scholarly journals In Silico Identification and in Vitro Activity of Novel Natural Inhibitors of Trypanosoma brucei Glyceraldehyde-3-phosphate-dehydrogenase

Molecules ◽  
2015 ◽  
Vol 20 (9) ◽  
pp. 16154-16169 ◽  
Author(s):  
Fabian Herrmann ◽  
Mairin Lenz ◽  
Joachim Jose ◽  
Marcel Kaiser ◽  
Reto Brun ◽  
...  
Keyword(s):  
Trypanosoma Brucei ◽  
In Silico ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
In Silico Identification ◽  
Natural Inhibitors

In silico identification and in vitro activity of new pancreatic lipase inhibitors

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
T Buchholz ◽  
A Frank ◽  
G Wolber ◽  
MF Melzig
Keyword(s):  
Pancreatic Lipase ◽  
In Silico ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
In Silico Identification ◽  
Pancreatic Lipase Inhibitors

scholarly journals Anti-onchocerca Metabolites from Cyperus articulatus: Isolation, In Vitro Activity and In Silico ‘Drug-Likeness’

2014 ◽  
Vol 4 (4) ◽  
pp. 243-249 ◽  
Author(s):  
Jonathan Alunge Metuge ◽  
Smith B. Babiaka ◽  
James A. Mbah ◽  
Fidele Ntie-Kang ◽  
Godfred A. Ayimele ◽  
...  
Keyword(s):  
In Silico ◽  
Vitro Activity ◽  
In Vitro Activity

scholarly journals In silico discovery and in vitro activity of inhibitors against Mycobacterium tuberculosis 7,8-diaminopelargonic acid synthase (Mtb BioA)

2017 ◽  
Vol Volume11 ◽  
pp. 563-574 ◽  
Author(s):  
Junie Billones ◽  
Maria Constancia Carrillo ◽  
Voltaire Organo ◽  
Jamie Bernadette Sy ◽  
Nina Abigail Clavio ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
In Silico ◽  
Vitro Activity ◽  
In Vitro Activity

scholarly journals Antitrypanosomal Activities of Proteasome Inhibitors

2002 ◽  
Vol 46 (6) ◽  
pp. 2038-2040 ◽  
Author(s):  
Joseph Nkemgu-Njinkeng ◽  
Vera Rosenkranz ◽  
Michael Wink ◽  
Dietmar Steverding
Keyword(s):  
Drug Development ◽  
Trypanosoma Brucei ◽  
Proteasome Inhibitors ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Data Support ◽  
Nanomolar Range

ABSTRACT Seven peptidyl proteasome inhibitors were tested for in vitro activity against Trypanosoma brucei bloodstream forms. Two compounds showed activity in the low nanomolar range. In general, trypanosomes were more susceptible to the compounds than were human HL-60 cells. The data support the potential of proteasome inhibitors for rational antitrypanosomal drug development.

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