scholarly journals A Support Vector Machine Classification Model for Benzo[c]phenathridine Analogues with Topoisomerase-I Inhibitory Activity

Molecules ◽  
2012 ◽  
Vol 17 (4) ◽  
pp. 4560-4582 ◽  
Author(s):  
Khac-Minh Thai ◽  
Thuy-Quyen Nguyen ◽  
Trieu-Du Ngo ◽  
Thanh-Dao Tran ◽  
Thi-Ngoc-Phuong Huynh
Keyword(s):  
Support Vector Machine ◽  
Inhibitory Activity ◽  
Topoisomerase I ◽  
Classification Model ◽  
Support Vector ◽  
Support Vector Machine Classification

Predicting Hub Genes of Glioblastomas Based on Support Vector Machine Combined with CFS algorithms

2020 ◽  
Vol 15 ◽  
Author(s):  
Chun Qiu ◽  
Sai Li ◽  
Shenghui Yang ◽  
Lin Wang ◽  
Aihui Zeng ◽  
...  
Keyword(s):  
Support Vector Machine ◽  
Expression Profiles ◽  
Independent Set ◽  
Classification Model ◽  
Support Vector ◽  
Feature Subset ◽  
Hub Genes ◽  
Effective Prevention ◽  
Key Genes ◽  
Control Samples

Aim: To search the genes related to the mechanisms of the occurrence of glioma and to try to build a prediction model for glioblastomas. Background: The morbidity and mortality of glioblastomas are very high, which seriously endangers human health. At present, the goals of many investigations on gliomas are mainly to understand the cause and mechanism of these tumors at the molecular level and to explore clinical diagnosis and treatment methods. However, there is no effective early diagnosis method for this disease, and there are no effective prevention, diagnosis or treatment measures. Methods: First, the gene expression profiles derived from GEO were downloaded. Then, differentially expressed genes (DEGs) in the disease samples and the control samples were identified. After that, GO and KEGG enrichment analyses of DEGs were performed by DAVID. Furthermore, the correlation-based feature subset (CFS) method was applied to the selection of key DEGs. In addition, the classification model between the glioblastoma samples and the controls was built by an Support Vector Machine (SVM) based on selected key genes. Results and Discussion: Thirty-six DEGs, including 17 upregulated and 19 downregulated genes, were selected as the feature genes to build the classification model between the glioma samples and the control samples by the CFS method. The accuracy of the classification model by using a 10-fold cross-validation test and independent set test was 76.25% and 70.3%, respectively. In addition, PPP2R2B and CYBB can also be found in the top 5 hub genes screened by the protein– protein interaction (PPI) network. Conclusions: This study indicated that the CFS method is a useful tool to identify key genes in glioblastomas. In addition, we also predicted that genes such as PPP2R2B and CYBB might be potential biomarkers for the diagnosis of glioblastomas.

scholarly journals KLASIFIKASI TEKS SOSIAL MEDIA TWITTER MENGGUNAKAN SUPPORT VECTOR MACHINE (Studi Kasus Penusukan Wiranto)

2019 ◽  
Vol 2 (2) ◽  
pp. 43
Author(s):  
Lalu Mutawalli ◽  
Mohammad Taufan Asri Zaen ◽  
Wire Bagye
Keyword(s):  
Social Media ◽  
Support Vector Machine ◽  
Big Data ◽  
Mass Communication ◽  
Confusion Matrix ◽  
Classification Model ◽  
Support Vector ◽  
Large Set ◽  
Appearance Time ◽  
Data Production

In the era of technological disruption of mass communication, social media became a reference in absorbing public opinion. The digitalization of data is very rapidly produced by social media users because it is an attempt to represent the feelings of the audience. Data production in question is the user posts the status and comments on social media. Data production by the public in social media raises a very large set of data or can be referred to as big data. Big data is a collection of data sets in very large numbers, complex, has a relatively fast appearance time, so that makes it difficult to handle. Analysis of big data with data mining methods to get knowledge patterns in it. This study analyzes the sentiments of netizens on Twitter social media on Mr. Wiranto stabbing case. The results of the sentiment analysis showed 41% gave positive comments, 29% commented neutrally, and 29% commented negatively on events. Besides, modeling of the data is carried out using a support vector machine algorithm to create a system capable of classifying positive, neutral, and negative connotations. The classification model that has been made is then tested using the confusion matrix technique with each result is a precision value of 83%, a recall value of 80%, and finally, as much as 80% obtained in testing the accuracy.

scholarly journals Analisis Sentimen Twitter untuk Teks Berbahasa Indonesia dengan Maximum Entropy dan Support Vector Machine

2014 ◽  
Vol 8 (1) ◽  
pp. 91 ◽  
Author(s):  
Noviah Dwi Putranti ◽  
Edi Winarko
Keyword(s):  
Support Vector Machine ◽  
Maximum Entropy ◽  
Social Networking Site ◽  
Training Data ◽  
Classification Model ◽  
Support Vector ◽  
Public Sentiment ◽  
Pos Tagger ◽  
Negative Sentiment ◽  
Bahasa Indonesia

AbstrakAnalisis sentimen dalam penelitian ini merupakan proses klasifikasi dokumen tekstual ke dalam dua kelas, yaitu kelas sentimen positif dan negatif.  Data opini diperoleh dari jejaring sosial Twitter berdasarkan query dalam Bahasa Indonesia. Penelitian ini bertujuan untuk menentukan sentimen publik terhadap objek tertentu yang disampaikan di Twitter dalam bahasa Indonesia, sehingga membantu usaha untuk melakukan riset pasar atas opini publik. Data yang sudah terkumpul dilakukan proses preprocessing dan POS tagger untuk menghasilkan model klasifikasi melalui proses pelatihan. Teknik pengumpulan kata yang memiliki sentimen dilakukan dengan pendekatan berdasarkan kamus, yang dihasilkan dalam penelitian ini berjumlah 18.069 kata. Algoritma Maximum Entropy digunakan untuk POS tagger dan algoritma yang digunakan untuk membangun model klasifikasi atas data pelatihan dalam penelitian ini adalah Support Vector Machine. Fitur yang digunakan adalah unigram dengan fitur pembobotan TFIDF. Implementasi klasifikasi diperoleh akurasi 86,81 %  pada pengujian 7 fold cross validation untuk tipe kernel Sigmoid. Pelabelan kelas secara manual dengan POS tagger menghasilkan akurasi 81,67%.  Kata kunci—analisis sentimen, klasifikasi, maximum entropy POS tagger, support vector machine, twitter.  AbstractSentiment analysis in this research classified textual documents into two classes, positive and negative sentiment. Opinion data obtained a query from social networking site Twitter of Indonesian tweet. This research uses  Indonesian tweets. This study aims to determine public sentiment toward a particular object presented in Twitter businesses conduct market. Collected data then prepocessed to help POS tagged to generate classification models through the training process. Sentiment word collection has done the dictionary based approach, which is generated in this study consists 18.069 words. Maximum Entropy algorithm is used for POS tagger and the algorithms used to build the classification model on the training data is Support Vector Machine. The unigram features used are the features of TFIDF weighting.Classification implementation 86,81 % accuration at examination of 7 validation cross fold for the type of kernel of Sigmoid. Class labeling manually with POS tagger yield accuration 81,67 %. Keywords—sentiment analysis, classification, maximum entropy POS tagger, support vector machine, twitter.

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