scholarly journals Glycoprotein Quality Control and Endoplasmic Reticulum Stress

Molecules ◽  
2015 ◽  
Vol 20 (8) ◽  
pp. 13689-13704 ◽  
Author(s):  
Qian Wang ◽  
Jody Groenendyk ◽  
Marek Michalak
Keyword(s):  
Quality Control ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Glycoprotein Quality Control

The roles of mitochondria-associated membranes in mitochondrial quality control under endoplasmic reticulum stress

Life Sciences ◽  
2019 ◽  
Vol 231 ◽  
pp. 116587 ◽  
Author(s):  
Beiwu Lan ◽  
Yichun He ◽  
Hongyu Sun ◽  
Xinzi Zheng ◽  
Yufei Gao ◽  
...  
Keyword(s):  
Quality Control ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Mitochondrial Quality Control

scholarly journals Endoplasmic Reticulum Glycoprotein Quality Control Regulates CD1d Assembly and CD1d-mediated Antigen Presentation

2013 ◽  
Vol 288 (23) ◽  
pp. 16391-16402 ◽  
Author(s):  
Amit Kunte ◽  
Wei Zhang ◽  
Crina Paduraru ◽  
Natacha Veerapen ◽  
Liam R. Cox ◽  
...  
Keyword(s):  
Quality Control ◽  
Endoplasmic Reticulum ◽  
Control Process ◽  
Adaptive Immune ◽  
Histocompatibility Complex ◽  
Quality Control Process ◽  
Exogenous Antigen ◽  
And Function ◽  
Glycoprotein Quality Control

The non-classical major histocompatibility complex (MHC) homologue CD1d presents lipid antigens to innate-like lymphocytes called natural-killer T (NKT) cells. These cells, by virtue of their broad cytokine repertoire, shape innate and adaptive immune responses. Here, we have assessed the role of endoplasmic reticulum glycoprotein quality control in CD1d assembly and function, specifically the role of a key component of the quality control machinery, the enzyme UDP glucose glycoprotein glucosyltransferase (UGT1). We observe that in UGT1-deficient cells, CD1d associates prematurely with β2-microglobulin (β2m) and is able to rapidly exit the endoplasmic reticulum. At least some of these CD1d-β2m heterodimers are shorter-lived and can be rescued by provision of a defined exogenous antigen, α-galactosylceramide. Importantly, we show that in UGT1-deficient cells the CD1d-β2m heterodimers have altered antigenicity despite the fact that their cell surface levels are unchanged. We propose that UGT1 serves as a quality control checkpoint during CD1d assembly and further suggest that UGT1-mediated quality control can shape the lipid repertoire of newly synthesized CD1d. The quality control process may play a role in ensuring stability of exported CD1d-β2m complexes, in facilitating presentation of low abundance high affinity antigens, or in preventing deleterious responses to self lipids.

scholarly journals Reconstructed glycan profile for evaluation of operating status of the endoplasmic reticulum glycoprotein quality control

Glycobiology ◽  
2012 ◽  
Vol 23 (1) ◽  
pp. 121-131 ◽  
Author(s):  
S. Iwamoto ◽  
M. Isoyama ◽  
M. Hirano ◽  
K. Yamaya ◽  
Y. Ito ◽  
...  
Keyword(s):  
Quality Control ◽  
Endoplasmic Reticulum ◽  
Glycan Profile ◽  
Glycoprotein Quality Control
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