scholarly journals Effect of Diterpenes Isolated of the Marine Alga Canistrocarpus cervicornis against Some Toxic Effects of the Venom of the Bothrops jararaca Snake

Molecules ◽  
2015 ◽  
Vol 20 (3) ◽  
pp. 3515-3526 ◽  
Author(s):  
Thaisa Domingos ◽  
Magui Vallim ◽  
Diana Cavalcanti ◽  
Eládio Sanchez ◽  
Valéria Teixeira ◽  
...  
Keyword(s):  
Marine Alga ◽  
Toxic Effects ◽  
Bothrops Jararaca ◽  
Canistrocarpus Cervicornis

scholarly journals Corrigendum to “Potential use of extract of the plant Schwartiza brasiliensis (choisy) bedell exgir.-Cañas against the toxic effects of the venom of Bothrops jararaca or B. jararacussu” [Biomed. Pharmacother. 125 (2020) 109951]

2021 ◽  
pp. 112285
Author(s):  
Jenifer Frouche de Souza ◽  
Eduardo Coriolano de Oliveira ◽  
Ana Cláudia Rodrigues da Silva ◽  
Vagner Pereira da Silva ◽  
Maria Auxiliadora Coelho Kaplan ◽  
...  
Keyword(s):  
Toxic Effects ◽  
Bothrops Jararaca ◽  
Potential Use

Anti-HIV-1 activity of compounds derived from marine alga Canistrocarpus cervicornis

2015 ◽  
Vol 28 (4) ◽  
pp. 2523-2527 ◽  
Author(s):  
Caroline de Souza Barros ◽  
Claudio Cesar Cirne-Santos ◽  
Valeria Garrido ◽  
Ingrid Barcelos ◽  
Paulo Roberto Soares Stephens ◽  
...  
Keyword(s):  
Marine Alga ◽  
Anti Hiv ◽  
Canistrocarpus Cervicornis ◽  
Hiv 1

scholarly journals Potential use of extract of the plant Schwartiza brasiliensis (choisy) bedell ex gir.-Cañas against the toxic effects of the venom of Bothrops jararaca or B. jararacussu

2020 ◽  
Vol 125 ◽  
pp. 109951 ◽  
Author(s):  
Jenifer Frouche de Souza ◽  
Eduardo Coriolano de Oliveira ◽  
Ana Cláudia Rodrigues da Silva ◽  
Vagner Pereira da Silva ◽  
Maria Auxiliadora Coelho Kaplan ◽  
...  
Keyword(s):  
Toxic Effects ◽  
Bothrops Jararaca ◽  
Potential Use

Therapeutic efficacy in BALB/C mice of extract from marine alga Canistrocarpus cervicornis (Phaeophyceae) against herpes simplex virus type 1

2016 ◽  
Vol 29 (2) ◽  
pp. 769-773 ◽  
Author(s):  
Caroline de Souza Barros ◽  
Valeria Garrido ◽  
Vanessa Melchiades ◽  
Rafaela Gomes ◽  
Max Willian Lisboa Gomes ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Therapeutic Efficacy ◽  
Marine Alga ◽  
Simplex Virus ◽  
Canistrocarpus Cervicornis

Utilization of the Plant Clusia Fluminensis Planch & Triana Against Some Toxic Activities of the Venom of Bothrops jararaca and B. jararacussu Snake Venom Toxic Activities

2019 ◽  
Vol 19 (22) ◽  
pp. 1990-2002 ◽  
Author(s):  
Aldo Rodrigues da Silva ◽  
Maria Carolina Anholeti ◽  
Marcia Pietroluongo ◽  
Eladio Flores Sanchez ◽  
Alessandra Leda Valverde ◽  
...  
Keyword(s):  
Toxic Effects ◽  
Detailed Knowledge ◽  
Aqueous Extracts ◽  
Tissue Necrosis ◽  
Experimental Protocol ◽  
Fruit Extract ◽  
Limited Efficacy ◽  
Bothrops Jararaca

