scholarly journals Laminarin Induces Apoptosis of Human Colon Cancer LOVO Cells through a Mitochondrial Pathway

Molecules ◽  
2012 ◽  
Vol 17 (8) ◽  
pp. 9947-9960 ◽  
Author(s):  
Yu Bin Ji ◽  
Chen Feng Ji ◽  
He Zhang
Keyword(s):  
Colon Cancer ◽  
Human Colon ◽  
Mitochondrial Pathway ◽  
Human Colon Cancer ◽  
Lovo Cells

scholarly journals Laminarin-induced apoptosis in human colon cancer LoVo cells

2014 ◽  
Vol 7 (5) ◽  
pp. 1728-1732 ◽  
Author(s):  
CHEN-FENG JI ◽  
YU-BIN JI
Keyword(s):  
Colon Cancer ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Lovo Cells ◽  
Induced Apoptosis

scholarly journals LINC02418 promotes colon cancer progression by suppressing apoptosis via interaction with miR-34b-5p/BCL2 axis

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Jun Tian ◽  
Peng Cui ◽  
Yifei Li ◽  
Xuequan Yao ◽  
Xiaoyu Wu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Signaling Pathway ◽  
Cancer Progression ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Kaplan Meier ◽  
Lovo Cells ◽  
Colon Cancer Progression ◽  
Prediction Of Prognosis

Abstract Background LncRNAs act as functional regulators in tumor progression through interacting with various signaling pathways in multiple types of cancer. However, the effect of LINC02418 on colorectal cancer (CRC) progression and the underling mechanisms remain unclear. Methods LncRNA expression profile in CRC tissues was investigated by the TCGA database. The expressional level of LINC02418 in CRC patients was determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Kaplan–Meier analyses was used to investigate the correlation between LINC02418 and overall survival (OS) of CRC patients. Cell proliferative, migratory and invasive abilities were detected by CCK-8 assays, colony formation assays and trans-well assays in HCT116 and LoVo cells which were stably transduced with sh-LINC02418 or sh-NC. The binding between LINC02418 and miR-34b-5p, and the interaction between miR-34b-5p and BCL2 were determined by dual-luciferase assays. Western blot experiments were conducted to further explore the effect of miR-34b-5p on BCL2 signaling pathway. Rescue experiments were performed to uncover the role of LINC02418/miR-34b-5p/BCL2 axis in CRC progression. Results LINC02418 was upregulated in human colon cancer samples when compared with adjacent tissue, and its high expressional level correlated with poor prognosis of CRC patients. LINC02418 promoted cancer progression by enhancing tumor growth, cell mobility and invasiveness of colon cancer cells. Additionally, LINC02418 could physically bind to miR-34b-5p and subsequently affect BCL2 signaling pathway. Down-regulation of LINC02418 reduced cell proliferation, while transfection of miR-34b-5p inhibitor or BCL2 into LINC02418-silenced CRC cells significantly promoted CRC cells growth. Conclusions LINC02418 was upregulated in human CRC samples and could be used as the indicator for prediction of prognosis. LINC02418 acted as a tumor driver by negatively regulating cell apoptosis through LINC02418/miR-34b-5p/BCL2 axis in CRC.

UCP2-Related Mitochondrial Pathway Participates in Oroxylin A-Induced Apoptosis in Human Colon Cancer Cells

2015 ◽  
Vol 230 (5) ◽  
pp. 1054-1063 ◽  
Author(s):  
Chen Qiao ◽  
Libin Wei ◽  
Qinsheng Dai ◽  
Yuxin Zhou ◽  
Qian Yin ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Human Colon ◽  
Mitochondrial Pathway ◽  
Colon Cancer Cells ◽  
Oroxylin A ◽  
Human Colon Cancer ◽  
Induced Apoptosis ◽  
Human Colon Cancer Cells

scholarly journals Microparticles vs. Macroparticles as Curcumin Delivery Vehicles: Structural Studies and Cytotoxic Effect in Human Adenocarcinoma Cell Line (LoVo)

Molecules ◽  
2021 ◽  
Vol 26 (19) ◽  
pp. 6056
Author(s):  
Joanna Wezgowiec ◽  
Marta Tsirigotis-Maniecka ◽  
Jolanta Saczko ◽  
Mieszko Wieckiewicz ◽  
Kazimiera A. Wilk
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Anticancer Properties ◽  
Lovo Cells ◽  
Delivery Vehicles ◽  
Average Size ◽  
Human Colon Cancer Cells

This study aimed to characterize the hydrogel micro- and macro-particles designed to deliver curcumin to human colon cancer cells (LoVo). Six series of vehicles based on sodium alginate (micro- and macro-particles, uncoated, coated with chitosan or gelatin) were synthesized. The uncoated microparticles were fabricated using an emulsion-based technique and the uncoated macroparticles with an extrusion technique, with both coupled with ionotropic gelation. The surface morphology of the particles was examined with scanning electron microscopy and the average size was measured. The encapsulation efficiency, moisture content, and swelling index were calculated. The release of curcumin from the particles was studied in an experiment simulating the conditions of the stomach, intestine, and colon. To evaluate the anticancer properties of such targeted drug delivery systems, the cytotoxicity of both curcumin-loaded and unloaded carriers to human colon cancer cells was assessed. The microparticles encapsulated much less of the payload than the macroparticles and released their content in a more prolonged manner. The unloaded carriers were not cytotoxic to LoVo cells, while the curcumin-loaded vehicles impaired their viability—more significantly after incubation with microparticles compared to macroparticles. Gelatin-coated or uncoated microparticles were the most promising carriers but their potential anticancer activity requires further thorough investigation.

scholarly journals Role of Sphk1 in the proliferation and invasion of human colon cancer Lovo cells

2010 ◽  
Vol 18 (24) ◽  
pp. 2528
Author(s):  
Yue-Yuan Zhong ◽  
Jie-An Huang ◽  
Shi-Quan Liu ◽  
Meng-Bin Qin ◽  
Hui Jin
Keyword(s):  
Colon Cancer ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Lovo Cells ◽  
Proliferation And Invasion
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