scholarly journals Prazosin-Conjugated Matrices Based on Biodegradable Polymers and α-Amino Acids—Synthesis, Characterization, and in Vitro Release Study

Molecules ◽  
2015 ◽  
Vol 20 (8) ◽  
pp. 14533-14551 ◽  
Author(s):  
Ewa Oledzka ◽  
Anna Sawicka ◽  
Marcin Sobczak ◽  
Grzegorz Nalecz-Jawecki ◽  
Agata Skrzypczak ◽  
...  
Keyword(s):  
Amino Acids ◽  
Biodegradable Polymers ◽  
In Vitro Release ◽  
Release Study ◽  
Vitro Release

Development, in vitro and in vivo Evaluations of Solid-Lipid Microparticles based on Solidified Micellar Carrier System for Oral Delivery of Cefepime

2017 ◽  
Vol 10 (1) ◽  
pp. 3582-3593
Author(s):  
Chukwuebuka Umeyor ◽  
Uchechukwu Nnadozie ◽  
Anthony Attama
Keyword(s):  
Oral Delivery ◽  
In Vitro Release ◽  
Carrier System ◽  
Solid Lipid ◽  
Solid Lipid Microparticles ◽  
Release Study ◽  
Lipid Microparticles ◽  
Vitro Release

This study seeks to formulate and evaluate a solid lipid nanoparticle-based, solidified micellar carrier system for oral delivery of cefepime. Cefepime has enjoyed a lot of therapeutic usage in the treatment of susceptible bacterial infections; however, its use is limited due to its administration as an injection only with poor patient compliance. Since oral drug administration encourage high patient compliance with resultant effect in improved therapy, cefepime was formulated as solid lipid microparticles for oral delivery using the concept of solidified micellar carrier system. The carrier system was evaluated based on particle yield, particle size and morphology, encapsulation efficiency (EE %), and thermal analysis using differential scanning calorimeter (DSC). Preliminary microbiological studies were done using gram positive and negative bacteria. In vitro release study was performed using biorelevant media, while in vivo release study was performed in white albino rats. The yield of solid lipid microparticles (SLM) ranged from 84.2 – 98.0 %. The SLM were spherical with size ranges of 3.8 ± 1.2 to 42.0 ± 1.4 µm. The EE % calculated ranged from 83.6 – 94.8 %. Thermal analysis showed that SLM was less crystalline with high potential for drug entrapment. Microbial studies showed that cefepime retained its broad spectrum anti-bacterial activity. In vitro release showed sustained release of cefepime from SLM, and in vivo release study showed high concentration of cefepime released in the plasma of study rats. The study showed that smart engineering of solidified micellar carrier system could be used to improve oral delivery of cefepime.

Formulation and Evaluation of Sustained Release Dosage Forms of Norfloxacin

2018 ◽  
Vol 11 (6) ◽  
pp. 4331-4337
Author(s):  
C Suja ◽  
Sismy C
Keyword(s):  
Sustained Release ◽  
Guar Gum ◽  
In Vitro Release ◽  
Angle Of Repose ◽  
Prolonged Release ◽  
Weight Variation ◽  
Sustained Release Tablets ◽  
Release Study ◽  
Vitro Release

The goal of this study was to formulate and evaluate norfloxacin sustained release tablets. Norfloxacin sustained release tablets were prepared by wet granulation method using two polymers such as HPMC K 100 M (hydrophilic polymer) and guar gum (natural polymer) and with three polymer ratios (0.5, 1.0 and 1.5). The prepared granules were evaluated to preformulation studies such as angle of repose, bulk density, tapped density, bulkiness, compressibility index and Hauser’s ratio. All the parameters shows that the granules having good flow properties. Then the formulated tablets were taken to evaluation studies such as hardness, weight variation, friability, drug content and thickness. All the parameters were within the acceptable limits. IR spectral analysis showed that there was no interaction between the drug and polymers. The in vitro release study was performed in phosphate buffer pH 7.4 at 293 nm. The in vitro release study showed that if the polymer ratio is increased, then the release of the drug is prolonged. HPMC K 100M shows a prolonged release when compared to guar gum.

Influence of different viscosity grade ethylcellulose polymers on encapsulation and in vitro release study of drug loaded nanoparticles

2013 ◽  
Vol 7 (5) ◽  
pp. 414-420 ◽  
Author(s):  
Amolkumar B. Lokhande ◽  
Satyendra Mishra ◽  
Ravindra D. Kulkarni ◽  
Jitendra B. Naik
Keyword(s):  
In Vitro Release ◽  
Viscosity Grade ◽  
Release Study ◽  
Vitro Release

In Vitro Release Study of Verapamil Hydrochloride Through Sodium Alginate Interpenetrating Monolithic Membranes

2001 ◽  
Vol 27 (10) ◽  
pp. 1107-1114 ◽  
Author(s):  
Mahaveer D. Kurkuri ◽  
Anandrao R. Kulkarni ◽  
Mahadevappa Y. Kariduraganavar ◽  
Tejraj M. Aminabhavi
Keyword(s):  
Sodium Alginate ◽  
In Vitro Release ◽  
Verapamil Hydrochloride ◽  
Release Study ◽  
Vitro Release

