scholarly journals Oral Administration of Achyranthis radix Extract Prevents TMA-induced Allergic Contact Dermatitis by Regulating Th2 Cytokine and Chemokine Production in Vivo

Molecules ◽  
2015 ◽  
Vol 20 (12) ◽  
pp. 21584-21596 ◽  
Author(s):  
Sung Jung ◽  
Dae Choi ◽  
Da-Ae Kwon ◽  
Min Kim ◽  
Ki Seong ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Oral Administration ◽  
Allergic Contact Dermatitis ◽  
Chemokine Production ◽  
Th2 Cytokine ◽  
Allergic Contact

Red Grape Polyphenol Oral Administration improves Immune Response in Women Affected by Nickel-Mediated Allergic Contact Dermatitis

2020 ◽  
Vol 20 ◽  
Author(s):  
Thea Magrone ◽  
Emilio Jirillo ◽  
Manrico Magrone ◽  
Matteo Antonio Russo ◽  
Paolo Romita ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Oral Administration ◽  
Allergic Contact Dermatitis ◽  
Laboratory Data ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Red Grape ◽  
Allergic Contact ◽  
Drop Outs

Background: Our previous findings demonstrated that in vitro supplementation of polyphenols, extracted from seeds of red grape (Nero di Troia cultivar), to peripheral lymphomonocytes from patients affected by allergic contact dermatitis (ACD) to nickel (Ni) could reduce release of pro-inflammatory cytokines and nitric oxide (NO), while increasing levels of interleukin (IL)-10, an anti-inflammatory cytokine. Objective: To assess whether an intervention with oral administration of polyphenols leads to a reduction of peripheral biomarkers in ACD patients. Method: At T0, 25 patients affected by ACD to Ni were orally administered with 300 mg polyphenols prodie extracted from seeds of red grape (Nero di Troia cultivar) (NATUR-OX®) for 3 months (T1). Other 25 patients affected by ACD to Ni received placebo only for the same period of time. Serum biomarkers were analyzed at T0 and T1. In both groups seven drop outs were recorded. Result: At T1 in comparison to T0, in treated patients, values of IFN-γ, IL-4, IL-17, PTX3 and NO decreased, while IL-10 levels increased when compared with T0 values. Conversely, in placebo-treated patients no modifications of biomarkers were evaluated at T1. Conclusion: Present laboratory data rely on the anti-oxidant, anti-inflammatory and anti-allergic properties of polyphenols.

In vivo induction of regulatory T cells promotes allergen tolerance and suppresses allergic contact dermatitis

2017 ◽  
Vol 261 ◽  
pp. 223-233 ◽  
Author(s):  
Stephen C. Balmert ◽  
Cara Donahue ◽  
John R. Vu ◽  
Geza Erdos ◽  
Louis D. Falo ◽  
...  
Keyword(s):  
T Cells ◽  
Contact Dermatitis ◽  
Regulatory T Cells ◽  
Allergic Contact Dermatitis ◽  
Allergic Contact ◽  
In Vivo Induction

scholarly journals Effect of Cone of Pinus densiflora on DNCB-Induced Allergic Contact Dermatitis-Like Skin Lesion in Balb/c Mice

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 839
Author(s):  
Boguen Kwon ◽  
SooYeon Hong ◽  
Eun-Young Kim ◽  
Jae-Hyun Kim ◽  
Minsun Kim ◽  
...  
Keyword(s):  
T Cells ◽  
Contact Dermatitis ◽  
Skin Lesion ◽  
Allergic Contact Dermatitis ◽  
Pinus Densiflora ◽  
Hacat Cells ◽  
Tnf Α ◽  
Ifn Γ ◽  
Allergic Contact

Cone of Pinus densiflora (CP), or Korean red pinecone, is a cluster of Pinus densiflora fruit. CP has also been verified in several studies to have anti-oxidation, anti-fungal, anti-bacterial, and anti-melanogenic effects. However, anti-inflammatory effects have not yet been confirmed in the inflammatory responses of pinecones to allergic contact dermatitis. The purpose of this study is to prove the anti-inflammatory effect of CP on allergic contact dermatitis (ACD) in vitro and in vivo. CP inhibited the expression of TSLP, TARC, MCP-1, TNF-α, and IL-6 in TNF-α/IFN-γ-stimulated HaCaT cells and MCP-1, GM-CSF, TNF-α, IL-6, and IL-8 in PMACI (phorbol-12-myristate-13-acetate plus A23187)-stimulated HMC-1 cells. CP inhibited the phosphorylation of mitogen-activated protein kinase (MAPKs), as well as the translocation of NF-κB on TNF-α/IFN-γ stimulated in HaCaT cells. In vivo, CP decreased major symptoms of ACD, levels of IL-6 in skin lesion, thickening of the epidermis and dermis, infiltration of eosinophils and mast cells, and the infiltration of CD4+ T cells and CD8+ T cells. This result suggests that CP represents a potential alternative medicine to ACD for diseases such as chronic skin inflammation.

Airborne allergic contact dermatitis caused by Machaerium scleroxylon : Confirmation by in vivo and in vitro tests

2019 ◽  
Vol 81 (4) ◽  
pp. 296-298 ◽  
Author(s):  
Katharina Hansel ◽  
Nicola Murgia ◽  
Anna Russano ◽  
Francesco Crescenzi ◽  
Marta Tramontana ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
In Vitro Tests ◽  
Allergic Contact
Sign in / Sign up

Export Citation Format

Share Document