scholarly journals Curcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer Treatment

Molecules ◽  
2011 ◽  
Vol 16 (6) ◽  
pp. 4567-4598 ◽  
Author(s):  
Purusotam Basnet ◽  
Natasa Skalko-Basnet
Keyword(s):  
Cancer Treatment ◽  
Inflammatory Molecule ◽  
Anti Inflammatory

CCN2 Functions as Anti-Inflammatory Molecule in the Intervertebral Disc

2014 ◽  
Vol 4 (1_suppl) ◽  
pp. s-0034-1376756-s-0034-1376756
Author(s):  
Makarand V. Risbud
Keyword(s):  
Intervertebral Disc ◽  
Inflammatory Molecule ◽  
Anti Inflammatory

Does vitamin D prevent radiotherapy-induced toxicity?

2019 ◽  
Vol 44 (5) ◽  
pp. 575-577
Author(s):  
Yasemin Benderli Cihan
Keyword(s):  
Vitamin D ◽  
Immune Response ◽  
Cancer Treatment ◽  
Vitamin D3 ◽  
Vitamin D Metabolites ◽  
Cytokine Levels ◽  
Anti Inflammatory ◽  
Positive Effect

AbstractVitamin D is known as the bone hormone, it is also know that it has effects on cancer because of its anti-inflammatory and immunomodulatory characteristics and its effects on cytokine levels. It is seen that vitamin D use together with radiotherapy can have a positive effect on cancer treatment. It should be investigated whether toxicities due to radiation is prevented by vitamin D metabolites’ increasing the induction of immunomodulator cells and the capacities of immune response cells. Use of 1,25[OH]2 Vitamin D3 analogs as an adjuvant immunomodulator for patients receiving radiotherapy should be evaluated. There is a need for studies to be done in this regard.

scholarly journals Copper Mediates Anti-Inflammatory and Antifibrotic Activity of Gleevec in Hepatocellular Carcinoma-Induced Male Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Iftekhar Hassan ◽  
Hossam Ebaid ◽  
Ibrahim M. Alhazza ◽  
Jameel Al-Tamimi ◽  
Shazia Aman ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transcription Factors ◽  
Cancer Treatment ◽  
Elevated Level ◽  
Antineoplastic Activity ◽  
Male Rats ◽  
Combination Group ◽  
Copper Level ◽  
Full Potential ◽  
Anti Inflammatory

The elevated level of copper is one of the hallmark features of cancer cells in most of the types of cancer. In the present study, this feature has been targeted to investigate if coadministration of exogenous copper (Cu+) and its chelating agent like disulfiram (DSF+) influence the antineoplastic activity of the anticancer drug, Gleevec (GLV+), in hepatocellular carcinoma (HCC)-induced rats via immunomodulation. After the treatment, the level of proinflammatory interleukins (IL-1, 2, 6, and 7), anti-inflammatory interleukin (IL-10) concomitant with transcription factors (NF-kB and TNF-a), and the apoptotic marker (cleaved PARP) was estimated. The cancer-induced group without treatment (CN+) demonstrated abnormally elevated level of all proinflammatory cytokines and transcription factors concomitant with a compromised level of cleaved PARP as compared to the control normal (CN-). The detailed histological analysis also supported the results exhibiting extensive inflammation and tissue fibrosis confirming the second stage of HCC. Cu+, DSF+, and GLV+ displayed mild improvement in most of the parameters, but the combination group GLV + Cu+ demonstrated remarkable recovery in histology and most of the parameters tended towards the CN- followed by GLV + DSF+. Therefore, the management of copper level is critical in realizing the antineoplastic activity of GLV up to its full potential in cancer treatment. These findings will help in improving chemoimmunotherapy and personalized cancer treatment.

Inhibition of secretory phospholipase A2 enzyme by bilirubin: A new role as endogenous anti-inflammatory molecule

2005 ◽  
Vol 276 (1-2) ◽  
pp. 219-225 ◽  
Author(s):  
Noor Mohamed Jameel ◽  
Brigitte M. Frey ◽  
Felix J. Frey ◽  
T. Veerabasappa Gowda ◽  
Bannikuppe S. Vishwanath
Keyword(s):  
Phospholipase A2 ◽  
Secretory Phospholipase A2 ◽  
Secretory Phospholipase ◽  
Inflammatory Molecule ◽  
Anti Inflammatory

Group IIA Secretory PLA2 Inhibition by Ursolic Acid: A Potent Anti-Inflammatory Molecule

2007 ◽  
Vol 7 (8) ◽  
pp. 801-809 ◽  
Author(s):  
A. Nataraj ◽  
C. Raghavendra Gowda ◽  
R. Rajesh ◽  
B. Vishwanath
Keyword(s):  
Ursolic Acid ◽  
Inflammatory Molecule ◽  
Anti Inflammatory

The intestinal microbial metabolite desaminotyrosine is an anti‐inflammatory molecule that modulates local and systemic immune homeostasis

2020 ◽  
Vol 34 (12) ◽  
pp. 16117-16128
Author(s):  
Yanxia Wei ◽  
Jing Gao ◽  
Yanbo Kou ◽  
Mengnan Liu ◽  
Liyuan Meng ◽  
...  
Keyword(s):  
Immune Homeostasis ◽  
Microbial Metabolite ◽  
Inflammatory Molecule ◽  
Anti Inflammatory

scholarly journals Endothelium-Derived 5-Methoxytryptophan Is a Circulating Anti-Inflammatory Molecule That Blocks Systemic Inflammation

2016 ◽  
Vol 119 (2) ◽  
pp. 222-236 ◽  
Author(s):  
Yi-Fu Wang ◽  
Yu-Juei Hsu ◽  
Hsu-Feng Wu ◽  
Guan-Lin Lee ◽  
Ya-Sung Yang ◽  
...  
Keyword(s):  
Systemic Inflammation ◽  
Inflammatory Molecule ◽  
Anti Inflammatory

Roles for glycosylation in the anti-inflammatory molecule CD59

1997 ◽  
Vol 25 (4) ◽  
pp. 1177-1184 ◽  
Author(s):  
P. M. Rudd ◽  
B. P. Morgan ◽  
M. R. Wormald ◽  
D. J. Harvey ◽  
C. W. van den Berg ◽  
...  
Keyword(s):  
Inflammatory Molecule ◽  
Anti Inflammatory
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