Physicochemical properties and in-vitro release study of CFLE-chitosan microsphere beads

2019 ◽  
Vol 26 (12) ◽  
Author(s):  
Vandana Suryavanshi ◽  
Preeti K. Suresh ◽  
Chayan Das ◽  
Tungabidya Maharana
Keyword(s):  
Physicochemical Properties ◽  
In Vitro Release ◽  
Chitosan Microsphere ◽  
Release Study ◽  
Vitro Release

scholarly journals Synthesis, characterization and in vitro release study of efavirenz-loaded chitosan nanoparticle

2020 ◽  
Author(s):  
R. Rozana ◽  
Y. Yulizar ◽  
A. Saefumillah ◽  
D. O. B. Apriandanu
Keyword(s):  
In Vitro Release ◽  
Chitosan Nanoparticle ◽  
Release Study ◽  
Vitro Release

Characterisation, in vitro release study, and antibacterial activity of montmorillonite-gentamicin complex material

2017 ◽  
Vol 70 ◽  
pp. 471-478 ◽  
Author(s):  
A. Rapacz-Kmita ◽  
M.M. Bućko ◽  
E. Stodolak-Zych ◽  
M. Mikołajczyk ◽  
P. Dudek ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
In Vitro Release ◽  
Complex Material ◽  
Release Study ◽  
Vitro Release

scholarly journals Preparation of a Sustained Release Drug Delivery System for Dexamethasone by a Thermosensitive, In Situ Forming Hydrogel for Use in Differentiation of Dental Pulp

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Elham Khodaverdi ◽  
Fatemeh Kheirandish ◽  
Farnaz Sadat Mirzazadeh Tekie ◽  
Bibi Zahra Khashyarmanesh ◽  
Farzin Hadizadeh ◽  
...  
Keyword(s):  
Phase Transition ◽  
Transition Temperature ◽  
Phase Transition Temperature ◽  
Delivery System ◽  
In Vitro Release ◽  
In Situ Forming ◽  
Release Study ◽  
Vitro Release

In situ forming delivery systems composed of block copolymers are attracting substantial attention due to their ease of use, biocompatibility, and biodegradability. In this study, the thermoresponsive triblock copolymer PLGA-PEG-PLGA was studied as a dexamethasone delivery system. Dexamethasone, a synthetic glucocorticoid, is used clinically to improve inflammation, pain, and the hyperemesis of chemotherapy, and it is applied experimentally as a differentiation factor in tissue engineering. PLGA-PEG-PLGA was synthesised under microwave irradiation for 5 min. The obtained copolymer was characterised to determine its structure and phase transition temperature. An in vitro release study was conducted for various copolymer structures and drug concentrations. The yield of the reaction and HNMR analysis confirmed the appropriateness of the microwave-assisted method for PLGA-PEG-PLGA synthesis. Phase transition temperature was affected by the drug molecule as well as by the copolymer concentration and structure. An in vitro release study demonstrated that release occurs mainly by diffusion and does not depend on the copolymer structure or dexamethasone concentration.

THE IN VITRO RELEASE OF AMINO ACIDS BY RUMEN PAPILLAE

1980 ◽  
Vol 60 (2) ◽  
pp. 281-291 ◽  
Author(s):  
R. J. BOILA ◽  
L. P. MILLIGAN
Keyword(s):  
Amino Acids ◽  
Carbon Sources ◽  
In Vitro Release ◽  
Nitrogen Sources ◽  
Chromatographic Technique ◽  
Salts Of Organic Acids ◽  
Liquid Chromatographic ◽  
Vitro Release ◽  
Effective Source

Rumen papillae from cattle were incubated aerobically with combinations of NH4Cl, amino acids and salts of organic acids, the latter including propionate, pyruvate, α-ketoglutarate and glyoxylate. Amino acids in the incubation media were analyzed using a gas-liquid chromatographic technique entailing separation of the isobutyl-N(0)-heptafluorobutyryl esters: glutamine was recovered with glutamate, asparagine with aspartate, and citrulline with ornithine. Rumen papillae incubated with pyruvate or propionate released alanine, but with the latter substrate only glutamate was effective as a nitrogen source. Glycine and glutamate plus glutamine were released in the presence of glyoxylate and α-ketoglutarate, respectively. Serine and aspartate plus asparagine were not quantitatively major products released by rumen papillae. Glutamate was an effective source of nitrogen for the release of alanine and glycine with pyruvate and glyoxylate, respectively, as carbon sources. When rumen papillae were incubated with pyruvate or glyoxylate as the added carbon source, glutamine nitrogen disappeared and was not accounted for by the amino acids measured. With arginine as a substrate, there was a release of ornithine by rumen papillae indicating urea production. The tissues of rumen papillae appear to synthesize amino acids from expected carbon sources with ammonia or glutamate as nitrogen sources and to catabolize glutamine and arginine. The metabolism of amino acids by rumen papillae would contribute to the interchange of nitrogen between the rumen and the host.

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