Synthesis and Dual Histamine H1 and H2 Receptor Antagonist Activity of Cyanoguanidine Derivatives

Bassem Sadek; Rudi Alisch; Armin Buschauer; Sigurd Elz

doi:10.3390/molecules181114186

Synthesis and Dual Histamine H1 and H2 Receptor Antagonist Activity of Cyanoguanidine Derivatives

Molecules ◽

10.3390/molecules181114186 ◽

2013 ◽

Vol 18 (11) ◽

pp. 14186-14202 ◽

Cited By ~ 7

Author(s):

Bassem Sadek ◽

Rudi Alisch ◽

Armin Buschauer ◽

Sigurd Elz

Keyword(s):

Receptor Antagonist ◽

H2 Receptor Antagonist ◽

Antagonist Activity ◽

H2 Receptor

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Influence of urea-equivalent groups in position 5 of 2-amino, 2-(1-aminoethylidenamino) and 2-guanidino thiazole derivatives on H2-receptor antagonist activity in gastric fistula cat

Agents and Actions ◽

10.1007/bf02222236 ◽

1989 ◽

Vol 27 (1-2) ◽

pp. 192-194 ◽

Cited By ~ 1

Author(s):

M. Chiavarini ◽

G. Morini ◽

E. Barocelli ◽

F. Bordi ◽

P. V. Plazzi ◽

...

Keyword(s):

Receptor Antagonist ◽

Gastric Fistula ◽

Thiazole Derivatives ◽

H2 Receptor Antagonist ◽

Antagonist Activity ◽

H2 Receptor

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Effects of drugs combining H1 and H2 receptor antagonist activity on histamine release and life threatening anaphylactoid reactions in pigs

Agents and Actions ◽

10.1007/bf01996488 ◽

1993 ◽

Vol 38 (3-4) ◽

pp. C286-C288 ◽

Cited By ~ 1

Author(s):

B. Stinner ◽

C. Hasse ◽

W. Lorenz ◽

R. Alich ◽

F. Schulze ◽

...

Keyword(s):

Histamine Release ◽

Receptor Antagonist ◽

H2 Receptor Antagonist ◽

Antagonist Activity ◽

H2 Receptor ◽

Life Threatening ◽

Anaphylactoid Reactions

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H2-receptor antagonist activity of N-methylthiourea, N-cyano-N′-methylguanidine, N-cyanoamidine, N-carbamoylamidine and N-sulfamoylamidine 5-substituted thiazole derivatives on guinea-pig atria

Agents and Actions ◽

10.1007/bf02222237 ◽

1989 ◽

Vol 27 (1-2) ◽

pp. 195-197 ◽

Cited By ~ 1

Author(s):

E. Barocelli ◽

M. Chiavarini ◽

G. Morini ◽

P. V. Plazzi ◽

T. Vitali ◽

...

Keyword(s):

Guinea Pig ◽

Receptor Antagonist ◽

Thiazole Derivatives ◽

H2 Receptor Antagonist ◽

Antagonist Activity ◽

H2 Receptor ◽

Guinea Pig Atria

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Synthesis and Histamine H2-Receptor Antagonist Activity of 4-(1-Pyrazolyl)butanamides, Guanidinopyrazoles, and Related Compounds

Archiv der Pharmazie ◽

10.1002/ardp.19953280411 ◽

1995 ◽

Vol 328 (4) ◽

pp. 349-358 ◽

Cited By ~ 5

Author(s):

Armin Buschauer ◽

Rainer Mohr ◽

Walter Schunack

Keyword(s):

Receptor Antagonist ◽

H2 Receptor Antagonist ◽

Antagonist Activity ◽

Histamine H2 Receptor ◽

H2 Receptor ◽

Related Compounds ◽

Histamine H2 Receptor Antagonist

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ChemInform Abstract: Synthesis and Histamine H2-Receptor Antagonist Activity of 4-(1- Pyrazolyl)butanamides, Guanidinopyrazoles, and Related Compounds.

