scholarly journals Gastroprotection of Suaveolol, Isolated from Hyptis suaveolens, against Ethanol-Induced Gastric Lesions in Wistar Rats: Role of Prostaglandins, Nitric Oxide and Sulfhydryls

Molecules ◽  
2012 ◽  
Vol 17 (8) ◽  
pp. 8917-8927 ◽  
Author(s):  
Carlos Vera-Arzave ◽  
Leticia Cruz Antonio ◽  
Jesús Arrieta ◽  
Gerardo Cruz-Hernández ◽  
Antonio Magdiel Velázquez-Méndez ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Wistar Rats ◽  
Gastric Lesions ◽  
Hyptis Suaveolens

Gastroprotective effects of goniothalamin against ethanol and indomethacin-induced gastric lesions in rats: Role of prostaglandins, nitric oxide and sulfhydryl compounds

2014 ◽  
Vol 224 ◽  
pp. 206-212 ◽  
Author(s):  
Débora Barbosa Vendramini-Costa ◽  
Karin Maia Monteiro ◽  
Leilane Hespporte Iwamoto ◽  
Michelle Pedroza Jorge ◽  
Sirlene Valério Tinti ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Gastric Lesions ◽  
Sulfhydryl Compounds

scholarly journals Role of nitric oxide in the control of blood pressure in salt-loaded Wistar rats.

1996 ◽  
Vol 71 ◽  
pp. 320
Author(s):  
Norikazu Yamaguchi ◽  
Takeshi Fujii ◽  
Kazuko Fujimoto ◽  
Takeshi Suzuki ◽  
Koichiro Kawashima
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
Wistar Rats

scholarly journals Further evidence for the role of nitric oxide in maternal aggression: effects of L-NAME on maternal aggression towards female intruders in Wistar rats

2009 ◽  
pp. 591-598
Author(s):  
S Ankarali ◽  
HC Ankarali ◽  
C Marangoz
Keyword(s):  
Nitric Oxide ◽  
Methyl Ester ◽  
Aggressive Behavior ◽  
Wistar Rats ◽  
No Production ◽  
Maternal Aggression ◽  
Prairie Voles ◽  
Nos Inhibitor ◽  
Oxide Synthase

It has been shown that nitric oxide (NO) increases aggression in male mice, whereas it decreases aggression in lactating female mice and prairie voles. It is also known that aggression can be exhibited at different levels in rodent species, strain or subtypes. The aims of this study were to investigate the proportion of aggressiveness in Wistar rats, the effect of intraperitoneally administered nonspecific nitric oxide synthase (NOS) inhibitor L-NAME (NG-nitro L-arginine methyl ester) on maternal aggression towards female intruders, and whether these effects are due to NO production or not. Rats were given saline intraperitoneally on the postpartum Day 2 and aggression levels were recorded. The same rats were given 60 mg/kg L-NAME or D-NAME (NG -nitro D-arginine methyl ester) on the postpartum Day 3 and their effects on aggression levels were compared to saline. While L-NAME administration did not cause any differences in the total number of aggressive behavior, aggression duration and aggression intensity, it reduced the proportion of animals showing aggressive behavior. In addition, the latency of the first aggression was significantly increased by L-NAME. In the D-NAME group, however, no significant change was found. Our results have shown that L-NAME reduces maternal aggression towards female intruders in Wistar rats through inhibition of NO production. These results suggest that the role of NO in offensive and defensive maternal aggression shares neural mechanisms.

Gastroprotective activity of Pradosia huberi on experimentally induced gastric lesions in rodents: Role of endogenous sulphydryls and nitric oxide

2005 ◽  
Vol 101 (1-3) ◽  
pp. 61-67 ◽  
Author(s):  
Hélio Kushima ◽  
Clélia Akiko Hiruma-Lima ◽  
Maria Aparecida Santos ◽  
Elizabeth Viana ◽  
Márlia Coelho-Ferreira ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Gastric Lesions ◽  
Gastroprotective Activity ◽  
Experimentally Induced

Insulin sensitivity is mediated by the activation of the ACh/NO/cGMP pathway in rat liver

2004 ◽  
Vol 287 (3) ◽  
pp. G527-G532 ◽  
Author(s):  
Maria P. Guarino ◽  
Nina C. Correia ◽  
W. Wayne Lautt ◽  
M. Paula Macedo
Keyword(s):  
Nitric Oxide ◽  
Insulin Sensitivity ◽  
Muscarinic Receptors ◽  
Wistar Rats ◽  
No Donor ◽  
Parasympathetic Nerves ◽  
Cgmp Pathway ◽  
Male Wistar Rats ◽  
Oxide Synthase

