scholarly journals Licocalchone-C Extracted from Glycyrrhiza Glabra Inhibits Lipopolysaccharide-Interferon-γ Inflammation by Improving Antioxidant Conditions and Regulating Inducible Nitric Oxide Synthase Expression

Molecules ◽  
2011 ◽  
Vol 16 (7) ◽  
pp. 5720-5734 ◽  
Author(s):  
Sara Franceschelli ◽  
Mirko Pesce ◽  
Isabella Vinciguerra ◽  
Alessio Ferrone ◽  
Graziano Riccioni ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Interferon Γ ◽  
Glycyrrhiza Glabra ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Differential regulation of arginases and inducible nitric oxide synthase in murine macrophage cells

1998 ◽  
Vol 275 (5) ◽  
pp. E740-E747 ◽  
Author(s):  
Sidney M. Morris ◽  
Diane Kepka-Lenhart ◽  
Li-Chun Chen
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Interferon Γ ◽  
Inos Expression ◽  
Murine Macrophage ◽  
Arginase Ii ◽  
Oxide Synthase ◽  
Arginase I ◽  
Inducible Nitric Oxide

Activated macrophages avidly consume arginine via the action of inducible nitric oxide synthase (iNOS) and/or arginase. In contrast to our knowledge regarding macrophage iNOS expression, the stimuli and mechanisms that regulate expression of the cytosolic type I (arginase I) or mitochondrial type II (arginase II) isoforms of arginase in macrophages are poorly defined. We show that one or both arginase isoforms may be induced in the RAW 264.7 murine macrophage cell line and that arginase expression is regulated independently of iNOS expression. For example, 8-bromo-cAMP strongly induced both arginase I and II mRNAs but not iNOS. Whereas interferon-γ induced iNOS but not arginase, 8-bromo-cAMP and interferon-γ mutually antagonized induction of iNOS and arginase I mRNAs. Dexamethasone, which did not induce either arginase or iNOS, almost completely abolished induction of arginase I mRNA by 8-bromo-cAMP but enhanced induction of arginase II mRNA. Lipopolysaccharide (LPS) induced arginase II mRNA, but 8-bromo-cAMP plus LPS resulted in synergistic induction of both arginase I and II mRNAs. In all cases, increases in arginase mRNAs were sufficient to account for the increases in arginase activity. These complex patterns of expression suggest that the arginase isoforms may play distinct, although partially overlapping, functional roles in macrophage arginine metabolism.

scholarly journals Stat1 acetylation inhibits inducible nitric oxide synthase expression in interferon-γ–treated RAW264.7 murine macrophages

Surgery ◽  
2007 ◽  
Vol 142 (2) ◽  
pp. 156-162 ◽  
Author(s):  
Lucie Guo ◽  
Hongtao Guo ◽  
Chengjiang Gao ◽  
Zhiyong Mi ◽  
William B. Russell ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Interferon Γ ◽  
Murine Macrophages ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide
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