scholarly journals Synthesis and Positive Inotropic Activity of [1,2,4]Triazolo[4,3-a] Quinoxaline Derivatives Bearing Substituted Benzylpiperazine and Benzoylpiperazine Moieties

Molecules ◽  
2017 ◽  
Vol 22 (2) ◽  
pp. 273
Author(s):  
Xue-Kun Liu ◽  
Long-Xu Ma ◽  
Zhi-Yu Wei ◽  
Xun Cui ◽  
Shi Zhan ◽  
...  
Keyword(s):  
Inotropic Activity ◽  
Quinoxaline Derivatives

PART I: NOVEL QUINOXALINE DERIVATIVES OF BIOLOGICAL INTEREST

2001 ◽  
Vol 24 (2) ◽  
pp. 135-144
Author(s):  
M. Badran ◽  
S. Botros ◽  
A. El-Gendy ◽  
N. Abdou ◽  
H. El-Assi ◽  
...  
Keyword(s):  
Biological Interest ◽  
Quinoxaline Derivatives ◽  
Derivatives Of

Design, Synthesis and Antimalarial Activity of Some New Aminoalcoholpyrrolo[1,2-a]quinoxaline Derivatives

2016 ◽  
Vol 13 (9) ◽  
pp. 932-942 ◽  
Author(s):  
Jean Guillon ◽  
Stéphane Moreau ◽  
Luisa Ronga ◽  
Louise Basmacyian ◽  
Anita Cohen ◽  
...  
Keyword(s):  
Antimalarial Activity ◽  
Design Synthesis ◽  
Quinoxaline Derivatives

New quinoxaline derivatives as VEGFR-2 inhibitors with anticancer and apoptotic activity: Design, molecular modeling, and synthesis

2021 ◽  
pp. 104807
Author(s):  
Nawaf A. Alsaif ◽  
Mohammed A. Dahab ◽  
Mohammed M. Alanazi ◽  
Ahmad J. Obiadullah ◽  
Abdulrahman A. Al-Mehizia ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Quinoxaline Derivatives ◽  
Apoptotic Activity ◽  
Activity Design

scholarly journals New Quinoxaline Derivatives as Dual Pim-1/2 Kinase Inhibitors: Design, Synthesis and Biological Evaluation

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 867
Author(s):  
Bruno Oyallon ◽  
Marie Brachet-Botineau ◽  
Cédric Logé ◽  
Thomas Robert ◽  
Stéphane Bach ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Cancer Progression ◽  
Kinase Inhibitors ◽  
Integration Site ◽  
Leukemia Virus ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Proviral Integration Site ◽  
Quinoxaline Derivatives

Proviral integration site for Moloney murine leukemia virus (Pim)-1/2 kinase overexpression has been identified in a variety of hematologic (e.g., multiple myeloma or acute myeloid leukemia (AML)) and solid (e.g., colorectal carcinoma) tumors, playing a key role in cancer progression, metastasis, and drug resistance, and is linked to poor prognosis. These kinases are thus considered interesting targets in oncology. We report herein the design, synthesis, structure–activity relationships (SAR) and in vitro evaluations of new quinoxaline derivatives, acting as dual Pim1/2 inhibitors. Two lead compounds (5c and 5e) were then identified, as potent submicromolar Pim-1 and Pim-2 inhibitors. These molecules were also able to inhibit the growth of the two human cell lines, MV4-11 (AML) and HCT-116 (colorectal carcinoma), expressing high endogenous levels of Pim-1/2 kinases.

Synthesis and vasorelaxant evaluation of novel 7-methoxyl-2,3-disubstituted-quinoxaline derivatives

2021 ◽  
Vol 36 ◽  
pp. 127785
Author(s):  
Chang-Bo Zheng ◽  
Wen-Cong Gao ◽  
Pan-Pan Pang ◽  
Xin Ma ◽  
Li-Chun Peng ◽  
...  
Keyword(s):  
Quinoxaline Derivatives

ChemInform Abstract: Preparation of Azulene Substituted Pyrazine and Quinoxaline Derivatives.

ChemInform ◽  
2009 ◽  
Vol 40 (27) ◽  
Author(s):  
Nozomi Furuta ◽  
Takuo Mizutani ◽  
Akira Ohta ◽  
Kunihide Fujimori
Keyword(s):  
Quinoxaline Derivatives

Synthesis and biological activities of pyrazolo[3,4-g]quinoxaline derivatives

2010 ◽  
Vol 45 (11) ◽  
pp. 5520-5526 ◽  
Author(s):  
Laurent Gavara ◽  
Emmanuelle Saugues ◽  
Georges Alves ◽  
Eric Debiton ◽  
Fabrice Anizon ◽  
...  
Keyword(s):  
Biological Activities ◽  
Quinoxaline Derivatives
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