scholarly journals Synthesis of Main-Chain Chiral Quaternary Ammonium Polymers for Asymmetric Catalysis Using Quaternization Polymerization

Molecules ◽  
2012 ◽  
Vol 17 (6) ◽  
pp. 7569-7583 ◽  
Author(s):  
Naoki Haraguchi ◽  
Parbhej Ahamed ◽  
Md. Masud Parvez ◽  
Shinichi Itsuno
Keyword(s):  
Asymmetric Catalysis ◽  
Quaternary Ammonium ◽  
Main Chain

Antibacterial activity of cationic polymers: side-chain or main-chain type?

2018 ◽  
Vol 9 (37) ◽  
pp. 4611-4616 ◽  
Author(s):  
Jiangna Guo ◽  
Jing Qin ◽  
Yongyuan Ren ◽  
Bin Wang ◽  
Hengqing Cui ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Small Molecule ◽  
Quaternary Ammonium ◽  
Main Chain ◽  
Side Chain ◽  
Cationic Polymers ◽  
Cationic Compounds ◽  
Chain Type

Imidazolium (Im), quaternary ammonium (Qa), and 1,4-diazabicyclo[2.2.2]octane-1,4-diium (DABCO-diium) cation-based small molecule cationic compounds and their corresponding side-chain/main-chain cationic polymers were synthesized.

Correction to Main-Chain Optically Active Riboflavin Polymer for Asymmetric Catalysis and Its Vapochromic Behavior

2012 ◽  
Vol 134 (43) ◽  
pp. 18150-18150 ◽  
Author(s):  
Hiroki Iida ◽  
Soichiro Iwahana ◽  
Tomohisa Mizoguchi ◽  
Eiji Yashima
Keyword(s):  
Asymmetric Catalysis ◽  
Main Chain ◽  
Optically Active ◽  
Vapochromic Behavior

Molecular design of chiral quaternary ammonium polymers for asymmetric catalysis applications

2012 ◽  
Vol 10 (14) ◽  
pp. 2870 ◽  
Author(s):  
Md. Masud Parvez ◽  
Naoki Haraguchi ◽  
Shinichi Itsuno
Keyword(s):  
Asymmetric Catalysis ◽  
Quaternary Ammonium ◽  
Molecular Design

scholarly journals Design, Synthesis, Antibacterial, and Antitumor Activity of Linear Polyisocyanide Quaternary Ammonium Salts with Different Structures and Chain Lengths

Molecules ◽  
2021 ◽  
Vol 26 (18) ◽  
pp. 5686
Author(s):  
Hongguang Zhang ◽  
Lijia Liu ◽  
Peng Hou ◽  
Jun Liu ◽  
Shuang Fu
Keyword(s):  
Antibacterial Activity ◽  
Quaternary Ammonium ◽  
Main Chain ◽  
Quaternary Ammonium Salts ◽  
Polymer Materials ◽  
Ammonium Salts ◽  
Organic Polymer ◽  
Side Chain ◽  
E Coli ◽  
Chain Lengths

The development of organic polymer materials for disinfection and sterilization is thought of as one of the most promising avenues to solve the growth and spread of harmful microorganisms. Here, a series of linear polyisocyanide quaternary ammonium salts (L-PQASs) with different structures and chain lengths were designed and synthesized by polymerization of phenyl isocyanide monomer containing a 4-chloro-1-butyl side chain followed by quaternary amination salinization. The resultant compounds were characterized by 1H NMR and FT-IR. The antibacterial activity of L-PQASs with different structures and chain lengths against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) was evaluated by determining the minimum inhibitory concentrations (MICs). The L-POcQAS-M50 has the strongest antimicrobial activity with MICs of 27 μg/mL against E. coli and 32 μg/mL against S. aureus. When the L-PQASs had the same polymerization degree, the order of the antibacterial activity of the L-PQASs was L-POcQAS-Mn > L-PBuQAS-Mn > L-PBnQAS-Mn > L-PDBQAS-Mn (linear, polyisocyanide quaternary ammonium salt, monomer, n = 50,100). However, when L-PQASs had the same side chain, the antibacterial activity reduced with the increase of the molecular weight of the main chain. These results demonstrated that the antibacterial activity of L-PQASs was dependent on the structure of the main chain and the length of the side chain. In addition, we also found that the L-POcQAS-M50 had a significant killing effect on MK-28 gastric cancer cells.

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