scholarly journals Water-soluble Manganese and Iron Mesotetrakis(carboxyl)porphyrin: DNA Binding, Oxidative Cleavage, and Cytotoxic Activities

Molecules ◽  
2017 ◽  
Vol 22 (7) ◽  
pp. 1084 ◽  
Author(s):  
Lei Shi ◽  
Yi-Yu Jiang ◽  
Tao Jiang ◽  
Wei Yin ◽  
Jian-Ping Yang ◽  
...  
Keyword(s):  
Dna Binding ◽  
Oxidative Cleavage ◽  
Water Soluble ◽  
Cytotoxic Activities

DNA Binding and Oxidative Cleavage by a Water-soluble Carboxyl Manganese(III) Corrole

2013 ◽  
Vol 31 (10) ◽  
pp. 1321-1328 ◽  
Author(s):  
Yang Zhang ◽  
Qi Wang ◽  
Jinyan Wen ◽  
Xiangli Wang ◽  
Mian HR Mahmood ◽  
...  
Keyword(s):  
Dna Binding ◽  
Oxidative Cleavage ◽  
Water Soluble

DNA binding/cleavage, antioxidant and cytotoxic activities of water soluble cobalt(II) and copper(II) antipyrine complexes

2013 ◽  
Vol 406 ◽  
pp. 44-52 ◽  
Author(s):  
Subbaiyan Sathiyaraj ◽  
Krishnan Sampath ◽  
Gunasekaran Raja ◽  
Ray J. Butcher ◽  
Sushil K. Gupta ◽  
...  
Keyword(s):  
Dna Binding ◽  
Water Soluble ◽  
Cytotoxic Activities

Water soluble palladium(ii) and platinum(ii) acyclic diaminocarbene complexes: solution behavior, DNA binding, and antiproliferative activity

2020 ◽  
Vol 44 (15) ◽  
pp. 5762-5773 ◽  
Author(s):  
Tatiyana V. Serebryanskaya ◽  
Mikhail A. Kinzhalov ◽  
Vladimir Bakulev ◽  
Georgii Alekseev ◽  
Anastasiya Andreeva ◽  
...  
Keyword(s):  
Dna Binding ◽  
Antiproliferative Activity ◽  
Water Soluble ◽  
Solution Behavior ◽  
Antitumor Potential ◽  
Acyclic Diaminocarbene

Water soluble Pd(ii) and Pt(ii)–ADC species synthesized via the metal-mediated coupling of isocyanides and 1,2-diaminobenzene have demonstrated antitumor potential.

Water-soluble copper(II) complexes with 4,5-dichloro-isothiazole-3-carboxylic acid and heterocyclic N-donor ligands: Synthesis, crystal structures, cytotoxicity, and DNA binding study

2020 ◽  
Vol 510 ◽  
pp. 119778 ◽  
Author(s):  
Julia A. Eremina ◽  
Elizaveta V. Lider ◽  
Taisiya S. Sukhikh ◽  
Lyubov S. Klyushova ◽  
Maria L. Perepechaeva ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Dna Binding ◽  
Crystal Structures ◽  
Water Soluble ◽  
Binding Study ◽  
Donor Ligands

Acid–base properties and DNA-binding of water soluble N-confused porphyrins with cationic side-arms

2008 ◽  
Vol 6 (22) ◽  
pp. 4157 ◽  
Author(s):  
Yoshiya Ikawa ◽  
Shoji Moriyama ◽  
Hiroyuki Harada ◽  
Hiroyuki Furuta
Keyword(s):  
Dna Binding ◽  
Water Soluble ◽  
Acid Base ◽  
Base Properties

scholarly journals Ligatoxin B, a new cytotoxic protein with a novel helix–turn–helix DNA-binding domain from the mistletoe Phoradendron liga

2002 ◽  
Vol 366 (2) ◽  
pp. 405-413 ◽  
Author(s):  
Shi-Sheng LI ◽  
Joachim GULLBO ◽  
Petra LINDHOLM ◽  
Rolf LARSSON ◽  
Eva THUNBERG ◽  
...  
Keyword(s):  
Dna Binding ◽  
Cell Line ◽  
Binding Proteins ◽  
Molecular Mechanisms ◽  
Homology Modelling ◽  
Dna Binding Proteins ◽  
Dimensional Structure ◽  
Cytotoxic Activities ◽  
Cytotoxic Action ◽  
Working Hypothesis

A new basic protein, designated ligatoxin B, containing 46 amino acid residues has been isolated from the mistletoe Phoradendron liga (Gill.) Eichl. (Viscaceae). The protein's primary structure, determined unambiguously using a combination of automated Edman degradation, trypsin enzymic digestion, and tandem MS analysis, was 1–KSCCPSTTAR–NIYNTCRLTG–ASRSVCASLS–GCKIISGSTC–DSGWNH–46. Ligatoxin B exhibited in vitro cytotoxic activities on the human lymphoma cell line U-937-GTB and the primary multidrug-resistant renal adenocarcinoma cell line ACHN, with IC50 values of 1.8μM and 3.2μM respectively. Sequence alignment with other thionins identified a new member of the class 3 thionins, ligatoxin B, which is similar to the earlier described ligatoxin A. As predicted by the method of homology modelling, ligatoxin B shares a three-dimensional structure with the viscotoxins and purothionins and so may have the same mode of cytotoxic action. The novel similarities observed by structural comparison of the helix–turn–helix (HTH) motifs of the thionins, including ligatoxin B, and the HTH DNA-binding proteins, led us to propose the working hypothesis that thionins represent a new group of DNA-binding proteins. This working hypothesis could be useful in further dissecting the molecular mechanisms of thionin cytotoxicity and of thionin opposition to multidrug resistance, and useful in clarifying the physiological function of thionins in plants.

Sign in / Sign up

Export Citation Format

Share Document