scholarly journals Quantitative Mass Spectrometry for Bacterial Protein Toxins — A Sensitive, Specific, High-Throughput Tool for Detection and Diagnosis

Molecules ◽  
2011 ◽  
Vol 16 (3) ◽  
pp. 2391-2413 ◽  
Author(s):  
Anne E. Boyer ◽  
Maribel Gallegos-Candela ◽  
Renato C. Lins ◽  
Zsuzsanna Kuklenyik ◽  
Adrian Woolfitt ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Throughput ◽  
Bacterial Protein ◽  
Quantitative Mass Spectrometry ◽  
Protein Toxins ◽  
Detection And Diagnosis

scholarly journals Monitoring the synthesis of biomolecules using mass spectrometry

2016 ◽  
Vol 374 (2079) ◽  
pp. 20150378 ◽  
Author(s):  
Masaru Miyagi ◽  
Takhar Kasumov
Keyword(s):  
Mass Spectrometry ◽  
Heavy Water ◽  
High Throughput ◽  
Biological Systems ◽  
Global Scale ◽  
Selective Synthesis ◽  
Quantitative Mass Spectrometry ◽  
Dynamic Nature ◽  
Diverse Range ◽  
Cellular Processes

The controlled and selective synthesis/clearance of biomolecules is critical for most cellular processes. In most high-throughput ‘omics’ studies, we measure the static quantities of only one class of biomolecules (e.g. DNA, mRNA, proteins or metabolites). It is, however, important to recognize that biological systems are highly dynamic in which biomolecules are continuously renewed and different classes of biomolecules interact and affect each other's production/clearance. Therefore, it is necessary to measure the turnover of diverse classes of biomolecules to understand the dynamic nature of biological systems. Herein, we explain why the kinetic analysis of a diverse range of biomolecules is important and how such an analysis can be done. We argue that heavy water ( 2 H 2 O) could be a universal tracer for monitoring the synthesis of biomolecules on a global scale. This article is part of the themed issue ‘Quantitative mass spectrometry’.

154: Integration of TPSA and High-Throughput Mass Spectrometry Data Improves Prostate Cancer Prediction

2007 ◽  
Vol 177 (4S) ◽  
pp. 52-53
Author(s):  
Stefano Ongarello ◽  
Eberhard Steiner ◽  
Regina Achleitner ◽  
Isabel Feuerstein ◽  
Birgit Stenzel ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Mass Spectrometry ◽  
High Throughput ◽  
Mass Spectrometry Data ◽  
Cancer Prediction
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