scholarly journals On the Emerging Role of the Taste Receptor Type 1 (T1R) Family of Nutrient-Sensors in the Musculoskeletal System

Molecules ◽  
2017 ◽  
Vol 22 (3) ◽  
pp. 469 ◽  
Author(s):  
Shoichiro Kokabu ◽  
Jonathan Lowery ◽  
Takashi Toyono ◽  
Tsuyoshi Sato ◽  
Tetsuya Yoda
Keyword(s):  
Musculoskeletal System ◽  
Taste Receptor ◽  
Receptor Type

scholarly journals Longitudinal Expression of Testicular TAS1R3 from Prepuberty to Sexual Maturity in Congjiang Xiang Pigs

Animals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 437
Author(s):  
Ting Gong ◽  
Weiyong Wang ◽  
Houqiang Xu ◽  
Yi Yang ◽  
Xiang Chen ◽  
...  
Keyword(s):  
Sexual Maturity ◽  
Cell Function ◽  
Expression Patterns ◽  
Taste Receptor ◽  
Receptor Type ◽  
Mrna Levels ◽  
Early Puberty ◽  
Specific Expression

Testicular expression of taste receptor type 1 subunit 3 (T1R3), a sweet/umami taste receptor, has been implicated in spermatogenesis and steroidogenesis in mice. We explored the role of testicular T1R3 in porcine postnatal development using the Congjiang Xiang pig, a rare Chinese miniature pig breed. Based on testicular weights, morphology, and testosterone levels, four key developmental stages were identified in the pig at postnatal days 15–180 (prepuberty: 30 day; early puberty: 60 day; late puberty: 90 day; sexual maturity: 120 day). During development, testicular T1R3 exhibited stage-dependent and cell-specific expression patterns. In particular, T1R3 levels increased significantly from prepuberty to puberty (p < 0.05), and expression remained high until sexual maturity (p < 0.05), similar to results for phospholipase Cβ2 (PLCβ2). The strong expressions of T1R3/PLCβ2 were observed at the cytoplasm of elongating/elongated spermatids and Leydig cells. In the eight-stage cycle of the seminiferous epithelium in pigs, T1R3/PLCβ2 levels were higher in the spermatogenic epithelium at stages II–VI than at the other stages, and the strong expressions were detected in elongating/elongated spermatids and residual bodies. The message RNA (mRNA) levels of taste receptor type 1 subunit 1 (T1R1) in the testis showed a similar trend to levels of T1R3. These data indicate a possible role of T1R3 in the regulation of spermatid differentiation and Leydig cell function.

Dissecting the role of Corticotropin-releasing hormone receptor type 1 in Alzheimer's Disease

2011 ◽  
Vol 44 (06) ◽  
Author(s):  
K Lerche ◽  
M Willem ◽  
K Kleinknecht ◽  
C Romberg ◽  
U Konietzko ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Hormone Receptor ◽  
Receptor Type ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone

Protective role of vanilloid receptor type 1 in HCl‐induced gastric mucosal lesions in rats

2004 ◽  
Vol 39 (4) ◽  
pp. 303-312 ◽  
Author(s):  
S. Horie ◽  
H. Yamamoto ◽  
G. J. Michael ◽  
M. Uchida ◽  
A. Belai ◽  
...  
Keyword(s):  
Protective Role ◽  
Vanilloid Receptor ◽  
Receptor Type ◽  
Gastric Mucosal Lesions ◽  
Mucosal Lesions

Role of third intracellular loop of galanin receptor type 1 in signal transduction

Neuropeptides ◽  
2000 ◽  
Vol 34 (1) ◽  
pp. 25-31 ◽  
Author(s):  
K. Rezaei ◽  
K. Saar ◽  
U. Soomets ◽  
A. Valkna ◽  
J. Näsman ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Receptor Type ◽  
Intracellular Loop ◽  
Galanin Receptor ◽  
Third Intracellular Loop

scholarly journals Role of Cannabinoid Receptor Type 1 Desensitization in Greater Tetrahydrocannabinol Impairment of Memory in Adolescent Rats

2010 ◽  
Vol 335 (2) ◽  
pp. 294-301 ◽  
Author(s):  
Nicole L. T. Moore ◽  
Ashley L. R. Greenleaf ◽  
Shawn K. Acheson ◽  
Wilkie A. Wilson ◽  
H. Scott Swartzwelder ◽  
...  
Keyword(s):  
Cannabinoid Receptor ◽  
Receptor Type ◽  
Cannabinoid Receptor Type 1 ◽  
Adolescent Rats

scholarly journals Role of the Endothelium in the Vascular Effects of the Thrombin Receptor (Protease-Activated Receptor Type 1) in Humans

2008 ◽  
Vol 51 (18) ◽  
pp. 1749-1756 ◽  
Author(s):  
Ingibjörg J. Guðmundsdóttir ◽  
Ninian N. Lang ◽  
Nicholas A. Boon ◽  
Christopher A. Ludlam ◽  
David J. Webb ◽  
...  
Keyword(s):  
Receptor Type ◽  
Thrombin Receptor ◽  
Vascular Effects

Dual role of leukotriene B4 receptor type 1 in experimental sepsis

2015 ◽  
Vol 193 (2) ◽  
pp. 902-908 ◽  
Author(s):  
Xiu-juan Li ◽  
Hong-yu Fu ◽  
Wen-jing Yi ◽  
Yan-jun Zhao ◽  
Jun Wang ◽  
...  
Keyword(s):  
Leukotriene B4 ◽  
Dual Role ◽  
Receptor Type ◽  
Experimental Sepsis ◽  
Leukotriene B4 Receptor
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