scholarly journals Anti-Inflammatory Potential of Ethyl Acetate Fraction of Moringa oleifera in Downregulating the NF-κB Signaling Pathway in Lipopolysaccharide-Stimulated Macrophages

Molecules ◽  
2016 ◽  
Vol 21 (11) ◽  
pp. 1452 ◽  
Author(s):  
Palanisamy Arulselvan ◽  
Woan Tan ◽  
Sivapragasam Gothai ◽  
Katyakyini Muniandy ◽  
Sharida Fakurazi ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Signaling Pathway ◽  
Moringa Oleifera ◽  
Ethyl Acetate Fraction ◽  
Anti Inflammatory

scholarly journals Ethyl Acetate Fraction from Hedyotis diffusa plus Scutellaria barbata Exerts Anti-Inflammatory Effects by Regulating miR-155 Expression and JNK Signaling Pathway

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Yuan Xu ◽  
Xiao-Xia Chen ◽  
Yi-Xin Jiang ◽  
Dan-Dan Zhang
Keyword(s):  
Ethyl Acetate ◽  
Signaling Pathway ◽  
Ethyl Acetate Fraction ◽  
Equal Weight ◽  
Dependent Manner ◽  
Jnk Signaling ◽  
Scutellaria Barbata ◽  
Hedyotis Diffusa ◽  
Jnk Signaling Pathway ◽  
Anti Inflammatory

Hedyotis diffusa Willd and Scutellaria barbata D. Don (HDSB) were the core couplet in medicines that were commonly used for the purpose of anti-inflammation and anticancer treatments in China. However, biological properties of this couplet have not been fully elucidated. In this study, we screened fractions of HDSB for their anti-inflammatory activities and explored pertinent molecular mechanisms on murine macrophage RAW264.7 cell model. Ethyl acetate fraction from the aqueous extract of the couplet at equal weight ratio (EA11) showed the strongest inhibition of the nitrite accumulation in supernatant of RAW264.7 cells stimulated with lipopolysaccharide (LPS)/interferon-γ (IFN-γ). In addition, EA11 inhibited iNOS and IL-1β expression in a concentration-dependent manner while promoting the expression of HO-1 and PPAR-γ. Anti-inflammatory capability is most likely facilitated by its inhibitory effect on JNK signaling pathway and miR-155 expression. This study suggests that EA11 may be represented as a potential anti-inflammatory therapeutic candidate.

scholarly journals Anti-oxidant and Anti-inflammatory Activity of Ethyl Acetate Fraction of Moringa oleifera Flowers

2020 ◽  
pp. 1-8
Author(s):  
A. Rajeshkanna ◽  
M. M. Senthamilselvi ◽  
D. Prabhakaran
Keyword(s):  
Ethyl Acetate ◽  
Moringa Oleifera ◽  
Research Work ◽  
Ethyl Acetate Fraction ◽  
Inflammatory Activity ◽  
Dpph Assay ◽  
Membrane Stabilization ◽  
In Vivo Models ◽  
Anti Oxidant ◽  
Anti Inflammatory

Aims: To investigate the antioxidant and anti-inflammatory activities of ethyl acetate extract of  Moringa oleifera flowers. Place and Duration of Study: The research work was carried out at Research laboratory, Department of chemistry, Periyar E.V.R College, Trichy-23, between April 2017 and January 2018. Methodology: Extraction and fractionation were carried out from the solvents of ethanol, benzene, petroleum ether, diethyl ether and ethyl acetate.  The anti-inflammatory effect of the extract was investigated by HRBC membrane stabilization and Albumin denaturation methods. Anti-oxidant effect of the extract was determined by DPPH assay and ABTS method. Results: The dry sample extracted from the ethyl acetate fraction of Moringa oleifera flowers possess highly anti-oxidant activity showed by the DPPH assay and ABTS method and also having anti-inflammatory activity is determined by human red blood cell (HRBC) membrane stabilization and Albumin denaturation methods. However, these effects need to be confirmed using in vivo models and clinical trials before its utilization as a therapeutic agent. Conclusion: The present study was concluded that the dry sample of ethyl acetate fraction of Moringa oleifera flowers possesses effective anti-oxidant and anti-inflammatory activities.