Background: In Brazil, the Bothrops genus accounts for 87% of registered snakebites, which are characterized by hemorrhage, tissue necrosis, hemostatic disturbances, and death. The treatment recommended by governments is the administration of specific antivenoms. Although antivenom efficiently prevents venom-induced lethality, it has limited efficacy in terms of preventing local tissue damage. Thus, researchers are seeking alternative therapies able to inhibit the main toxic effects of venoms, without compromising safety. Objective: The study aimed to test the ability of aqueous extracts of leaves, stems, and fruits of the plant Clusia fluminensis to neutralize some toxic effects induced by the venoms of Bothrops jararaca and Bothrops jararacussu. Methods: The plant extracts were incubated with venoms for 30 min. at 25 °C, and then in vitro (coagulant and proteolytic) and in vivo (hemorrhagic, myotoxic, and edematogenic) activities were evaluated. In addition, the extracts were administered to animals (by oral, intravenous or subcutaneous routes) before or after the injection of venom samples, and then hemorrhage and edema assays were performed. In addition, a gel solution of the fruit extract was produced and tested in terms of reducing hemorrhage effects. A chemical prospection was performed to identify the main classes of compounds present in the extracts. Results: All the extracts inhibited the activities of the two venoms, regardless of the experimental protocol or route of administration of the extracts. Moreover, the gel of the fruit extract inhibited the venom-induced-hemorrhage. The extracts comprised of tannins, flavonoids, saponins, steroids, and terpenoids. Conclusion: Antivenom properties of C. fluminensis extracts deserve further investigation in order to gain detailed knowledge regarding the neutralization profile of these extracts.

Ultrastructure of the effect of T-514 obtained from Karwinskia humboldtiana on assembly and integrity of yeast's peroxisomes

1991 ◽  
Vol 49 ◽  
pp. 136-137
Author(s):  
J. Sepulveda-Saavedra ◽  
I. Vander-Klei ◽  
M. Venhuis ◽  
Y. Piñeyro-Lopez
Keyword(s):  
Culture Conditions ◽  
Toxic Effects ◽  
Candida Boidinii ◽  
Central Mexico ◽  
Poisonous Plant ◽  
Biological Behaviour ◽  
Enzyme Content ◽  
Fat Deposits ◽  
Yeast Model

Karwinskia humboldtiana is a poisonous plant that grows in semi desertic areas in north and central México. It produces several substances with different toxic effects. One of them designated T-514 damages severely the lung, kidney and liver, producing in the hepatoeyte large intracellular fat deposits and necrosis. Preliminary observations demonstrated that three is a decrease in the amount of peroxisomes in the hepatocytes of experimentally intoxicated rats and monkeys. To study the effect exerted by the T-514 on peroxisomes, a yeast model was selected, thus, three species: Saccha romices cerevisiae, Ilansenula polymorpha and Candida boidinii were used, because there is information concerning their peroxisome's morphology, enzyme content, biological behaviour under different culture conditions and biogenesis.

Some Conditions Necessary for Pinocytosis

1968 ◽  
Vol 26 ◽  
pp. 142-143
Author(s):  
M. W. Brightman
Keyword(s):  
Smooth Muscle ◽  
Cell Membrane ◽  
Toxic Effects ◽  
Cytological Evidence ◽  
Cell Processes

The cytological evidence for pinocytosis is the focal infolding of the cell membrane to form surface pits that eventually pinch off and move into the cytoplasm. This activity, which can be inhibited by oxidative and glycolytic poisons, is performed only by cell processes that are at least 300A wide. However, the interpretation of such toxic effects becomes equivocal if the membrane invaginations do not normally lead to the formation of migratory vesicles, as in some endothelia and in smooth muscle. The present study is an attempt to set forth some conditions under which pinocytosis, as distinct from the mere inclusion of material in surface invaginations, can take place.

Toxic effects of aerosol propellants on the heart

1973 ◽  
Vol 131 (1) ◽  
pp. 162-166 ◽  
Author(s):  
W. S. Harris
Keyword(s):  
Toxic Effects
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