scholarly journals Ag+ as a More Effective Elicitor for Production of Tanshinones than Phenolic Acids in Salvia miltiorrhiza Hairy Roots

Molecules ◽  
2014 ◽  
Vol 20 (1) ◽  
pp. 309-324 ◽  
Author(s):  
Bingcong Xing ◽  
Dongfeng Yang ◽  
Wanli Guo ◽  
Zongsuo Liang ◽  
Xijun Yan ◽  
...  
Keyword(s):  
Phenolic Acids ◽  
Hairy Roots ◽  
Salvia Miltiorrhiza

scholarly journals Diterpenoid Tanshinones and Phenolic Acids from Cultured Hairy Roots of Salvia miltiorrhiza Bunge and Their Antimicrobial Activities

Molecules ◽  
2011 ◽  
Vol 16 (3) ◽  
pp. 2259-2267 ◽  
Author(s):  
Jianglin Zhao ◽  
Jingfeng Lou ◽  
Yan Mou ◽  
Peiqin Li ◽  
Jianyong Wu ◽  
...  
Keyword(s):  
Phenolic Acids ◽  
Hairy Roots ◽  
Salvia Miltiorrhiza ◽  
Antimicrobial Activities ◽  
Salvia Miltiorrhiza Bunge

Regulation of folic acid on phenolic acids production in Salvia miltiorrhiza hairy roots

2016 ◽  
Vol 127 (1) ◽  
pp. 175-185 ◽  
Author(s):  
Dongfeng Yang ◽  
Zhicheng Huang ◽  
Bingcong Xing ◽  
Weibo Jin ◽  
Xijun Yan ◽  
...  
Keyword(s):  
Folic Acid ◽  
Phenolic Acids ◽  
Hairy Roots ◽  
Salvia Miltiorrhiza

SmbHLH3 acts as a transcription repressor for both phenolic acids and tanshinone biosynthesis in Salvia miltiorrhiza hairy roots

2020 ◽  
Vol 169 ◽  
pp. 112183 ◽  
Author(s):  
Chenlu Zhang ◽  
Bingcong Xing ◽  
Dongfeng Yang ◽  
Min Ren ◽  
Hui Guo ◽  
...  
Keyword(s):  
Phenolic Acids ◽  
Hairy Roots ◽  
Salvia Miltiorrhiza

Phosphate starvation promoted the accumulation of phenolic acids by inducing the key enzyme genes in Salvia miltiorrhiza hairy roots

2016 ◽  
Vol 35 (9) ◽  
pp. 1933-1942 ◽  
Author(s):  
Lin Liu ◽  
DongFeng Yang ◽  
TongYao Liang ◽  
HaiHua Zhang ◽  
ZhiGui He ◽  
...  
Keyword(s):  
Phenolic Acids ◽  
Hairy Roots ◽  
Salvia Miltiorrhiza ◽  
Phosphate Starvation ◽  
Key Enzyme

Overexpression of SmbHLH148 induced biosynthesis of tanshinones as well as phenolic acids in Salvia miltiorrhiza hairy roots

2018 ◽  
Vol 37 (12) ◽  
pp. 1681-1692 ◽  
Author(s):  
Bingcong Xing ◽  
Lijun Liang ◽  
Lin Liu ◽  
Zhuoni Hou ◽  
Dongfeng Yang ◽  
...  
Keyword(s):  
Phenolic Acids ◽  
Hairy Roots ◽  
Salvia Miltiorrhiza

scholarly journals Multiplexed CRISPR/Cas9-Mediated Knockout of Laccase Genes in Salvia miltiorrhiza Revealed Their Roles in Growth, Development, and Metabolism

2021 ◽  
Vol 12 ◽  
Author(s):  
Zheng Zhou ◽  
Qing Li ◽  
Liang Xiao ◽  
Yun Wang ◽  
Jingxian Feng ◽  
...  
Keyword(s):  
Phenolic Acids ◽  
Hairy Roots ◽  
Cross Sections ◽  
Phenolic Acid ◽  
Lignin Content ◽  
Salvia Miltiorrhiza ◽  
Acid Biosynthesis ◽  
Disease Treatment ◽  
In The Wild ◽  
Laccase Genes

Laccases are multicopper-containing glycoproteins related to monolignol oxidation and polymerization. These properties indicate that laccases may be involved in the formation of important medicinal phenolic acid compounds in Salvia miltiorrhiza such as salvianolic acid B (SAB), which is used for cardiovascular disease treatment. To date, 29 laccases have been found in S. miltiorrhiza (SmLACs), and some of which (SmLAC7 and SmLAC20) have been reported to influence the synthesis of phenolic acids. Because of the functional redundancy of laccase genes, their roles in S. miltiorrhiza are poorly understood. In this study, the CRISPR/Cas9 system was used for targeting conserved domains to knockout multiple genes of laccase family in S. miltiorrhiza. The expressions of target laccase genes as well as the phenolic acid biosynthesis key genes decrease dramatically in editing lines. Additionally, the growth and development of hairy roots was significantly retarded in the gene-edited lines. The cross-sections examination of laccase mutant hairy roots showed that the root development was abnormal and the xylem cells in the edited lines became larger and looser than those in the wild type. Additionally, the accumulation of RA as well as SAB was decreased, and the lignin content was nearly undetectable. It suggested that SmLACs play key roles in development and lignin formation in the root of S. miltiorrhiza and they are necessary for phenolic acids biosynthesis.

scholarly journals Integration of Gene-to-Metabolite Networks for Understanding Global Responses of Phenolic Acids Biosynthesis in Salvia miltiorrhiza

Planta Medica ◽  
2009 ◽  
Vol 75 (04) ◽  
Author(s):  
Y Xiao ◽  
B Yi ◽  
YB Duan ◽  
JF Chen ◽  
Y Liu ◽  
...  
Keyword(s):  
Phenolic Acids ◽  
Salvia Miltiorrhiza

Effects of cerous nitrate on growth and tanshinone production in salvia miltiorrhiza hairy roots

2015 ◽  
Vol 33 (11) ◽  
pp. 1228-1235 ◽  
Author(s):  
Mingyu HAN ◽  
Wanli GUO ◽  
Zongsuo LIANG ◽  
Dongfeng YANG ◽  
Xijun YAN ◽  
...  
Keyword(s):  
Hairy Roots ◽  
Salvia Miltiorrhiza ◽  
Cerous Nitrate

The AP2/ERF transcription factor SmERF1L1 regulates the biosynthesis of tanshinones and phenolic acids in Salvia miltiorrhiza

2019 ◽  
Vol 274 ◽  
pp. 368-375 ◽  
Author(s):  
Qiang Huang ◽  
Meihong Sun ◽  
Tingpan Yuan ◽  
Yu Wang ◽  
Min Shi ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Phenolic Acids ◽  
Salvia Miltiorrhiza ◽  
Erf Transcription Factor
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