scholarly journals Repeated Dose 28-Days Oral Toxicity Study of Carica papaya L. Leaf Extract in Sprague Dawley Rats

Molecules ◽  
2012 ◽  
Vol 17 (4) ◽  
pp. 4326-4342 ◽  
Author(s):  
Adlin Afzan ◽  
Noor Rain Abdullah ◽  
Siti Zaleha Halim ◽  
Badrul Amini Rashid ◽  
Raja Hazlini Raja Semail ◽  
...  
Keyword(s):  
Leaf Extract ◽  
Carica Papaya ◽  
Toxicity Study ◽  
Repeated Dose ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Sprague Dawley Rats

4-Week repeated dose oral toxicity study of N-ethyl-2-pyrrolidone in Sprague Dawley rats

2016 ◽  
Vol 81 ◽  
pp. 275-283 ◽  
Author(s):  
A.M. Saillenfait ◽  
F. Marquet ◽  
J.P. Sabaté ◽  
D. Ndiaye ◽  
A.M. Lambert-Xolin
Keyword(s):  
Toxicity Study ◽  
Repeated Dose ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Sprague Dawley Rats ◽  
Dose Oral

Physicochemical analysis and repeated-dose 90-days oral toxicity study of nanocalcium carbonate in Sprague-Dawley rats

2014 ◽  
Vol 9 (5) ◽  
pp. 603-612 ◽  
Author(s):  
Jae Hyuck Sung ◽  
Soo Jin Park ◽  
Min Sook Jeong ◽  
Kyung Seuk Song ◽  
Kyu Sup Ahn ◽  
...  
Keyword(s):  
Physicochemical Analysis ◽  
Toxicity Study ◽  
Repeated Dose ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Sprague Dawley Rats

scholarly journals Single- and repeated-dose 28-day oral toxicity study of MDM hydantoin in Sprague–Dawley rats

2020 ◽  
Author(s):  
Hansol Won ◽  
Jin Hee Lee ◽  
Ji-Hyun Seok ◽  
Kikyung Jung ◽  
Jun-Young Yang ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Repeated Dose ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Sprague Dawley Rats

scholarly journals A 4-Week Repeated-Dose Oral Toxicity Study of Bojungikgi-Tang in Crl:CD Sprague Dawley Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Sae-Rom Yoo ◽  
Hyekyung Ha ◽  
Mee-Young Lee ◽  
Hyeun-Kyoo Shin ◽  
Su-Cheol Han ◽  
...  
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Serum Biochemistry ◽  
Toxicity Study ◽  
Repeated Dose ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Organ Weights ◽  
Sprague Dawley Rats ◽  
Dose Oral

Traditional herbal medicines have been used for centuries in Asian countries. However, recent studies have led to increasing concerns about the safety and toxicity of herbal prescriptions. Bojungikgi-tang (BJIGT), a herbal decoction, has been used in Korea to improve physical strength. To establish the safety information, BJIGT water extract was evaluated in a 4-week repeated-dose oral toxicity test in Crl:CD Sprague Dawley rats. BJIGT was orally administered in daily doses of 0, 500, 1000, and 2000 mg/kg/day for 4 weeks via oral gavage in male and female rats. We examined the mortality, clinical signs, body weight change, food intake, organ weights, hematology, serum biochemistry, and urinalysis parameters. No significant changes were observed in mortality, clinical sings, body weight, food intake, organ weights, hematology, serum biochemistry, and urinalysis parameters between the control group and the BJIGT-treated groups in the rats of both sexes. The results indicate that BJIGT did not induce toxic effects at a dose level up to 2000 mg/kg in rats. Thus, this concentration is considered the nonobservable effect dose in rats and is appropriate for a 13-week subchronic toxicity study.

A 14-day Repeated Dose Oral Toxicity Study of HT042 in Sprague-Dawley Rats

2017 ◽  
Vol 32 (1) ◽  
pp. 63-68
Author(s):  
Jungbin Song ◽  
Donghun Lee ◽  
Young-Sik Kim ◽  
Seunggyeong Lee ◽  
Jin-Sook Bae ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Repeated Dose ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Sprague Dawley Rats ◽  
Dose Oral

scholarly journals A 4-week Repeated dose Oral Toxicity Study of Mecasin in Sprague-Dawley Rats to Determine the Appropriate Doses for a 13-week, Repeated Toxicity Test

2015 ◽  
Vol 18 (4) ◽  
pp. 45-50 ◽  
Author(s):  
Sungchul Kim ◽  
Eunhye Cha ◽  
Jongchul Lee ◽  
Seongjin Lee ◽  
Manyong Park ◽  
...  
Keyword(s):  
Toxicity Test ◽  
Toxicity Study ◽  
Repeated Dose ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Sprague Dawley Rats ◽  
Dose Oral

scholarly journals 26-Week Repeated Dose Oral Toxicity Study of KCHO-1 in Sprague-Dawley Rats

2019 ◽  
Vol 22 (3) ◽  
pp. 192-199
Author(s):  
Muhack Yang ◽  
Seongjin Lee ◽  
Tingting Wang ◽  
Eunhye Cha ◽  
Jongwon Jang ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Repeated Dose ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Sprague Dawley Rats ◽  
Dose Oral
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