scholarly journals In Vivo and In Vitro Toxicity Evaluation of Polyprenols Extracted from Ginkgo biloba L. Leaves

Molecules ◽  
2015 ◽  
Vol 20 (12) ◽  
pp. 22257-22271 ◽  
Author(s):  
Cheng-Zhang Wang ◽  
Jiao-Jiao Yuan ◽  
Wen-Jun Li ◽  
Hong-Yu Zhang ◽  
Jian-Zhong Ye
Keyword(s):  
Ginkgo Biloba ◽  
In Vitro Toxicity ◽  
Toxicity Evaluation

In vitro toxicity evaluation of ultra-small MFe2O4 (M = Fe, Mn, Co) nanoparticles using A549 cells

RSC Advances ◽  
2015 ◽  
Vol 5 (84) ◽  
pp. 68454-68460 ◽  
Author(s):  
Hongli Zhao ◽  
Zongyan Chen ◽  
Liang Tao ◽  
Xiang Zhu ◽  
Minbo Lan ◽  
...  
Keyword(s):  
A549 Cells ◽  
Safety Evaluation ◽  
Ferrite Nanoparticles ◽  
In Vitro Toxicity ◽  
Toxicity Evaluation ◽  
Biomedical Field ◽  
Co Nanoparticles

As ferrite nanoparticles (MFe2O4) have been widely used in biomedical field, their safety evaluation has been paid great attention both in vitro and in vivo.

Drug solubilization and in vitro toxicity evaluation of lipoamino acid surfactants

2012 ◽  
Vol 423 (2) ◽  
pp. 312-320 ◽  
Author(s):  
Nathalie Ménard ◽  
Nicolas Tsapis ◽  
Cécile Poirier ◽  
Thomas Arnauld ◽  
Laurence Moine ◽  
...  
Keyword(s):  
In Vitro Toxicity ◽  
Toxicity Evaluation ◽  
Lipoamino Acid ◽  
Drug Solubilization

Integration of in vitro neurotoxicity data with biokinetic modelling for the estimation of in vivo neurotoxicity

2007 ◽  
Vol 26 (4) ◽  
pp. 333-338 ◽  
Author(s):  
Anna Forsby ◽  
Bas Blaauboer
Keyword(s):  
Exposure Period ◽  
Cellular Protein ◽  
In Vitro Toxicity ◽  
Target Tissue ◽  
Receptor Function ◽  
Human Neuroblastoma ◽  
Protein Levels ◽  
Effective Doses

Risk assessment of neurotoxicity is mainly based on in vivo exposure, followed by tests on behaviour, physiology and pathology. In this study, an attempt to estimate lowest observed neurotoxic doses after single or repeated dose exposure was performed. Differentiated human neuroblastoma SH-SY5Y cells were exposed to acrylamide, lindane, parathion, paraoxon, phenytoin, diazepam or caffeine for 72 hours. The effects on protein synthesis and intracellular free Ca2+concentration were studied as physiological endpoints. Voltage operated Ca2 +channel function, acetylcholine receptor function and neurite degenerative effects were investigated as neurospecific endpoints for excitability, cholinergic signal transduction and axonopathy, respectively. The general cytotoxicity, determined as the total cellular protein levels after the 72 hours exposure period, was used for comparison to the specific endpoints and for estimation of acute lethality. The lowest concentration that induced 20% effect (EC 20) obtained for each compound, was used as a surrogate for the lowest neurotoxic level (LOEL) at the target site in vivo. The LOELs were integrated with data on adsorption, distribution, metabolism and excretion of the compounds in physiologically-based biokinetic (PBBK) models of the rat and the lowest observed effective doses (LOEDs) were estimated for the test compounds. A good correlation was observed between the estimated LOEDs and experimental LOEDs found in literature for rat for all test compounds, except for diazepam. However, when using in vitro data from the literature on diazepam's effect on gamma-amino butyric acid (GABA)A receptor function for the estimation of LOED, the correlation between the estimated and experimental LOEDs was improved from a 10 000-fold to a 10-fold difference. Our results indicate that it is possible to estimate LOEDs by integrating in vitro toxicity data as surrogates for lowest observed target tissue levels with PBBK models, provided that some knowledge about toxic mechanisms is known. Human & Experimental Toxicology (2007) 26, 333—338

scholarly journals In vitro toxicity evaluation of single walled carbon nanotubes on human A549 lung cells

2007 ◽  
Vol 21 (3) ◽  
pp. 438-448 ◽  
Author(s):  
Maria Davoren ◽  
Eva Herzog ◽  
Alan Casey ◽  
Benjamin Cottineau ◽  
Gordon Chambers ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Single Walled Carbon Nanotubes ◽  
In Vitro Toxicity ◽  
Lung Cells ◽  
Toxicity Evaluation ◽  
Single Walled Carbon ◽  
Walled Carbon Nanotubes ◽  
Human A549 ◽  
A549 Lung

The photodynamic activity and toxicity evaluation of 5,10,15-tris(ethoxylcarbonyl)corrole phosphorus(V) in vivo and in vitro

2019 ◽  
Vol 163 ◽  
pp. 779-786 ◽  
Author(s):  
Zhao Zhang ◽  
Hua-Jun Yu ◽  
Hui Huang ◽  
Hua-Hua Wang ◽  
Shang Wu ◽  
...  
Keyword(s):  
Toxicity Evaluation ◽  
Photodynamic Activity

scholarly journals Synthesis, characterization, in vitro SAR study, and preliminary in vivo toxicity evaluation of naphthylmethyl substituted bis-imidazolium salts

2021 ◽  
Vol 30 ◽  
pp. 115893
Author(s):  
Marie R. Southerland ◽  
Michael A. DeBord ◽  
Nicholas A. Johnson ◽  
Steven R. Crabtree ◽  
Nicolas E. Alexander ◽  
...  
Keyword(s):  
Imidazolium Salts ◽  
Toxicity Evaluation ◽  
In Vivo Toxicity ◽  
Sar Study
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