scholarly journals Design, Synthesis and SAR Study of Novel Trisubstituted Pyrimidine Amide Derivatives as CCR4 Antagonists

Molecules ◽  
2014 ◽  
Vol 19 (3) ◽  
pp. 3539-3551 ◽  
Author(s):  
Libao Xu ◽  
Yang Zhang ◽  
Wenjie Dai ◽  
Ying Wang ◽  
Dan Jiang ◽  
...  
Keyword(s):  
Design Synthesis ◽  
Amide Derivatives ◽  
Sar Study

scholarly journals Novel Acetohydrazide Pyrazole Derivatives: Design, Synthesis, Characterization and Antimicrobial Activity

2019 ◽  
Vol 31 (12) ◽  
pp. 2740-2744
Author(s):  
Anil Verma ◽  
Vinod Kumar ◽  
Ramesh Kataria ◽  
Joginder Singh
Keyword(s):  
Mass Spectrometry ◽  
Antimicrobial Activity ◽  
Antimicrobial Agents ◽  
Antimicrobial Activities ◽  
Pyrazole Derivatives ◽  
Reaction Conditions ◽  
Design Synthesis ◽  
Structure Activity ◽  
Electron Withdrawing Group ◽  
Sar Study

Eleven acetohydrazide linked pyrazole derivatives were designed and synthesized via condensation of acetohyadrazide with different substituted formyl pyrazole derivatives under mild reaction conditions. Synthesized compounds were characterized on the basis of IR, NMR (1H & 13C) and mass spectrometry. The antimicrobial activities of all the compounds were screened against four bacterial and two fungal strains. Among the synthesized compounds, three compounds viz. 6b, 6c and 6d were found as efficient antimicrobial agents in reference to the standard drugs viz. ciprofloxacin and amphotericin-B. Further, structure-activity relationship (SAR) study revealed that electron-withdrawing group enhances the antimicrobial potential of synthesized derivatives as compared to other groups present in the ring. Hence, among compounds 6b-c, compound 6d could be explored further against other microbes to prove its vitality.

Design, synthesis and nematicidal activitives of trifluorobutene amide derivatives against Meloidogyne incognita

2021 ◽  
Vol 40 ◽  
pp. 127917
Author(s):  
Haiping Yang ◽  
Ruifeng Zhang ◽  
Zhong Li ◽  
Peter Maienfisch ◽  
Xiaoyong Xu
Keyword(s):  
Meloidogyne Incognita ◽  
Design Synthesis ◽  
Amide Derivatives

Amide derivatives of 4-azaindole: Design, synthesis, and EGFR targeting anticancer agents

2019 ◽  
Vol 50 (1) ◽  
pp. 71-84 ◽  
Author(s):  
Puli Venkat Swamy ◽  
Vukoti Kiran Kumar ◽  
Ruddarraju Radhakrishnam Raju ◽  
Regalla Venkata Reddy ◽  
Anindita Chatterjee ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Design Synthesis ◽  
Amide Derivatives ◽  
Derivatives Of

Design, synthesis and biological activity of novel substituted pyrazole amide derivatives targeting EcR/USP receptor

2016 ◽  
Vol 27 (4) ◽  
pp. 566-570 ◽  
Author(s):  
Xi-Le Deng ◽  
Jin Xie ◽  
Yong-Qiang Li ◽  
De-Kai Yuan ◽  
Xue-Ping Hu ◽  
...  
Keyword(s):  
Biological Activity ◽  
Design Synthesis ◽  
Amide Derivatives

Design, synthesis and evaluation of calix[4]arene-based carbonyl amide derivatives with antitumor activities

2021 ◽  
Vol 210 ◽  
pp. 112984
Author(s):  
Lin An ◽  
Chan Wang ◽  
You-Guang Zheng ◽  
Jia-dong Liu ◽  
Tong-hui Huang
Keyword(s):  
Antitumor Activities ◽  
Design Synthesis ◽  
Amide Derivatives

scholarly journals Design, Synthesis, and Bioactivity Evaluation of Novel Isoxazole-Amide Derivatives Containing an Acylhydrazone Moiety as New Active Antiviral Agents

Molecules ◽  
2019 ◽  
Vol 24 (20) ◽  
pp. 3766
Author(s):  
Zai-Bo Yang ◽  
Pei Li ◽  
Yin-Ju He
Keyword(s):  
Enzyme Activity ◽  
Mosaic Virus ◽  
Antiviral Agents ◽  
Plant Tolerance ◽  
Design Synthesis ◽  
Amide Derivatives ◽  
Induce Resistance ◽  
Antiviral Activities ◽  
Related Enzyme

As a continuation of our efforts to discover and develop “me-better” active molecules, in this study, a series of novel isoxazole-amide derivatives containing an acylhydrazone moiety were synthesized and evaluated for their antiviral activities against tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV). Antiviral bioassays indicated that some of the target compounds exhibited better in vivo antiviral activities against TMV and CMV than those of Ningnanmycin (NNM). Especially, the compound 7t exhibited the best curative, protection, and inactivation activities against TMV and CMV which were superior to those of NNM. Meanwhile, our present work also revealed that compound 7t could enhance the defense-related enzyme activity and increase the chlorophyll content in tobacco leaves to induce resistance and enhance plant tolerance to TMV infection.

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