The hepatic parasympathetic nerves and hepatic nitric oxide synthase (NOS) are involved in the secretion of a hepatic insulin sensitizing substance (HISS), which mediates peripheral insulin sensitivity. We tested whether binding of ACh to hepatic muscarinic receptors is an upstream event to the synthesis of nitric oxide (NO), which, along with the activation of hepatic guanylate cyclase (GC), permits HISS release. Male Wistar rats (8–9 wk) were anesthetized with pentobarbital sodium (65 mg/kg). Insulin sensitivity was assessed using a euglycemic clamp [the rapid insulin sensitivity test (RIST)]. HISS inhibition was induced by antagonism of muscarinic receptors (atropine, 3 mg/kg iv) or by blockade of NOS [ NG-nitro-l-arginine methyl ester (l-NAME), 1 mg/kg intraportally (ipv)]. After the blockade, HISS action was tentatively restored using a NO donor [3-morpholynosydnonimine (SIN-1), 5–10 mg/kg ipv] or ACh (2.5–5 μg·kg−1·min−1 ipv). SIN-1 (10 mg/kg) reversed the inhibition caused by atropine (RIST postatropine 137.7 ± 8.3 mg glucose/kg; reversed to 288.3 ± 15.5 mg glucose/kg, n = 6) and by l-NAME (RIST post-l-NAME 152.2 ± 21.3 mg glucose/kg; reversed to 321.7 ± 44.7 mg glucose/kg, n = 5). ACh did not reverse HISS inhibition induced by l-NAME. The role of GC in HISS release was assessed using 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ, 5 nmol/kg ipv), a GC inhibitor that decreased HISS action (control RIST 237.6 ± 18.6 mg glucose/kg; RIST post-ODQ 111.7 ± 6.2 mg glucose/kg, n = 5). We propose that hepatic parasympathetic nerves release ACh, leading to hepatic NO synthesis, which activates GC, triggering HISS action.

Effect of Mouriri pusa extracts on experimentally induced gastric lesions in rodents: Role of endogenous sulfhydryls compounds and nitric oxide in gastroprotection

2006 ◽  
Vol 107 (3) ◽  
pp. 431-441 ◽  
Author(s):  
Marcio Adriano Andreo ◽  
Kátia Verônica Rodríguez Ballesteros ◽  
Clélia Akiko Hiruma-Lima ◽  
Lúcia Regina Machado da Rocha ◽  
Alba Regina Monteiro Souza Brito ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Gastric Lesions ◽  
Experimentally Induced

scholarly journals Gastroprotective Effect of Juanislamin on Ethanol-Induced Gastric Lesions in Rats: Role of Prostaglandins, Nitric Oxide and Sulfhydryl Groups in the Mechanism of Action

Molecules ◽  
2020 ◽  
Vol 25 (9) ◽  
pp. 2246
Author(s):  
María Elena Sánchez-Mendoza ◽  
Yaraset López-Lorenzo ◽  
Leticia Cruz-Antonio ◽  
Arturo Cruz-Oseguera ◽  
Jazmín García-Machorro ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Mechanism Of Action ◽  
Gastrointestinal Disorder ◽  
Sulfhydryl Groups ◽  
Dependent Manner ◽  
Gastric Lesions ◽  
Reference Drug ◽  
Ulcer Disease ◽  
Gastroprotective Effect

Peptic ulcer disease, the most common gastrointestinal disorder, is currently treated with several types of drugs, but all have severe side effects. The aim of the present study was to evaluate the gastroprotective activity of juanislamin, isolated from Calea urticifolia, in a rat model of ethanol-induced gastric lesions. Thirty minutes after orally administering a given dose of juanislamin (from 1 to 30 mg/kg) or carbenoxolone (the reference drug, at 1–100 mg/kg) to rats, 1 mL of ethanol was applied, and the animals were sacrificed 2 h later. The stomachs were removed and opened to measure the total area of lesions in each. To examine the possible participation of prostaglandins, nitric oxide and/or sulfhydryl groups in the mechanism of action of juanislamin, the rats received indomethacin, NG-Nitro-l-arginine methyl ester hydrochloride (l-NAME) or N-ethylmaleimide pretreatment, respectively, before being given juanislamin and undergoing the rest of the methodology. Juanislamin inhibited gastric lesions produced by ethanol in a non-dose-dependent manner, showing the maximum gastroprotective effect (100%) at 10 mg/kg. The activity of juanislamin was not modified by pretreatment with indomethacin, l-NAME or N-ethylmaleimide. In conclusion, juanislamin protected the gastric mucosa from ethanol-induced damage, and its mechanism of action apparently does not involve prostaglandins, nitric oxide or sulfhydryl groups.

Role of prostaglandins, nitric oxide (NO) and cytokines in gastroprotection by PPARgamma agonist against ethanol and stress-induced gastric lesions

2003 ◽  
Vol 124 (4) ◽  
pp. A498
Author(s):  
Slawomir Kwiecien ◽  
Thomas Brzozowski ◽  
Peter C. Konturek ◽  
Agata Ptak ◽  
Stanislaw J. Konturek ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Gastric Lesions
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