of uncorrected elimination rates a reliable, objective determination of regions of interest over normal and abnormal myocardium can be made.

scholarly journals The effect of linseed oil supplementation of the diet on the content of fatty acids in the egg yolk

2012 ◽  
Vol 81 (2) ◽  
pp. 159-162 ◽  
Author(s):  
Petra Hudečková ◽  
Lucie Rusníková ◽  
Eva Straková ◽  
Pavel Suchý ◽  
Petr Marada ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Soybean Oil ◽  
Fatty Acid Profile ◽  
Myristic Acid ◽  
Linseed Oil ◽  
Control Group ◽  
Heptadecanoic Acid ◽  
Egg Yolks ◽  
Experimental Group

The aim of this study was to compare the effect of two different types of oils in diet on the fatty acid profile in the eggs of layers and to include a particular type of oil as a supplement of feeding mixtures for layers in order to support the development of functional foodstuffs. Thirty layers fed a diet containing soybean oil constituted the control group (soybean oil is the most frequently used oil added to feeding mixtures). In the experimental group (thirty layers), soybean oil was replaced with linseed oil at the same amount (3 kg of oil per 100 kg of feeding mixture). Feeding was provided ad libitum for all days of the month. After one month, egg yolks were analysed and the fatty acid profile was compared. Significant differences (P ≤ 0.05) were found in the concentration of myristic acid that belongs to the group of saturated fatty acids. Eggs in the experimental group showed higher concentrations of myristic acid compared to the control group (0.20 g/100 g of fat and 0.18 g/100 g of fat, respectively). Highly significant differences (P ≤ 0.01) were found for heptadecanoic acid but the trend was opposite to that of myristic acid; concentrations of heptadecanoic acid in the experimental group were lower than those in the control group. Highly significant differences (P ≤ 0.01) were found for n-9 monounsaturated fatty acids where egg yolks in eggs from layers fed linseed oil contained higher concentrations of oleic acid, myristoleic acid, and palmitoleic acid. Lower concentrations of n-6 fatty acids (P ≤ 0.01) were found after the addition of linseed oil in eggs. Linseed oil showed a positive effect on n-3 fatty acids (α-linolenic acid), its concentration in the control and experimental group was 0.82 g/100 g of fat and 5.63 g/100 g of fat, respectively. The possibility of influencing the fatty acid profile in eggs is very important for the development of functional foods.

scholarly journals Serial measures of circulating biomarkers of dairy fat and total and cause-specific mortality in older adults: the Cardiovascular Health Study

2018 ◽  
Vol 108 (3) ◽  
pp. 476-484 ◽  
Author(s):  
Marcia C de Oliveira Otto ◽  
Rozenn N Lemaitre ◽  
Xiaoling Song ◽  
Irena B King ◽  
David S Siscovick ◽  
...  
Keyword(s):  
Older Adults ◽  
Total Mortality ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Heptadecanoic Acid ◽  
Stroke Mortality ◽  
Dairy Fat ◽  
Specific Mortality ◽  
Cvd Mortality

