scholarly journals Elaboration of Stable and Antibody Functionalized Positively Charged Colloids by Polyelectrolyte Complexation between Chitosan and Hyaluronic Acid

Molecules ◽  
2013 ◽  
Vol 18 (7) ◽  
pp. 8563-8578 ◽  
Author(s):  
Ramona Polexe ◽  
Thierry Delair
Keyword(s):  
Hyaluronic Acid ◽  
Charged Colloids ◽  
Polyelectrolyte Complexation ◽  
Positively Charged

Synthetic imogolite: properties, synthesis and possible applications

Clay Minerals ◽  
1983 ◽  
Vol 18 (4) ◽  
pp. 459-472 ◽  
Author(s):  
V. C. Farmer ◽  
M. J. Adams ◽  
A. R. Fraser ◽  
F. Palmieri
Keyword(s):  
Mechanical Stability ◽  
Surface Acidity ◽  
Outer Diameter ◽  
Charged Colloids ◽  
Inner Surface ◽  
Forming Characteristics ◽  
Inner Diameter ◽  
Anionic Detergents ◽  
Positively Charged ◽  
Long Chain

AbstractThe unique properties of imogolite are closely related to its structure, which is a tube of 23–27 Å outer diameter and ∼10 Å inner diameter, with an AIOH outer surface and SiOH inner surface. Acid dispersions contain the long, positively-charged tubes as isolated units or small bundles, which form bulky gels in alkali, and flocculate with negatively-charged colloids, polyvalent anions, and long-chain anionic detergents. Sorption properties are associated with the 10 Å intra-tube pores and with inter-tube channels of variable dimensions. Surface acidity is less than that of layer-silicate clays. The chemical and mechanical stability, biological activity, film- and fibre-forming characteristics, and conditions of synthesis are reviewed, on the basis of both new and published findings. Areas of potential application are indicated.

scholarly journals Tuning the order of colloidal monolayers: assembly of heterogeneously charged colloids close to a patterned substrate

Soft Matter ◽  
2018 ◽  
Vol 14 (40) ◽  
pp. 8119-8136 ◽  
Author(s):  
Emanuele Locatelli ◽  
Emanuela Bianchi
Keyword(s):  
Patterned Substrate ◽  
Patterned Surface ◽  
Polar Caps ◽  
Charged Colloids ◽  
Positively Charged

We study the behavior of negatively charged colloids with two positively charged polar caps close to a planar patterned surface.

scholarly journals Hyaluronic Acid Inhibits Polycation Induced Cellular Responses

1994 ◽  
Vol 3 (4) ◽  
pp. 287-289 ◽  
Author(s):  
A. lalenti ◽  
A. lanaro ◽  
G. Brignola ◽  
P. Marotta ◽  
M. Di Rosa
Keyword(s):  
Hyaluronic Acid ◽  
Rabbit Aorta ◽  
Target Cells ◽  
Anionic Sites ◽  
Nitric Oxide Formation ◽  
Paw Oedema ◽  
Charged Macromolecules ◽  
Rat Paw ◽  
Rat Paw Oedema ◽  
Positively Charged

Positively charged macromolecules cause a variety of pathological events through their electrostatic interaction with anionic sites present on the membrane of target cells. In the present study we have investigated the effect of hyaluronic acid, a negatively charged molecule, on rat paw oedema induced by poly-L-lysine as well as on histamine release from rat mast cells and nitric oxide formation from rabbit aorta, both induced by this polycation. The results indicate that hyaluronic acid is able to suppress these poly-L-lysine induced effects with a mechanism which possibly depends on its negative charges which may balance the effects of positively charged polycations.

