scholarly journals Boronic Acid Group: A Cumbersome False Negative Case in the Process of Drug Design

Molecules ◽  
2016 ◽  
Vol 21 (9) ◽  
pp. 1185 ◽  
Author(s):  
Sotirios Katsamakas ◽  
Anastasios Papadopoulos ◽  
Dimitra Hadjipavlou-Litina
Keyword(s):  
Drug Design ◽  
Boronic Acid ◽  
False Negative ◽  
Acid Group ◽  
False Negative Case ◽  
Negative Case ◽  
Group A

Screening with the MEAMS: A false negative case study

1991 ◽  
Vol 6 (3) ◽  
pp. 202-203
Author(s):  
I. I. Lenzer ◽  
P. A. Street ◽  
S. Frausin-Murphy
Keyword(s):  
False Negative ◽  
False Negative Case ◽  
Negative Case

A False-Negative Case of Primary Central Nervous System Lymphoma on 11C-Methionine PET and Intense 18F-FDG Uptake

2016 ◽  
Vol 41 (8) ◽  
pp. 664-665 ◽  
Author(s):  
J.R. García-Garzon ◽  
Diego Villasboas-Rosciolesi ◽  
Miguel Baquero ◽  
Pere Bassa ◽  
Marina Soler ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
False Negative ◽  
Central Nervous System Lymphoma ◽  
Fdg Uptake ◽  
False Negative Case ◽  
Negative Case ◽  
18F Fdg

Equivalent cross relaxation rate image for decreasing a false negative case of sentinel lymph node biopsy

2003 ◽  
Vol 21 (9) ◽  
pp. 1045-1047 ◽  
Author(s):  
Shigeru Matsushima ◽  
Fumio Sasaki ◽  
Shuhei Sarumaru ◽  
Daisuke Ohta ◽  
Seiichi Era ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Relaxation Rate ◽  
False Negative ◽  
Lymph Node Biopsy ◽  
Cross Relaxation ◽  
Node Biopsy ◽  
False Negative Case ◽  
Negative Case

Identification of Streptococcus pyogenes in a Pediatric Outpatient Department: A Practical System Designed for Rapid Results and Resident Teaching

PEDIATRICS ◽  
1974 ◽  
Vol 54 (6) ◽  
pp. 718-723
Author(s):  
Katherine Sprunt ◽  
Dorothea Vail ◽  
Russell S. Asnes
Keyword(s):  
False Positive ◽  
Fluorescent Antibody ◽  
False Negative ◽  
Screening Method ◽  
Rapid Screening ◽  
Resident Teaching ◽  
Antibody Uptake ◽  
Busy Clinic ◽  
Group A ◽  
Laboratory Tool

A rapid screening method for identification of clinic patients with pharyngitis who are carrying group A beta-hemolytic streptococci and for teaching residents the values and limitations of the culture-disk approach to identification has been reviewed as developed for a busy clinic and a busy hospital laboratory. Identification of positive cultures in less than 24 hours, using Taxos A disk and specific fluorescent antibody uptake, resulted in 12% apparent false-positive and 3.6% false-negative reports. However, when viewed in the light of the techniques used for verifying results, there were probably 3% false-positive and 3% false-negative reports. The screening method is considered acceptably reliable and practical as a laboratory tool and a resident teaching device.

scholarly journals P077 Reliability of the Clinical Characterization of Isolated REM Sleep Behavior Disorder

2021 ◽  
Vol 2 (Supplement_1) ◽  
pp. A46-A46
Author(s):  
D Levendowski ◽  
J Lee-Iannotti ◽  
D Shprecher ◽  
C Guevarra ◽  
P Timm ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Rem Sleep ◽  
False Positive ◽  
False Negative ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Sleep Behavior ◽  
Negative Case ◽  
Rem Sleep Without Atonia