ABSTRACT Background Controversy has emerged about the benefits compared with harms of dairy fat, including concerns over long-term effects. Previous observational studies have assessed self-reported estimates of consumption or a single biomarker measure at baseline, which may lead to suboptimal estimation of true risk. Objective The aim of this study was to investigate prospective associations of serial measures of plasma phospholipid fatty acids pentadecanoic (15:0), heptadecanoic (17:0), and trans-palmitoleic (trans-16:1n–7) acids with total mortality, cause-specific mortality, and cardiovascular disease (CVD) risk among older adults. Design Among 2907 US adults aged ≥65 y and free of CVD at baseline, circulating fatty acid concentrations were measured serially at baseline, 6 y, and 13 y. Deaths and CVD events were assessed and adjudicated centrally. Prospective associations were assessed by multivariate-adjusted Cox models incorporating time-dependent exposures and covariates. Results During 22 y of follow-up, 2428 deaths occurred, including 833 from CVD, 1595 from non-CVD causes, and 1301 incident CVD events. In multivariable models, circulating pentadecanoic, heptadecanoic, and trans-palmitoleic acids were not significantly associated with total mortality, with extreme-quintile HRs of 1.05 for pentadecanoic (95% CI: 0.91, 1.22), 1.07 for heptadecanoic (95% CI: 0.93, 1.23), and 1.05 for trans-palmitoleic (95% CI: 0.91, 1.20) acids. Circulating heptadecanoic acid was associated with lower CVD mortality (extreme-quintile HR: 0.77; 95% CI: 0.61, 0.98), especially stroke mortality, with a 42% lower risk when comparing extreme quintiles of heptadecanoic acid concentrations (HR: 0.58; 95% CI: 0.35, 0.97). In contrast, heptadecanoic acid was associated with a higher risk of non-CVD mortality (HR: 1.27; 95% CI: 1.07, 1.52), which was not clearly related to any single subtype of non-CVD death. No significant associations of pentadecanoic, heptadecanoic, or trans-palmitoleic acids were seen for total incident CVD, coronary heart disease, or stroke. Conclusions Long-term exposure to circulating phospholipid pentadecanoic, heptadecanoic, or trans-palmitoleic acids was not significantly associated with total mortality or incident CVD among older adults. High circulating heptadecanoic acid was inversely associated with CVD and stroke mortality and potentially associated with higher risk of non-CVD death.

The use of 123I-labeled heptadecanoic acid (HDA) as metabolic tracer: Preliminary report

1984 ◽  
Vol 9 (2) ◽  
Author(s):  
Robert Dudczak ◽  
Kurt Kletter ◽  
Hans Frischauf ◽  
Udo Losert ◽  
Peter Angelberger ◽  
...  
Keyword(s):  
Preliminary Report ◽  
Heptadecanoic Acid ◽  
Metabolic Tracer

scholarly journals Abnormal myocardial kinetics of 123 I-heptadecanoic acid in subjects with impaired glucose tolerance

Diabetologia ◽  
1997 ◽  
Vol 40 (5) ◽  
pp. 541-549 ◽  
Author(s):  
A. K. Turpeinen ◽  
J. T. Kuikka ◽  
E. Vanninen ◽  
M. I. J. Uusitupa
Keyword(s):  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Heptadecanoic Acid ◽  
Kinetics Of

Binary Langmuir Films Involving 1-Heptadecanoic Acid, 1-Hexadecanol, and 1-Heptadecanenitrile

1993 ◽  
Vol 156 (2) ◽  
pp. 438-445 ◽  
Author(s):  
Howard Williams ◽  
David A. Armitage ◽  
Roger G. Linford ◽  
Amélia M.P.S. Gonçalves Da Silva
Keyword(s):  
Langmuir Films ◽  
Heptadecanoic Acid

THE NORMAL C17 FATTY ACIDS OF MUSK-OX FAT

1957 ◽  
Vol 35 (12) ◽  
pp. 1434-1437 ◽  
Author(s):  
Mary J. Chisholm ◽  
C. Y. Hopkins
Keyword(s):  
Fatty Acids ◽  
Melting Point ◽  
Mixed Melting Point ◽  
Methyl Esters ◽  
Heptadecanoic Acid ◽  
X Ray Diffraction ◽  
Straight Chain ◽  
Trans Form ◽  
Total Fatty Acids ◽  
Musk Ox

A sample of body fat of the Canadian musk ox (Ovibosmoschatus subsp.) was converted to methyl esters and distilled. The fraction containing esters of C17 acids was crystallized fractionally at low temperature and two straight-chain C17 acids were isolated. n-Heptadecanoic acid was identified by analysis, by mixed melting point of the acid and two derivatives with authentic samples, and by its X-ray diffraction pattern. 9-Heptadecenoic acid was identified by analysis, by mixed melting point of two derivatives with authentic samples, and by oxidative cleavage. It is estimated that the fat contained 1.7% of n-heptadecanoic acid and 0.9% of cis-9-heptadecenoic acid, based on the total fatty acids. Although there was an appreciable content of trans acids in the fat, the heptadecenoic acid was found to contain little or none of the trans form.

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