Formation and Properties of Positively Charged Colloids Based on Polyelectrolyte Complexes of Biopolymers

Langmuir ◽  
2004 ◽  
Vol 20 (18) ◽  
pp. 7766-7778 ◽  
Author(s):  
Christophe Schatz ◽  
Jean-Michel Lucas ◽  
Christophe Viton ◽  
Alain Domard ◽  
Christian Pichot ◽  
...  
Keyword(s):  
Polyelectrolyte Complexes ◽  
Charged Colloids ◽  
Positively Charged

scholarly journals Highly stretchable hydrogels from complex coacervation of natural polyelectrolytes

Soft Matter ◽  
2017 ◽  
Vol 13 (37) ◽  
pp. 6594-6605 ◽  
Author(s):  
Gautier Lalevée ◽  
Laurent David ◽  
Alexandra Montembault ◽  
Kevin Blanchard ◽  
John Meadows ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Complex Coacervation ◽  
Polyelectrolyte Complexation ◽  
Highly Stretchable

Polyelectrolyte complexation between chitosan and hyaluronic acid at pH between 2 and 3 leads to highly stretchable hydrogels.

Microscopics of Complexation between Long DNA Molecules and Positively Charged Colloids

2002 ◽  
Vol 89 (8) ◽  
Author(s):  
K. Keren ◽  
Y. Soen ◽  
G. Ben Yoseph ◽  
R. Gilad ◽  
E. Braun ◽  
...  
Keyword(s):  
Dna Molecules ◽  
Charged Colloids ◽  
Positively Charged

scholarly journals Selective binding of zinc ions to heparin rather than to other glycosaminoglycans

1981 ◽  
Vol 193 (2) ◽  
pp. 407-410 ◽  
Author(s):  
R F Parrish ◽  
W R Fair
Keyword(s):  
Hyaluronic Acid ◽  
Binding Affinity ◽  
Electrostatic Interactions ◽  
Gel Filtration ◽  
Zinc Ions ◽  
Dermatan Sulphate ◽  
Selective Binding ◽  
Relative Binding Affinity ◽  
Relative Binding ◽  
Positively Charged

The relative binding affinity of Zn2+ to several glycosaminoglycans was determined by gel-filtration chromatography. Binding was observed only between Zn2+ and heparin. No binding was observed between Zn2+ and chondroitin 4-sulphate, chondroitin 6-sulphate, dermatan sulphate of hyaluronic acid. All of the glycosaminoglycans contained carboxy groups, but only heparin bound Zn2+. This observation suggests that, contrary to a previously proposed hypothesis, simple electrostatic interactions between the negatively charged carboxy groups of the glycosaminoglycans and the positively charged Zn2+ cannot explain the observed binding.

scholarly journals A combinational chemo-immune therapy using an enzyme-sensitive nanoplatform for dual-drug delivery to specific sites by cascade targeting

2021 ◽  
Vol 7 (6) ◽  
pp. eaba0776 ◽  
Author(s):  
Yanmei He ◽  
Lei Lei ◽  
Jun Cao ◽  
Xiaotong Yang ◽  
Shengsheng Cai ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Targeted Delivery ◽  
Immune Therapy ◽  
Endosomal Escape ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles ◽  
Mitochondria Targeting ◽  
Positively Charged ◽  
Dual Drug

Nanoparticle-based drug delivery faces challenges from the imprecise targeted delivery and the low bioavailability of drugs due to complex biological barriers. Here, we designed cascade-targeting, dual drug–loaded, core-shell nanoparticles (DLTPT) consisting of CD44-targeting hyaluronic acid shells decorated with doxorubicin (HA-DOX) and mitochondria-targeting triphenylphosphonium derivative nanoparticle cores loaded with lonidamine (LND) dimers (LTPT). DLTPT displayed prolonged blood circulation time and efficiently accumulated at the tumor site due to the tumor-homing effect and negatively charged hyaluronic acid. Subsequently, the HA-DOX shell was degraded by extracellular hyaluronidase, resulting in decreased particle size and negative-to-positive charge reversal, which would increase tumor penetration and internalization. The degradation of HA-DOX further accelerated the release of DOX and exposed the positively charged LTPT core for rapid endosomal escape and mitochondria-targeted delivery of LND. Notably, when DLTPT was used in combination with anti–PD-L1, the tumor growth was inhibited, which induced immune response against tumor metastasis.

