scholarly journals Phenolics from Garcinia mangostana Inhibit Advanced Glycation Endproducts Formation: Effect on Amadori Products, Cross-Linked Structures and Protein Thiols

Molecules ◽  
2016 ◽  
Vol 21 (2) ◽  
pp. 251 ◽  
Author(s):  
Hossam Abdallah ◽  
Hany El-Bassossy ◽  
Gamal Mohamed ◽  
Ali El-Halawany ◽  
Khalid Alshali ◽  
...  
Keyword(s):  
Advanced Glycation Endproducts ◽  
Advanced Glycation ◽  
Garcinia Mangostana ◽  
Amadori Products ◽  
Glycation Endproducts ◽  
Protein Thiols

scholarly journals Non-enzymatic glycation of proteins: from diabetes to cancer

2010 ◽  
Vol 56 (2) ◽  
pp. 168-178 ◽  
Author(s):  
N.A. Ansari ◽  
Z. Rasheed
Keyword(s):  
Current Knowledge ◽  
Advanced Glycation Endproducts ◽  
Diabetic Patients ◽  
Advanced Glycation ◽  
Diagnostic Biomarkers ◽  
Amadori Products ◽  
Glycation Endproducts ◽  
Glycation Product ◽  
Major Route

Incubation of proteins with glucose leads to their non-enzymatic glycation and formation of Amadori products known as an early glycation product. Oxidative cleavage of Amadori products is considered as a major route to advanced glycation endproducts (AGEs) formation in vivo. Nonenzymatic glycation of proteins or Maillard reaction is increased in diabetes mellitus due to hyperglycemia and leads to several complications such as blindness, heart disease, nerve damage and kidney failure. Accumulation of the early and advanced glycation products in plasma and tissues of diabetic patients and causes production of autoantibodies against corresponding products. The advanced glycation products are also associated with other diseases like cancer. This review summarizes current knowledge of these stage specific glycated products as common and early diagnostic biomarkers for the associated diseases and the complications with the aim of a novel therapeutic target for the diseases.

scholarly journals The Immune Tolerance Role of the HMGB1-RAGE Axis

Cells ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 564
Author(s):  
Haruki Watanabe ◽  
Myoungsun Son
Keyword(s):  
Immune Responses ◽  
Immune Tolerance ◽  
Lupus Erythematosus ◽  
Advanced Glycation Endproducts ◽  
High Mobility ◽  
Chromatin Binding ◽  
Advanced Glycation ◽  
Glycation Endproducts ◽  
Extracellular Milieu

The disruption of the immune tolerance induces autoimmunity such as systemic lupus erythematosus and vasculitis. A chromatin-binding non-histone protein, high mobility group box 1 (HMGB1), is released from the nucleus to the extracellular milieu in particular environments such as autoimmunity, sepsis and hypoxia. Extracellular HMGB1 engages pattern recognition receptors, including Toll-like receptors (TLRs) and the receptor for advanced glycation endproducts (RAGE). While the HMGB1-RAGE axis drives inflammation in various diseases, recent studies also focus on the anti-inflammatory effects of HMGB1 and RAGE. This review discusses current perspectives on HMGB1 and RAGE’s roles in controlling inflammation and immune tolerance. We also suggest how RAGE heterodimers responding microenvironments functions in immune responses.

scholarly journals Is skin autofluorescence (SAF) representative of dermal advanced glycation endproducts (AGEs) in dark skin? A pilot study

Heliyon ◽  
2020 ◽  
Vol 6 (11) ◽  
pp. e05364
Author(s):  
Isabella M. Atzeni ◽  
Jeltje Boersema ◽  
Hendri H. Pas ◽  
Gilles F.H. Diercks ◽  
Jean L.J.M. Scheijen ◽  
...  
Keyword(s):  
Pilot Study ◽  
Advanced Glycation Endproducts ◽  
Skin Autofluorescence ◽  
Advanced Glycation ◽  
Dark Skin ◽  
Glycation Endproducts

scholarly journals Receptor for advanced glycation endproducts (RAGE) maintains pulmonary structure and regulates the response to cigarette smoke

PLoS ONE ◽  
2017 ◽  
Vol 12 (7) ◽  
pp. e0180092 ◽  
Author(s):  
Lisa Wolf ◽  
Christian Herr ◽  
Julia Niederstraßer ◽  
Christoph Beisswenger ◽  
Robert Bals
Keyword(s):  
Cigarette Smoke ◽  
Advanced Glycation Endproducts ◽  
Advanced Glycation ◽  
Glycation Endproducts
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