scholarly journals Qingxuan Jiangya Decoction Reverses Vascular Remodeling by Inducing Vascular Smooth Muscle Cell Apoptosis in Spontaneously Hypertensive Rats

Molecules ◽  
2016 ◽  
Vol 21 (7) ◽  
pp. 956 ◽  
Author(s):  
Fei Xiao ◽  
Fei He ◽  
Hongwei Chen ◽  
Shan Lin ◽  
Aling Shen ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Cell Apoptosis ◽  
Vascular Remodeling ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Muscle Cell Apoptosis

Isoflurane Alters Angiotensin II–Induced Ca2+Mobilization in Aortic Smooth Muscle Cells from Hypertensive Rats

2002 ◽  
Vol 97 (3) ◽  
pp. 642-651 ◽  
Author(s):  
Emmanuel Samain ◽  
Hélène Bouillier ◽  
Catherine Rucker-Martin ◽  
Jean-Xavier Mazoit ◽  
Jean Marty ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Intracellular Ca ◽  
Wistar Kyoto

Background Angiotensin II (AngII) is a potent vasoconstrictor involved in the short-term control of arterial blood pressure. Isoflurane was reported to decrease vascular tone through an alteration of vascular smooth muscle cell vasomotor response to several agonists, but its effect on AngII signaling is not known. On the other hand, vascular response to AngII is altered in hypertension. In this study, the authors tested the hypothesis that (1) isoflurane alters AngII-induced intracellular Ca mobilization in aortic vascular smooth muscle cell from Wistar Kyoto and spontaneously hypertensive rats, and (2) this effect could be associated with an alteration of the organization of microtubular network, reported to be involved in AngII signaling. Methods The effect of 0.5-3% isoflurane was studied (1) on AngII (10 m)-induced intracellular Ca mobilization, intracellular Ca release from internal stores, and Ca influx in Fura-2 loaded cultured aortic vascular smooth muscle cell isolated from 6-week-old Wistar Kyoto and spontaneously hypertensive rats, using fluorescent imaging microscopy; and (2) on the organization of cytoskeletal elements, using immunofluorescence labeling. Results In both stains, isoflurane decreased in a concentration-dependent manner AngII-induced intracellular Ca mobilization, Ca release from internal stores, and Ca influx through nifedipine-insensitive Ca channels. This effect occurred at a lower concentrations of isoflurane in Wistar Kyoto rats than in spontaneously hypertensive rats. In both strains, the effect of isoflurane on AngII- Ca mobilization was abolished by impairment with nocodazole, vinblastine, or paclitaxel of microtubules polymerization. Isoflurane directly altered tubular network organization in a concentration-dependent and reversible manner. Conclusions Isoflurane decreased AngII-induced Ca mobilization at clinically relevant concentrations, suggesting that vascular response to AngII could be altered during isoflurane anesthesia. The hypertensive strain was found less sensitive than the normotensive one. In both strains, the isoflurane effect was associated with a microtubular network interaction.

scholarly journals Marginal dietary zinc deficiency in vivo induces vascular smooth muscle cell apoptosis in large arteries

2013 ◽  
Vol 99 (3) ◽  
pp. 525-534 ◽  
Author(s):  
Keith Allen-Redpath ◽  
Ou Ou ◽  
John H. Beattie ◽  
In-Sook Kwun ◽  
Jorg Feldmann ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Zinc Deficiency ◽  
Vascular Smooth Muscle Cell ◽  
Cell Apoptosis ◽  
Large Arteries ◽  
Muscle Cell Apoptosis

scholarly journals Vascular smooth muscle cell apoptosis in aneurysmal, occlusive, and normal human aortas

2000 ◽  
Vol 31 (3) ◽  
pp. 567-576 ◽  
Author(s):  
Vincent L. Rowe ◽  
Scott L. Stevens ◽  
Tonya T. Reddick ◽  
Michael B. Freeman ◽  
Robert Donnell ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Cell Apoptosis ◽  
Normal Human ◽  
Muscle Cell Apoptosis
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