scholarly journals Ligustrazine-Oleanolic Acid Glycine Derivative, G-TOA, Selectively Inhibited the Proliferation and Induced Apoptosis of Activated HSC-T6 Cells

Molecules ◽  
2016 ◽  
Vol 21 (11) ◽  
pp. 1599 ◽  
Author(s):  
Siling Bi ◽  
Fuhao Chu ◽  
Mina Wang ◽  
Bi Li ◽  
Pei Mao ◽  
...  
Keyword(s):  
Oleanolic Acid ◽  
Glycine Derivative ◽  
Induced Apoptosis

scholarly journals Caveolin-1 plays a key role in the oleanolic acid-induced apoptosis of HL-60 cells

2014 ◽  
Vol 32 (1) ◽  
pp. 293-301 ◽  
Author(s):  
WEI MA ◽  
DI-DI WANG ◽  
LI LI ◽  
YU-KUAN FENG ◽  
HONG-MEI GU ◽  
...  
Keyword(s):  
Oleanolic Acid ◽  
Caveolin 1 ◽  
Induced Apoptosis

scholarly journals Conjugation of Diclofenac with Novel Oleanolic Acid Derivatives Modulate Nrf2 and NF-κB Activity in Hepatic Cancer Cells and Normal Hepatocytes Leading to Enhancement of Its Therapeutic and Chemopreventive Potential

2021 ◽  
Vol 14 (7) ◽  
pp. 688
Author(s):  
Maria Narożna ◽  
Violetta Krajka-Kuźniak ◽  
Barbara Bednarczyk-Cwynar ◽  
Małgorzata Kucińska ◽  
Robert Kleszcz ◽  
...  
Keyword(s):  
Oleanolic Acid ◽  
Antioxidant Defense ◽  
Opposite Effect ◽  
Biological Evaluation ◽  
Benzyl Ester ◽  
Hepatic Cells ◽  
Anti Cancer ◽  
New Strategy ◽  
Induced Apoptosis ◽  
Synthesis And Biological Evaluation

Combining NSAIDs with conventional therapeutics was recently explored as a new strategy in cancer therapy. Our earlier studies showed that novel oleanolic acid oximes (OAO) conjugated with aspirin or indomethacin may enhance their anti-cancer potential through modulation of the Nrf2 and NF-κB signaling pathways. This study focused on the synthesis and biological evaluation of four diclofenac (DCL)–OAO derivative conjugates in the context of these pathways’ modification and hepatic cells survival. Treatment with the conjugates 4d, 3-diclofenacoxyiminoolean-12-en-28-oic acid morpholide, and 4c, 3-diclofenacoxyiminoolean-12-en-28-oic acid benzyl ester significantly reduced cell viability in comparison to the DCL alone. In THLE-2, immortalized normal hepatocytes treated with these conjugates resulted in the activation of Nrf2 and increased expression in SOD-1 and NQO1, while the opposite effect was observed in the HepG2 hepatoma cells. In both cell lines, reduced activation of the NF-κB and COX-2 expression was observed. In HepG2 cells, conjugates increased ROS production resulting from a reduced antioxidant defense, induced apoptosis, and inhibited cell proliferation. In addition, the OAO morpholide derivative and its DCL hybrid reduced the tumor volume in mice bearing xenografts. In conclusion, our study demonstrated that conjugating diclofenac with the OAO morpholide and a benzyl ester might enhance its anti-cancer activity in HCC.

ERK inhibition sensitizes cancer cells to oleanolic acid-induced apoptosis through ERK/Nrf2/ROS pathway

Tumor Biology ◽  
2015 ◽  
Vol 37 (6) ◽  
pp. 8181-8187 ◽  
Author(s):  
Jia Liu ◽  
Leina Ma ◽  
Xiao Chen ◽  
Jianxun Wang ◽  
Tao Yu ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Oleanolic Acid ◽  
Induced Apoptosis ◽  
Erk Inhibition

Absence of temporal ordering of apoptotic features in heat-shock treated leukemia and lymphoma cell lines

1996 ◽  
Vol 54 ◽  
pp. 758-759
Author(s):  
D. W. Fairbain ◽  
M.D. Standing ◽  
K.L. O'Neill
Keyword(s):  
Heat Shock ◽  
Cell Lines ◽  
Chromatin Condensation ◽  
Membrane Integrity ◽  
Resistant Cell ◽  
Membrane Blebbing ◽  
Late Loss ◽  
Induced Apoptosis ◽  
Dying Cells ◽  
In Cells

Apoptosis is a genetically defined response to physiological stimuli that results in cellular suicide. Features common to apoptotic cells include chromatin condensation, oligonucleosomal DNA fragmentation, membrane blebbing, nuclear destruction, and late loss of ability to exclude vital dyes. These characteristics contrast markedly from pathological necrosis, in which membrane integrity loss is demonstrated early, and other features of apoptosis, which allow a non-inflammatory removal of dead and dying cells, are absent. Using heat shock-induced apoptosis as a model for examining stress response in cells, we undertook to categorize a variety of human leukemias and lymphomas with regard to their response to heat shock. We were also interested in determining whether a common temporal order was followed in cells dying by apoptosis. In addition, based on our previous results, we investigated whether increasing heat load resulted in increased apoptosis, with particular interest in relatively resistant cell lines, or whether the mode of death changed from apoptosis to necrosis.

Gene array and knockout mouse analysis of VP-16 induced apoptosis in the murine small intestine

2001 ◽  
Vol 120 (5) ◽  
pp. A660-A660
Author(s):  
D MCMICHAEL ◽  
A DAVIES ◽  
E MARSHMAN ◽  
P OTTEWELL ◽  
J JENKINS ◽  
...  
Keyword(s):  
Small Intestine ◽  
Knockout Mouse ◽  
Gene Array ◽  
Murine Small Intestine ◽  
Induced Apoptosis

672: Regulation of Cavernous Nerve Injury-Induced Apoptosis by Sonic Hedgehog

2007 ◽  
Vol 177 (4S) ◽  
pp. 225-225
Author(s):  
Carol A. Podlasek ◽  
Yi Tang ◽  
Cynthia L. Meraz ◽  
Kevin E. McKenna ◽  
Kevin T. McVary
Keyword(s):  
Nerve Injury ◽  
Sonic Hedgehog ◽  
Cavernous Nerve ◽  
Induced Apoptosis ◽  
Cavernous Nerve Injury
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