scholarly journals Three New Clerodane Diterpenes from Polyalthia longifolia var. pendula

Molecules ◽  
2014 ◽  
Vol 19 (2) ◽  
pp. 2049-2060 ◽  
Author(s):  
Tung-Ho Wu ◽  
Yung-Yi Cheng ◽  
Chao-Jung Chen ◽  
Lean-Teik Ng ◽  
Li-Chen Chou ◽  
...  
Keyword(s):  
Clerodane Diterpenes ◽  
Polyalthia Longifolia

scholarly journals Antimicrobial Evaluation of Clerodane Diterpenes from Polyalthia Longifolia Var. Pendula

2009 ◽  
Vol 4 (3) ◽  
pp. 1934578X0900400 ◽  
Author(s):  
Koneni V. Sashidhara ◽  
Suriya P. Singh ◽  
P.K. Shukla
Keyword(s):  
Antimicrobial Activity ◽  
Sporothrix Schenckii ◽  
Ethanolic Extract ◽  
Phytochemical Investigation ◽  
Clerodane Diterpenes ◽  
Antimicrobial Evaluation ◽  
Clerodane Diterpenoids ◽  
Polyalthia Longifolia ◽  
First Time ◽  
Mic Value

Phytochemical investigation of the ethanolic extract of leaves of Polyalthia longifolia var. pendula has led to the isolation of seven clerodane diterpenoids and five alkaloids. (-)-14, 15-bisnor-3, 11 E-kolavadien-13-one (1), (-)-16-oxocleroda-3,13(14) E-dien-15-oic acid (2), (-)-16α-hydroxycleroda-3,13 (14) Z-dien-15,16-olide (3), (+)-(4→2)-abeo-16(R/S)-2, 13 Z-kolavadien-15, 16-olide-3-al (4), (-)-3β, 16α-dihydroxycleroda-4(18), 13(14) Z-dien45,16-olide (5), (-)-3, 12 E-kolavadien-15-oic acid-16-al (6), (-)-labd-13 E-en-8-ol-15-oic acid (7), liriodenine (8), (-)-anonaine (9), (+)-isoboldine (10), (-)-asimilobine (11) and hordenine (12) have been isolated. This is the first report of 1, 6 and 10 from this plant species while 12 is reported for first time from this genus. Clerodane derivatives 1-7 were evaluated for their antimicrobial activity. Diterpene 3 was found to be most potent agent with MIC value of 6.25 μg/mL against Staphylococcus aureus and Sporothrix schenckii.

scholarly journals Clerodane Diterpenes Isolated from Polyalthia longifolia Induce Apoptosis in Human Leukemia HL-60 Cells

2013 ◽  
Vol 62 (10) ◽  
pp. 843-848 ◽  
Author(s):  
Dina Permata Sari ◽  
Masayuki Ninomiya ◽  
Mai Efdi ◽  
Adlis Santoni ◽  
Sanusi Ibrahim ◽  
...  
Keyword(s):  
Human Leukemia ◽  
Clerodane Diterpenes ◽  
Polyalthia Longifolia

Antileishmanial and Antimicrobial Clerodane Diterpenes from Polyalthia longifolia

Planta Medica ◽  
2013 ◽  
Vol 79 (05) ◽  
Author(s):  
J Zhang ◽  
SK Jain ◽  
MR Jacob ◽  
BL Tekwani ◽  
CD Hufford ◽  
...  
Keyword(s):  
Clerodane Diterpenes ◽  
Polyalthia Longifolia

scholarly journals Dual COX and 5-LOX inhibition by clerodane diterpenes from seeds of Polyalthia longifolia (Sonn.) Thwaites

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ha Thi Nguyen ◽  
Thien-Y. Vu ◽  
Vishala Chandi ◽  
Haritha Polimati ◽  
Vinay Bharadwaj Tatipamula
Keyword(s):  
Underlying Mechanism ◽  
Study Results ◽  
Clerodane Diterpenes ◽  
In Silico Study ◽  
Dual Inhibitors ◽  
Cox 2 ◽  
Lox Inhibitors ◽  
Polyalthia Longifolia ◽  
Cox 1

Abstract Natural metabolites with their specific bioactivities are being considered as a potential source of materials for pharmacological studies. In this study, we successfully isolated and identified five known clerodane diterpenes, namely 16-oxo-cleroda-3,13(14)E-dien-15-oic acid (1), 16-hydroxy-cleroda-3,13-dien-15-oic acid (2), 16-hydroxy-cleroda-4(18),13-dien-16,15-olide (3), 3α,16α-dihydroxy-cleroda-4(18),13(14)Z-dien-15,16-olide (4), and 16α-hydroxy-cleroda-3,13(14)Z-dien-15,16-olide (5) from the methanolic extract of seeds of Polyalthia longifolia. Initially, all the isolated metabolites were investigated for COX-1, COX-2, and 5-LOX inhibitory activities using the standard inhibitory kits. Of which, compounds 3, 4, and 5 exhibited to be potent COX-1, COX-2, and 5-LOX inhibitors with the IC50 values similar or lower to those of the reference drugs. To understand the underlying mechanism, these compounds were subjected to molecular docking on COX-1, COX-2, and 5-LOX proteins. Interestingly, the in silico study results were in high accordance with in vitro studies where compounds 3, 4, and 5 hits assumed interactions and binding pattern comparable to that of reference drugs (indomethacin and diclofenac), as a co-crystallized ligand explaining their remarkable dual (COX/LOX) inhibitor actions. Taken together, our findings demonstrated that compounds 3, 4, and 5 functioned as dual inhibitors of COX/5-LOX and can contribute to the development of novel, more effective anti-inflammatory drugs with minimal side-effects.

Antileishmanial and Antimicrobial Clerodane Diterpenes from Polyalthia longifolia

Planta Medica ◽  
2013 ◽  
Vol 79 (10) ◽  
Author(s):  
J Zhang ◽  
SK Jain ◽  
MR Jacob ◽  
BL Tekwani ◽  
CD Hufford ◽  
...  
Keyword(s):  
Clerodane Diterpenes ◽  
Polyalthia Longifolia

Clerodane diterpenes from Polyalthia longifolia var. pendula protect SK-N-MC human neuroblastoma cells from β-amyloid insult

RSC Advances ◽  
2014 ◽  
Vol 4 (45) ◽  
pp. 23707-23712 ◽  
Author(s):  
Tung-Ho Wu ◽  
Yung-Yi Cheng ◽  
Jing-Ru Liou ◽  
Tzong-Der Way ◽  
Chao-Jung Chen ◽  
...  
Keyword(s):  
Methanolic Extract ◽  
Neuroblastoma Cells ◽  
Neuroprotective Activity ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma ◽  
Hexane Layer ◽  
Clerodane Diterpenes ◽  
Β Amyloid ◽  
Polyalthia Longifolia

The n-hexane layer of Polyalthia longifolia methanolic extract showed neuroprotective activity, resulting in the isolation of three new clerodane diterpenes.

Structural Properties and Antimicrobial Activities of Polyalthia longifolia Leaf Extract-Mediated CuO Nanoparticles

2021 ◽  
Author(s):  
Pravinkumar Nagore ◽  
Suresh Ghotekar ◽  
Kanchan Mane ◽  
Amol Ghoti ◽  
Muhammad Bilal ◽  
...  
Keyword(s):  
Structural Properties ◽  
Leaf Extract ◽  
Antimicrobial Activities ◽  
Cuo Nanoparticles ◽  
Polyalthia Longifolia
Sign in / Sign up

Export Citation Format

Share Document