scholarly journals One Pot Single Step Synthesis and Biological Evaluation of Some Novel Bis(1,3,4-thiadiazole) Derivatives as Potential Cytotoxic Agents

Molecules ◽  
2016 ◽  
Vol 21 (11) ◽  
pp. 1532 ◽  
Author(s):  
Sobhi Gomha ◽  
Nabila Kheder ◽  
Abdou Abdelhamid ◽  
Yahia Mabkhot
Keyword(s):  
Biological Evaluation ◽  
Single Step ◽  
Cytotoxic Agents ◽  
One Pot ◽  
Thiadiazole Derivatives ◽  
Synthesis And Biological Evaluation

Design, synthesis, and biological evaluation of new series of 2-amido-1,3,4-thiadiazole derivatives as cytotoxic agents

2016 ◽  
Vol 71 (3) ◽  
pp. 205-210 ◽  
Author(s):  
Ali Almasirad ◽  
Loghman Firoozpour ◽  
Maliheh Nejati ◽  
Najmeh Edraki ◽  
Omidreza Firuzi ◽  
...  
Keyword(s):  
Human Tumor ◽  
Inhibitory Effect ◽  
Biological Evaluation ◽  
Cytotoxic Agents ◽  
Antitumor Activities ◽  
Design Synthesis ◽  
Ethidium Bromide Staining ◽  
Thiadiazole Derivatives ◽  
Synthesis And Biological Evaluation

AbstractA series of novel 1,3,4-thiadiazole derivatives bearing an amide moiety were designed, synthesized, and evaluated for their in vitro antitumor activities against HL-60, SKOV-3 and MOLT-4 human tumor cell lines by MTT assay. Ethyl 2-((5-(4-methoxybenzamido)-1,3,4-thiadiazol-2-yl)thio)acetate (5f) showed the best inhibitory effect against SKOV-3 cells, with an IC50 value of 19.5 μm. In addition, the acridine orange/ethidium bromide staining assay in SKOV-3 cells suggested that the cytotoxic activity of 5f occurs via apoptosis.

scholarly journals Synthesis and Biological Evaluation of 1,2,4-Triazole and 1,3,4-Thiadiazole Derivatives as Potential Cytotoxic Agents

2013 ◽  
Vol 61 (11) ◽  
pp. 1099-1104 ◽  
Author(s):  
Yao-Jie Shi ◽  
Xue-Jiao Song ◽  
Xiao Li ◽  
Ting-Hong Ye ◽  
Ying Xiong ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Cytotoxic Agents ◽  
Thiadiazole Derivatives ◽  
Synthesis And Biological Evaluation

Synthesis and biological evaluation of 2-phenol-4-chlorophenyl-6-aryl pyridines as topoisomerase II inhibitors and cytotoxic agents

2016 ◽  
Vol 66 ◽  
pp. 145-159 ◽  
Author(s):  
Pritam Thapa ◽  
Tara Man Kadayat ◽  
Seojeong Park ◽  
Somin Shin ◽  
Til Bahadur Thapa Magar ◽  
...  
Keyword(s):  
Topoisomerase Ii ◽  
Biological Evaluation ◽  
Cytotoxic Agents ◽  
Topoisomerase Ii Inhibitors ◽  
Synthesis And Biological Evaluation

Green Synthesis and Biological Evaluation of New Di-α-aminophosphonate Derivatives as Cytotoxic Agents

2013 ◽  
Vol 346 (12) ◽  
pp. 851-859 ◽  
Author(s):  
Kunda Uma Maheswara Rao ◽  
Sim Namkoong ◽  
Hwan-Chul Yu ◽  
Junsoo Park ◽  
Chan-Moon Chung ◽  
...  
Keyword(s):  
Green Synthesis ◽  
Biological Evaluation ◽  
Cytotoxic Agents ◽  
Synthesis And Biological Evaluation
Sign in / Sign up

Export Citation Format

Share Document