scholarly journals Cytotoxic Compounds Derived from Marine Sponges. A Review (2010–2012)

Molecules ◽  
2017 ◽  
Vol 22 (2) ◽  
pp. 208 ◽  
Author(s):  
Roberto Mioso ◽  
Francisco Marante ◽  
Ranilson Bezerra ◽  
Flávio Borges ◽  
Bárbara Santos ◽  
...  
Keyword(s):  
Marine Sponges ◽  
Cytotoxic Compounds

Synthesis and Cytotoxicity Evaluation of Novel Indole Derivatives as Potential Anti-Cancer Agents

2019 ◽  
Vol 15 (8) ◽  
pp. 873-882
Author(s):  
Mona M. Kamel ◽  
Mohamed K. Abdel-hameid ◽  
Hala B. El-Nassan ◽  
Eman A. El-Khouly
Keyword(s):  
Cytotoxic Activity ◽  
Indole Alkaloids ◽  
Marine Sponges ◽  
Cytotoxic Agents ◽  
Wide Range ◽  
Anti Cancer ◽  
Effective Inhibition ◽  
Cytotoxic Compounds ◽  
Hct 116

Background: Marine sponges and tunicates have been a wealthy source of cytotoxic compounds such as indole alkaloids. Most of the indole alkaloids show in vitro cytotoxic and antineoplastic activities against a wide range of cancer cell lines. Objective: Three series of bioisosteres of marine indole alkaloids (meridianins) were synthesized and the compounds were tested for their in vitro anti-proliferative activity against HCT-116 cellline. In the design of the targeted analogues, the 2-aminopyrimidine ring of merdianins was replaced with 5-aminopyrazole, pyrazolo[1,5-a]pyrimidine and pyrazolo[3,4-b]pyridine rings. Results: The cytotoxic screening of the synthesized compounds revealed that pyrazolo[1,5- a]pyrimidines (compounds 9c and 11a) had the most potent cytotoxic activity with IC50 = 0.31 μM and 0.34 μM respectively. Compounds 9c and 11a were further investigated for their kinase inhibitory potencies toward six kinases (CDK5/p25, CK1ð/ε, GSK-3α/β, Dyrk1A, Erk2, and CLK1). They exhibited effective inhibition of GSK-3α/β (IC50 = 0.196 μM and 0.246 μM, respectively) and Erk2 (IC50 = 0.295 μM and 0.376 μM, respectively). Conclusion: Meridianins emerged as promising lead structures that need further development to obtain more selective and potent cytotoxic agents. One of these modifications involved the replacement of 2-aminopyrimidinyl ring of meridianins with other heterocyclic rings. Both pyrazolo[ 1,5-a]pyrimidine and pyrazolo[3,4-b]pyridine rings showed promising cytotoxic activity compared to the five membered 5-aminopyrazole.

scholarly journals Insights into Phosphatase-activated Chemical Defense in a Marine Sponge Holobiont

2021 ◽  
Author(s):  
Takahiro Jomori ◽  
Kenichi Matsuda ◽  
Yoko Egami ◽  
Ikuro Abe ◽  
Akira Takai ◽  
...  
Keyword(s):  
Chemical Defense ◽  
Marine Sponge ◽  
Marine Sponges ◽  
Cytotoxic Compounds ◽  
Discodermia Calyx

Marine sponges often contain potent cytotoxic compounds, which in turn evokes the principle question of how marine sponges avoid self-toxicity. In a marine sponge Discodermia calyx, the highly toxic calyculin...

A study on the cytotoxic activity of marine sponges on the embryo development of sea urchin Diadema savigny

2013 ◽  
pp. 107
Author(s):  
Esther D Angkouw ◽  
Remy E. P Mangindaan
Keyword(s):  
Ethyl Acetate ◽  
Cytotoxic Activity ◽  
Sea Urchin ◽  
High Probability ◽  
Ethanolic Extract ◽  
Marine Sponges ◽  
Cytotoxic Assay ◽  
Cytotoxic Compound ◽  
Axinella Corrugata ◽  
Cytotoxic Compounds

A study on the cytotoxic activity of five sponges has been conducted. The samples were collected from Malalayang beach, extraced with ethanol to give ethanolic extract. The ethanolic extratc then partitioned with hexane, ethyl acetate, buthanol to yield three fractions. Crude extracts, hexane and chloroform fractions were subjected to cytotoxic assay using fertilized Sea urchin eggs. The results showed that sponge Theonalla sp. contained a potential cytotoxic compound(s). After partitioned lay open that  dissolve fraction ethyl acetate showed activity of highest cytotoxic. The study gives a high probability in discovering many novel cytotoxic compounds from the sea© Suatu penelitian tentang pengujian aktivitas sitotoksik dari lima jenis spons (Petrosia nigricans, Plakinolophia mirabilis, Axinella corrugata, Ianthella basta, Theonella sp.) telah dilakukan. Spons yang diambil dari perairan Malalayang diekstrak dengan etanol. Ekstrak etanolik dipartisi dengan  pelarut heksan, etil asetat dan butanol. Ekstrak etanolik dan fraksi-fraksi diujikan pada sel telur bulu babi Diadema savigny yang telah dibuahi. Pengamatan dilakukan selama 48 jam. Hasil pengujian menunjukkan bahwa kontrol mencapai tahap pluteus sedangkan pengujian ekstrak etanolik dari kelima jenis spons diperoleh hasil Theonella sp. mempunyai aktivitas tertinggi. Sampel spons Theonella sp. mampu menghambat/memperlambat pembelahan sel bulu babi sampai pengamatan 48 jam hanya sampai pada pembelahan 4. Dari pengujian ketiga fraksi menunjukkan  bahwa fraksi etil asetat memiliki aktivitas sitotoksik yang tinggi dibanding fraksi heksan dan fraksi butanol. Hasil penelitian ini membuka peluang besar penemuan berbagai senyawa aktif sitotoksik dari organisme laut khususnya spons yang berasal dari perairan Sulawesi Utara©