ChemInform ◽

10.1002/chin.199536146 ◽

2010 ◽

Vol 26 (36) ◽

pp. no-no

Author(s):

A. BUSCHAUER ◽

R. MOHR ◽

W. SCHUNACK

Keyword(s):

Receptor Antagonist ◽

H2 Receptor Antagonist ◽

Antagonist Activity ◽

Histamine H2 Receptor ◽

H2 Receptor ◽

Related Compounds ◽

Histamine H2 Receptor Antagonist

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ChemInform Abstract: Synthesis and Combined Histamine H1- and H2-Receptor Antagonist Activity of Mepyramine, Pheniramine, and Cyclizine Derivatives with Cyanoguanidine, Urea, and Nitroethenediamine Groups.

ChemInform ◽

10.1002/chin.199448157 ◽

2010 ◽

Vol 25 (48) ◽

pp. no-no

Author(s):

F. R. SCHULZE ◽

R. A. ALISCH ◽

A. BUSCHAUER ◽

W. SCHUNACK

Keyword(s):

Receptor Antagonist ◽

H2 Receptor Antagonist ◽

Antagonist Activity ◽

H2 Receptor

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The novel histamine H2 receptor antagonist FRG-8813 prevents delay of wound repair induced by hydrogen peroxide in a rabbit gastric epithelial cell system

Journal of Gastroenterology and Hepatology ◽

10.1046/j.1440-1746.1998.01735.x ◽

1998 ◽

Vol 13 (11-s4) ◽

pp. S209-S213

Author(s):

NOBUHIRO SATO ◽

SUMIO WATANABE ◽

XIAN-EN WANG ◽

TARO OSADA ◽

HIROSHI TANAKA ◽

...

Keyword(s):

Hydrogen Peroxide ◽

Epithelial Cell ◽

Receptor Antagonist ◽

Wound Repair ◽

Cell System ◽

The Novel ◽

H2 Receptor Antagonist ◽

Histamine H2 Receptor ◽

H2 Receptor ◽

Histamine H2 Receptor Antagonist

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Unique Profile of Lafutidine, A Novel Histamine H2-Receptor Antagonist - Mucosal Protection Throughout Gastrointestinal Tract Mediated by Capsaicin-Sensitive Afferent Neurons -

Drug Design Reviews - Online ◽

10.2174/1567269043480681 ◽

2004 ◽

Vol 1 (2) ◽

pp. 133-144 ◽

Cited By ~ 4

Author(s):

Sadayoshi Onodera ◽

Kayoko Nishida ◽

Koji Takeuchi

Keyword(s):

Gastrointestinal Tract ◽

Receptor Antagonist ◽

Mucosal Protection ◽

Afferent Neurons ◽

H2 Receptor Antagonist ◽

Histamine H2 Receptor ◽

H2 Receptor ◽

Histamine H2 Receptor Antagonist

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ChemInform Abstract: THE STRUCTURE OF CIMETIDINE (N′-CYANO-N-METHYL-N′-(2-((5-METHYL-1H-IMIDAZOL-4-YL)METHYLTHIO)ETHYL)GUANIDINE), A HISTAMINE H2-RECEPTOR ANTAGONIST

Chemischer Informationsdienst ◽

10.1002/chin.197845071 ◽

1978 ◽

Vol 9 (45) ◽

Author(s):

E. HAEDICKE ◽

F. FRICKEL ◽

A. FRANKE

Keyword(s):

Receptor Antagonist ◽

H2 Receptor Antagonist ◽

Histamine H2 Receptor ◽

H2 Receptor ◽

Histamine H2 Receptor Antagonist

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The metabolism in animals and man of oxmetidine—A new histamine H2-receptor antagonist

Xenobiotica ◽

10.3109/00498258409151439 ◽

1984 ◽

Vol 14 (7) ◽

pp. 509-514 ◽

Cited By ~ 1

Author(s):

P. J. Cox ◽

W. M. H. Heijbroek ◽

D. C. Taylor ◽

P. J. Wood ◽

P. R. Cresswell ◽

...

Keyword(s):

Receptor Antagonist ◽

H2 Receptor Antagonist ◽

Histamine H2 Receptor ◽

H2 Receptor ◽

Histamine H2 Receptor Antagonist

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