scholarly journals Microencapsulation of Lactobacillus casei in chitosan-Ca-alginate microparticles using spray-drying method

2012 ◽  
Vol 31 (1) ◽  
pp. 115 ◽  
Author(s):  
Tanja Petreska Ivanovska ◽  
Lidija Petruševska-Tozi ◽  
Margita Dabevska Kostoska ◽  
Nikola Geškovski ◽  
Anita Grozdanov ◽  
...  
Keyword(s):  
Spray Drying ◽  
Lactobacillus Casei ◽  
Freeze Drying ◽  
Drying Method ◽  
Effective Protection ◽  
Viable Cells ◽  
Therapeutic Value ◽  
Polyelectrolyte Complexation ◽  
Average Size ◽  
Positively Charged

In this study, the probiotic Lactobacillus casei was microencapsulated using the method of spray-drying combined with polyelectrolyte complexation of alginate, fructooligosaccharide and chitosan, and cross-linking with calcium chloride, followed by freeze-drying. Survival rate and physicochemical properties of the prepared microparticles were evaluated. In addition, viability of Lactobacillus casei in simulated gastric and intestinal juices was investigated. Positively charged microparticles with average size of 11.08±1.1 μm and high cell viability of 10.98±0.11 log cfu/g were prepared. The synbiotic microparticles were stable during exposure to simulated gastric and intestinal juices, while release of viable cells above the therapeutic value (8.31±0.14 log cfu/g) in the simulated colonic pH was observed.The presented method for microencapsulation of synbiotics shows potential for effective protection of viable probiotic cells during exposure to harsh environmental conditions.

scholarly journals Endosomal pH-Responsive Fe-Based Hyaluronate Nanoparticles for Doxorubicin Delivery

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3547
Author(s):  
Yangmun Bae ◽  
Yoonyoung Kim ◽  
Eun Seong Lee
Keyword(s):  
Hyaluronic Acid ◽  
Tumor Cells ◽  
Tumor Targeting ◽  
Drug Carriers ◽  
Acidic Environment ◽  
Ph Responsive ◽  
Ferrous Chloride ◽  
Endosomal Ph ◽  
Dimethylmaleic Anhydride ◽  
Positively Charged

In this study, we report pH-responsive metal-based biopolymer nanoparticles (NPs) for tumor-specific chemotherapy. Here, aminated hyaluronic acid (aHA) coupled with 2,3-dimethylmaleic anhydride (DMA, as a pH-responsive moiety) (aHA-DMA) was electrostatically complexed with ferrous chloride tetrahydrate (FeCl2/4H2O, as a chelating metal) and doxorubicin (DOX, as an antitumor drug model), producing DOX-loaded Fe-based hyaluronate nanoparticles (DOX@aHA-DMA/Fe NPs). Importantly, the DOX@aHA-DMA/Fe NPs improved tumor cellular uptake due to HA-mediated endocytosis for tumor cells overexpressing CD44 receptors. As a result, the average fluorescent DOX intensity observed in MDA-MB-231 cells (with CD44 receptors) was ~7.9 × 102 (DOX@HA/Fe NPs, without DMA), ~8.1 × 102 ([email protected]/Fe NPs), and ~9.3 × 102 ([email protected]/Fe NPs). Furthermore, the DOX@aHA-DMA/Fe NPs were destabilized due to ionic repulsion between Fe2+ and DMA-detached aHA (i.e., positively charged free aHA) in the acidic environment of tumor cells. This event accelerated the release of DOX from the destabilized NPs. Our results suggest that these NPs can be promising tumor-targeting drug carriers responding to acidic endosomal pH.

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