scholarly journals Potensi antitumor dari beberapa spons laut asal teluk Manado

2017 ◽  
Vol 2 (2) ◽  
pp. 99
Author(s):  
Wilson Alexander Raymond Rombang
Keyword(s):  
Cell Activity ◽  
Leukemia Cell ◽  
Marine Sponges ◽  
Meoh Extract ◽  
Etoac Extract ◽  
Etoh Extract ◽  
Boring Sponge ◽  
Ic50 Value ◽  
Cytotoxic Compounds ◽  
Murine Leukemia Cell

Screening of antitumor for the extract and fraction from the marine sponges ofManado Gulf, Aaptos sp., Acervochalina sp., Gelliodes sp., Theonella sp., and orangeboring sponge have been done by use P388 murine leukemia cell. Activity test resultshowed IC50 of the extract and fraction from Aaptos sp were: MeOH extract 5938ng/mL and BuOH extract 125000 ng/mL; Acervochalina sp: EtOH extract 125000ng/mL, PE extract 125000 ng/mL, EtOAc extract 4251 ng/mL, BuOH extract125000 ng/mL; Gelliodes sp: EtOH extract 125000 ng/mL; Theonella sp: EtOHextract 125000 ng/mL, PE extract 9282 ng/mL, EtOAc extract 3273 ng/mL, BuOHextract 125000 ng/mL; orange boring sponge: MeOH extract 1422 ng/mL. Based onthe IC50 value, it could be concluded that MeOH extract of Aaptos sp., EtOAc extractof boring sponge could be a sources for cytotoxic compounds.

Ultrastructure of Giant Mitochondria and Their Inclusions in Schwann Cells of Bovine Splenic Nerve

1974 ◽  
Vol 32 ◽  
pp. 194-195
Author(s):  
Å. Thureson-Klein
Keyword(s):  
Schwann Cells ◽  
Cell Organelles ◽  
Giant Mitochondria ◽  
Matrix Density ◽  
Physiological Conditions ◽  
Unmyelinated Axons ◽  
Internal Structures ◽  
Structural Abnormalities ◽  
Cytotoxic Compounds ◽  
Cell Components

Giant mitochondria of various shapes and with different internal structures and matrix density have been observed in a great number of tissues including nerves. In most instances, the presence of giant mitochondria has been associated with a known disease or with abnormal physiological conditions such as anoxia or exposure to cytotoxic compounds. In these cases degenerative changes occurred in other cell organelles and, therefore the giant mitochondria also were believed to be induced structural abnormalities.Schwann cells ensheating unmyelinated axons of bovine splenic nerve regularly contain giant mitochondria in addition to the conventional smaller type (Fig. 1). These nerves come from healthy inspected animals presumed not to have been exposed to noxious agents. As there are no drastic changes in the small mitochondria and because other cell components also appear reasonably well preserved, it is believed that the giant mitochondria are normally present jin vivo and have not formed as a post-mortem artifact.

Ilimaquinone and minor metabolites from Polynesian marine sponges: Isolation and ecology

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
A Boufridi ◽  
C Debitus ◽  
A Maciuk ◽  
L Evanno ◽  
E Poupon
Keyword(s):  
Marine Sponges

Agelamadins, bromopyrrole alkaloids from Okinawan marine sponges Agelas spp.

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
N Tanaka ◽  
T Kusama ◽  
Y Kashiwada ◽  
J Kobayashi
Keyword(s):  
Marine Sponges

Production of Novel Bioactive Compounds by the Bacteria Associated with Some Marine Sponges of Gulf of Mannar and Palk Bay, Southeast Coast of India

2018 ◽  
Vol 6 (8) ◽  
pp. 183
Author(s):  
V. Ramadas ◽  
G. Chandralega
Keyword(s):  
Bioactive Compounds ◽  
Bacterial Species ◽  
Marine Sponges ◽  
Marine Organisms ◽  
Gulf Of Mannar ◽  
Bacterial Symbionts ◽  
Palk Bay ◽  
Excellent Source

Sponges, exclusively are aquatic and mostly marine, are found from the deepest oceans to the edge of the sea. There are approximately 15,000 species of sponges in the world, of which, 150 occur in freshwater, but only about 17 are of commercial value. A total of 486 species of sponges have been identified in India. In the Gulf of Mannar and Palk Bay a maximum of 319 species of sponges have been recorded. It has been proved that marine organisms are excellent source of bioactive secondary metabolites and number of compounds of originated from marine organisms had been reported to possess in-vitro and in-vivo immuno stimulatory activity. Extracts from 20 sponge species were tested for bacterial symbionts and bioactive compounds were isolated from such associated bacterial species in the present study.

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