scholarly journals The Tissue Distribution and Urinary Excretion Study of Gallic Acid and Protocatechuic Acid after Oral Administration of Polygonum Capitatum Extract in Rats

Molecules ◽  
2016 ◽  
Vol 21 (4) ◽  
pp. 399 ◽  
Author(s):  
Feng-Wei Ma ◽  
Qing-Fang Deng ◽  
Xin Zhou ◽  
Xiao-Jian Gong ◽  
Yang Zhao ◽  
...  
Keyword(s):  
Oral Administration ◽  
Urinary Excretion ◽  
Tissue Distribution ◽  
Gallic Acid ◽  
Protocatechuic Acid ◽  
Excretion Study

scholarly journals Metabolic studies of [75Se]selenomethionine and [75Se]selenite in the rat

1973 ◽  
Vol 30 (1) ◽  
pp. 139-147 ◽  
Author(s):  
Christine D. Thomson ◽  
R. D. H. Stewart
Keyword(s):  
Oral Administration ◽  
Urinary Excretion ◽  
Tissue Distribution ◽  
Intestinal Absorption ◽  
Initial Period ◽  
Similar Rate ◽  
Whole Body ◽  
Body Retention ◽  
Metabolic Pool

1. Information was sought concerning the long-term fate of orally and intravenously administered [75Se]selenomethionine and [75Se]selenite in rats.2. Urinary and faecal radioactivity was assayed during the 1st week and whole-body radio-activity was determined weekly for 16 weeks. Rats were killed at intervals for analysis of 75Se tissue distribution.3. Intestinal absorption after oral administration was estimated to be 91–93% for selenite and 95–97% for selenomethionine.4. Urinary excretion of absorbed [75Se]selenite was greater than that of [75Se]selenomethionine during the 1st week.5. After the 1st week, whole-body retention diminished exponentially at a similar rate in rats given either selenomethionine or selenite. Except for the erythrocytes, 75Se content of individual tissues also decreased exponentially.6. It appears that, after an initial period, 75Se from either selenomethionine or selenite is metabolized similarly, suggesting that Se from both potential dietary sources is ultimately incorporated into the same metabolic pool.

Application of an LC-MS/MS Method to a Urinary Excretion Study of Triflusal and its Main Metabolite 2-hydroxy-4-trifluoromethyl Benzoic Acid in Human Urine

2020 ◽  
Vol 16 (3) ◽  
pp. 328-334
Author(s):  
Jie Ge ◽  
Jin-Wen Wang ◽  
Qi-Yan Guo ◽  
Ai-Dong Wen
Keyword(s):  
Benzoic Acid ◽  
Urinary Excretion ◽  
Human Urine ◽  
Multiple Reaction Monitoring ◽  
Main Metabolite ◽  
Linear Relationships ◽  
Pharmacokinetic Properties ◽  
Liquid Chromatography Tandem Mass ◽  
Excretion Study ◽  
Acetate Aqueous Solution

Objective: A validated liquid chromatography-tandem mass spectrometry method (LCMS/ MS) was established to simultaneously determine the concentration of triflusal and its main metabolite 2-hydroxy-4-trifluoromethyl benzoic acid(HTB) in human urine. Methods: The separation was performed on a Dikma C18 column using isocratic elution with acetonitrile-4 mmol/L ammonium acetate aqueous solution containing 0.3 % formic acid water (78: 28, V/V). The method involved extraction with methanol using protein precipitation. The precursor-toproduct ion transitions with multiple reaction monitoring was m/z 247.1→161.1, 204.8→106.7and 136.9→93.0 for triflusal, HTB and salicylic acid(IS), respectively. The method showed good linear relationships over the ranges of 0.08 to 48 μg/mL and0.5 to 50 μg/mL. Results: It was the first time that a urinary excretion study of triflusal capsule as oral. The cumulative urinary recovery showed 8.5% and 2.7% for triflusal and HTB, respectively. Conclusion: This method was successfully used for evaluating the pharmacokinetic properties of triflusal and HTB in urine in Chinese healthy subjects.

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