scholarly journals Design, Practical Synthesis, and Biological Evaluation of Novel 6-(Pyrazolylmethyl)-4-quinoline-3-carboxylic Acid Derivatives as HIV-1 Integrase Inhibitors

Molecules ◽  
2012 ◽  
Vol 17 (9) ◽  
pp. 10652-10666 ◽  
Author(s):  
Liming Hu ◽  
Song Yan ◽  
Zaigang Luo ◽  
Xiao Han ◽  
Yujie Wang ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Biological Evaluation ◽  
Integrase Inhibitors ◽  
Practical Synthesis ◽  
Synthesis And Biological Evaluation ◽  
Hiv 1

scholarly journals Design, Synthesis, and Biological Evaluation of 1,2-Dihydroisoquinolines as HIV-1 Integrase Inhibitors

2015 ◽  
Vol 6 (10) ◽  
pp. 1065-1070 ◽  
Author(s):  
Vibha Tandon ◽  
Urvashi ◽  
Pooja Yadav ◽  
Souvik Sur ◽  
Sheenu Abbat ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Integrase Inhibitors ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation ◽  
Hiv 1

Synthesis and biological evaluation of HQCAs with aryl or benzyl substituents on N-1 position as potential HIV-1 integrase inhibitors

2011 ◽  
Vol 19 (18) ◽  
pp. 5553-5558 ◽  
Author(s):  
Qiu-Qin He ◽  
Xuan Zhang ◽  
Hai-Qiu Wu ◽  
Shuang-Xi Gu ◽  
Xiao-Dong Ma ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Integrase Inhibitors ◽  
Synthesis And Biological Evaluation ◽  
Hiv 1

Synthesis and Biological Evaluation of Quinolone Acid Derivatives Having Polyhydroxylated Aromatics as HIV-1 Integrase Inhibitions

2013 ◽  
Vol 634-638 ◽  
pp. 1116-1119 ◽  
Author(s):  
Xue Mei Xu ◽  
Zai Gang Luo ◽  
Kuai He ◽  
Ming Yang Zhang
Keyword(s):  
Transfer Process ◽  
Biological Evaluation ◽  
Strand Transfer ◽  
Integrase Inhibitors ◽  
Chemical Library ◽  
Aromatic Substituent ◽  
Small Chemical ◽  
Synthesis And Biological Evaluation ◽  
Hiv 1

A small chemical library of quinolone acid derivatives were synthesized as potential HIV-1 integrase inhibitors and evaluated their inhibition to the strand transfer process of HIV-1 integrase. Their structures were characterized by NMR, MS and HRMS. The result indicates that quinolone acid derivatives having 3,4,5-trihydroxylated aromatic substituent on the N-1 position of quinolone ring exhibit good inhibition with IC50 of 2.6 μM.

Synthesis and Biological Evaluation of Geminal Disulfones as HIV-1 Integrase Inhibitors

2005 ◽  
Vol 48 (14) ◽  
pp. 4526-4534 ◽  
Author(s):  
D. Christopher Meadows ◽  
Timothy B. Mathews ◽  
Thomas W. North ◽  
Michael J. Hadd ◽  
Chih Lin Kuo ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Integrase Inhibitors ◽  
Synthesis And Biological Evaluation ◽  
Hiv 1
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