Abstract Purpose Compare agreements between polysomnography-based (PSG) diagnosis of isolated REM-sleep-behavior-disorder (iRBD) and Non-REM-Hypertonia (NRH), a novel biomarker independently associated with synucleinopathy-related neurodegenerative diseases. Methods Sixteen patients with histories of dream-enactment-behavior (DEB)(women=38%; age:64.6±13.0) underwent PSG with simultaneously-recorded Sleep Profiler (SP). Two boarded sleep neurologists independently characterized iRBD. Physician1 combined abnormal qualitative REM-sleep-without-atonia (RSWA) by submental electromyography, with video-confirmation of probably DEB. Physician2 relied solely on qualitative RSWA. SP was auto-staged, technically reviewed, and reprocessed for automated abnormal NRH detection. Kappa scores measured physician and NRH agreements. Results In the 14 records with REM sleep, iRBD was characterized in: Physician1=64%, Physician2=79%, NRH=71% of the records. Across the three methods, unanimous iRBD agreement occurred in 57% of the records (positive=7, negative=1). The between-physician agreement in iRBD classifications was fair (kappa=0.32). The agreement between NRH and Physician1 was moderate (kappa=0.52) versus slight with Physician2 (kappa=0.05). NRH comparisons to consensus physician agreement yielded one false-positive and one false-negative iRBD finding. Physician2 classified: a) iRBD in two cases that were negative by Physician1 and NRH, and b) one negative case that Physician1 and NRH characterized as iRBD. Physician1 identified one negative case that was classified iRBD by Physician2 and NRH. Additionally, NRH was abnormal in one of the two records with no REM sleep. Discussion NRH may assist in iRBD risk assessment, given it agreed with at least one physician in 86% of the cases and the between-physician iRBD agreement was only fair. NRH also characterized iRBD-risk in patients with insufficient REM sleep for RSWA assessment.

Gallium scans in the evaluation of residual masses after chemotherapy for seminoma.

1995 ◽  
Vol 13 (11) ◽  
pp. 2784-2788 ◽  
Author(s):  
G P Warren ◽  
L H Einhorn
Keyword(s):  
False Negative ◽  
Fibrous Tissue ◽  
Salvage Chemotherapy ◽  
First Line ◽  
Chemotherapy Group ◽  
Computed Tomographic ◽  
Group A ◽  
Residual Masses ◽  
Group B

PURPOSE To assess the ability of gallium scans to determine whether residual masses consist of viable tumor or necrotic fibrous tissue after chemotherapy for seminoma. PATIENTS AND METHODS Thirty-two patients were enrolled and 27 were assessable. Patients receiving first-line or salvage chemotherapy had gallium scans performed during their first and last scheduled course of chemotherapy and results were compared with restaging computed tomographic (CT) scans and subsequent clinical outcome. RESULTS Of 27 assessable patients, 22 received first-line chemotherapy (group A) and five salvage chemotherapy (group B). Eight patients were not gallium-avid before chemotherapy despite obvious clinical and radiographic evidence of metastatic seminoma. Eighteen of 19 gallium-positive patients had a persistent mass postchemotherapy on abdominal CT. Of 16 patients in group A whose tumors were gallium-avid, all 16 had normalized gallium scans after chemotherapy. However, two of these 16 patients recurred in their original disease site. In group B, there were three patients with gallium-avid tumors and all three had normalized scans postchemotherapy. Two patients who were not gallium-avid (one each in group A and B) also developed recurrent disease. Twenty-four of 27 patients are alive with no evidence of active disease at a median follow-up time of 18 months, including 20 with more than 1 year of follow-up data. CONCLUSION Eight of 27 patients had false-negative gallium scans at the time of diagnosis. All nineteen gallium scans that were initially positive reverted to normal after chemotherapy. Two of 19 patients' follow-up gallium scans were false-negative. We therefore feel that gallium scans have minimal value in the prechemotherapy or postchemotherapy evaluation of metastatic seminoma.

scholarly journals Pulse Oximetry and Congenital Heart Disease Screening: Results of the First Pilot Study in Morocco

2020 ◽  
Vol 6 (3) ◽  
pp. 53
Author(s):  
Nadia El Idrissi Slitine ◽  
Fatiha Bennaoui ◽  
Craig A. Sable ◽  
Gerard R. Martin ◽  
Lisa A. Hom ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Pilot Study ◽  
Pulse Oximetry ◽  
Screening Test ◽  
Congenital Heart ◽  
False Negative ◽  
University Hospital ◽  
Critical Congenital Heart Disease ◽  
Negative Case

Congenital heart disease (CHD) is the most common congenital malformation. Diagnosis of critical congenital heart disease (CCHD), the most severe type of congenital heart disease, in a newborn may be difficult. The addition of CCHD screening, using pulse oximetry, to clinical assessment significantly improves the rate of detection. We conducted a pilot study in Morocco on screening neonates for critical congenital heart disease. This study was conducted in the maternity ward of Mohammed VI University Hospital of Marrakesh, Morocco, and included asymptomatic newborns delivered between March 2019 and January 2020. The screening of CCHD was performed by pulse oximetry measuring the pre- and post-ductal saturation. Screening was performed on 8013/10,451 (76.7%) asymptomatic newborns. According to the algorithm, 7998 cases passed the screening test (99.82%), including one inconclusive test that was repeated an hour later and was normal. Fifteen newborns failed the screening test (0.18%): five CCHD, five false positives, and five CHD but non-critical. One false negative case was diagnosed at 2 months of age. Our results encourage us to strengthen screening for CCHD by adding pulse oximetry to the routine newborn screening panel.

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