Anti-inflammatory activity of ethyl acetate fraction of the seeds of Brucea Javanica

2013 ◽  
Vol 147 (2) ◽  
pp. 442-446 ◽  
Author(s):  
Jianhong Yang ◽  
Shucai Li ◽  
Caifeng Xie ◽  
Haoyu Ye ◽  
Huan Tang ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Ethyl Acetate Fraction ◽  
Inflammatory Activity ◽  
Brucea Javanica ◽  
Anti Inflammatory

scholarly journals The ethyl acetate fraction of Moringa oleifera leaves effects on endothelial stress in rat sepsis model

2019 ◽  
Vol 8 (3) ◽  
pp. 940
Author(s):  
Tatar Sumandjar ◽  
Bambang Purwanto ◽  
Brian Wasita ◽  
Dono Indarto ◽  
Risya Cilmiaty ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Moringa Oleifera ◽  
Ethyl Acetate Fraction ◽  
Sepsis Model ◽  
Moringa Oleifera Leaves ◽  
Endothelial Stress

Antinociceptive and anti-inflammatory activities of ethyl acetate fraction from Zanthoxylum armatum in mice

Fitoterapia ◽  
2011 ◽  
Vol 82 (3) ◽  
pp. 347-351 ◽  
Author(s):  
Tao Guo ◽  
Yun-Xia Deng ◽  
Hui Xie ◽  
Chun-Yan Yao ◽  
Cheng-Cheng Cai ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Ethyl Acetate Fraction ◽  
Zanthoxylum Armatum ◽  
Anti Inflammatory

Anti-Inflammatory and Antinociceptive Activity of Flavonoids Isolated from Viscum album ssp. album

2006 ◽  
Vol 61 (1-2) ◽  
pp. 26-30 ◽  
Author(s):  
Didem Deliorman Orhan ◽  
Esra Küpeli ◽  
Erdem Yesilada ◽  
Fatma Ergun
Keyword(s):  
Ethyl Acetate ◽  
Inflammatory Diseases ◽  
Ethyl Acetate Fraction ◽  
Viscum Album ◽  
Antinociceptive Activity ◽  
Paw Edema ◽  
Writhing Test ◽  
Activity Assessment ◽  
Edema Model ◽  
Anti Inflammatory

Abstract Viscum album L. has been used in the indigenous systems of medicine for treatment of headache and some inflammatory diseases. In order to evaluate this information, antinociceptive and anti-inflammatory activities of the five flavonoids (5,7-dimethoxy naringenin or 4′,6′- dimethoxy chalcononaringenin) derivatives, isolated from the ethyl acetate fraction of the extract from V. album ssp. album, were investigated, namely 5,7-dimethoxy-flavanone-4′-O- β-ᴅ-glucopyranoside (1), 2′-hydroxy-4′,6′-dimethoxy-chalcone-4-O-β-ᴅ-glucopyranoside (2), 5,7-dimethoxy-flavanone-4′-O-[2″-O-(5‴-O-trans-cinnamoyl)-β-ᴅ-apiofuranosyl]-β-ᴅ-glucopyranoside (3), 2′-hydroxy-4′,6′-dimethoxy-chalcone-4-O-[2″-O-(5‴-O-trans-cinnamoyl)-β-ᴅ-apiofuranosyl]- β-ᴅ-glucopyranoside (4), 5,7-dimethoxy-flavanone-4′-O-[β-d-apiofuranosyl- (152)]-β-ᴅ-glucopyranoside (5). For the antinociceptive activity assessment the p-benzoquinone- induced writhing test and for the anti-inflammatory activity the carrageenan-induced hind paw edema model in mice were used. The ethyl acetate fraction in a dose of 250 mg/kg as well as compounds 2 and 5 in a 30 mg/kg dose were shown to possess remarkable antinociceptive and anti-inflammatory activities per os without inducing any apparent acute toxicity as well as gastric damage

scholarly journals Chemical composition of Moringa oleifera ethyl acetate fraction and its biological activity in diabetic human dermal fibroblasts

2017 ◽  
Vol 13 (51) ◽  
pp. 462 ◽  
Author(s):  
Palanisamy Arulselvan ◽  
Sivapragasam Gothai ◽  
Katyakyini Muniandy ◽  
MazniAbu Zarin ◽  
TanWoan Sean ◽  
...  
Keyword(s):  
Biological Activity ◽  
Chemical Composition ◽  
Ethyl Acetate ◽  
Moringa Oleifera ◽  
Ethyl Acetate Fraction ◽  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts
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