scholarly journals Synthesis and Characterization of Some New Coumarins with in Vitro Antitumor and Antioxidant Activity and High Protective Effects against DNA Damage

Molecules ◽  
2016 ◽  
Vol 21 (2) ◽  
pp. 249 ◽  
Author(s):  
Mounir Salem ◽  
Magda Marzouk ◽  
Azza El-Kazak
Keyword(s):  
Dna Damage ◽  
Antioxidant Activity ◽  
Synthesis And Characterization ◽  
Protective Effects

scholarly journals Synthesis and Characterization of Inulin Butyrate Ester, and Evaluation of Its Antioxidant Activity and In Vitro Effect on SCFA Production

2020 ◽  
Vol 72 (11-12) ◽  
pp. 1900323
Author(s):  
Xiaozhen Zhu ◽  
Xia Zhang ◽  
Xuelu Gao ◽  
Xianyao Meng ◽  
Yuetao Yi
Keyword(s):  
Antioxidant Activity ◽  
Synthesis And Characterization ◽  
Vitro Effect

scholarly journals Synthesis and Characterization of High Molecular Weight Chitosan, and Antioxidant Activity of Its Chitosan Oligosaccharide Encapsulation

2021 ◽  
Vol 42 (1) ◽  
pp. 29-38
Author(s):  
Hari Sharan Adhikari ◽  
Aditya Garai ◽  
Bishnu Prasad Marasini ◽  
Rameshwar Adhikari ◽  
Paras Nath Yadav
Keyword(s):  
Molecular Weight ◽  
Antioxidant Activity ◽  
High Molecular Weight ◽  
Synthesis And Characterization ◽  
Target Cells ◽  
Chitosan Oligosaccharide ◽  
High Molecular Weight Chitosan ◽  
In Vitro Antioxidant Activity

High molecular weight nanocrystalline chitosan (HMWNC)with Mw of 350 kDa and 66.92% DDA was prepared by alkaline N-deacetylation of chitin that was abundantly obtained after demineralization and deproteinization of pulverized crab shells, and commercially available chitosan oligosaccharide (COS) with average Mw< 3000 Da and 87% DDA was encapsulated with HMWNC. The encapsulation of COS as a pharmaceutical ingredient into HMWC was hypothesized to enhance the bioavailability of COS in target cells. The HMWNC encapsulated chitosan oligosaccharide (COS-HMWNC) showed in vitro antioxidant activity on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals (IC50 = 512.6±14.4 μg/mL) while others showed less than 50% inhibition at 1000 μg/mL. The lower the molecular weight of chitosan, the higher was the antioxidant activity. The study showed that the encapsulation of COS molecules in HMWNCcould be used as a simple and effective way of enhancing the antioxidant activity of COS.

Antioxidant Activity, Phenolic Content and Hematoprotective Effects of Cleome arabica Polyphenolic Leaf Extract

2019 ◽  
Author(s):  
C. Tigrine ◽  
A. Kameli
Keyword(s):  
Antioxidant Activity ◽  
Biological Effects ◽  
Reducing Power ◽  
Hematological Toxicity ◽  
Protective Effects ◽  
Ferrous Ions ◽  
Polyphenolic Extract ◽  
Cleome Arabica

In this study a polyphenolic extract from Cleome arabica leaves (CALE) was investigated for its antioxidant activity in vitro using DPPH•, metal chelating and reducing power methods and for its protective effects against AraC-induced hematological toxicity in vivo using Balb C mice. Results indicated that CALE exhibited a strong and dose-dependent scavenging activity against the DPPH• free radical (IC50 = 4.88 μg/ml) and a high reducing power activity (EC50 = 4.85 μg/ml). Furthermore, it showed a good chelating effects against ferrous ions (IC50 = 377.75 μg/ml). The analysis of blood showed that subcutaneous injection of AraC (50 mg/kg) to mice during three consecutive days caused a significant myelosupression (P < 0.05). The combination of CALE and AraC protected blood cells from a veritable toxicity. Where, the number of the red cells, the amount of hemoglobin and the percentage of the hematocrite were significantly high. On the other hand, AraC cause an elevation of body temperature (39 °C) in mice. However, the temperature of the group treated with CALE and AraC remained normal and did not exceed 37.5 °C. The observed biological effects of CALE, in vitro as well as in vivo, could be due to the high polyphenol and flavonoid contents. In addition, the antioxidant activity of CALE suggested to be responsible for its hematoprotective effect.

scholarly journals Synthesis and Characterization of Novel Cu(II), Pd(II) and Pt(II) Complexes with 8-Ethyl-2-hydroxytricyclo(7.3.1.02,7)tridecan-13-one-thiosemicarbazone: Antimicrobial and in Vitro Antiproliferative Activity

Molecules ◽  
2016 ◽  
Vol 21 (5) ◽  
pp. 674 ◽  
Author(s):  
Elena Pahonțu ◽  
Codruța Paraschivescu ◽  
Diana-Carolina Ilieș ◽  
Donald Poirier ◽  
Camelia Oprean ◽  
...  
Keyword(s):  
Antiproliferative Activity ◽  
Synthesis And Characterization
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