scholarly journals Tetrabutylammonium Bromide Media Aza-Michael Addition of 1,2,3,6-Tetrahydrophthalimide to Symmetrical Fumaric Esters and Acrylic Esters under Solvent-Free Conditions

Molecules ◽  
2010 ◽  
Vol 15 (10) ◽  
pp. 7353-7362 ◽  
Author(s):  
Gholamhassan Imanzadeh ◽  
Farzaneh Ahmadi ◽  
Mohammadreza Zamanloo ◽  
Yagoub Mansoori
Keyword(s):  
Michael Addition ◽  
Tetrabutylammonium Bromide ◽  
Solvent Free ◽  
Solvent Free Conditions ◽  
Acrylic Esters

Zinc oxide-tetrabutylammonium bromide tandem as a highly efficient, green, and reusable catalyst for the Michael addition of pyrimidine and purine nucleobases to α,β-unsaturated esters under solvent-free conditions

2008 ◽  
Vol 86 (4) ◽  
pp. 317-324 ◽  
Author(s):  
Abdolkarim Zare ◽  
Alireza Hasaninejad ◽  
Mohammad Hassan Beyzavi ◽  
Abolfath Parhami ◽  
Ahmad Reza Moosavi Zare ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Michael Addition ◽  
Tetrabutylammonium Bromide ◽  
Solvent Free ◽  
Reusable Catalyst ◽  
Efficient Procedure ◽  
Unsaturated Esters ◽  
Microwave Assisted ◽  
Solvent Free Conditions ◽  
The Michael Addition

An efficient procedure for the synthesis of carboacyclic nucleosides via microwave-assisted Michael addition of pyrimidine and purine nucleobases to α,β-unsaturated esters in the presence of catalytic amounts of zinc oxide (ZnO) and tetrabutylammonium bromide (TBAB) is described. The reactions proceed rapidly in good to excellent yields.Key words: ZnO–TBAB, green chemistry, Michael addition, nucleobase, solvent-free, microwave.

Highly efficient regioselective synthesis of pyrroles via a tandem enamine formation–Michael addition–cyclization sequence under catalyst- and solvent-free conditions

2015 ◽  
Vol 17 (6) ◽  
pp. 3415-3423 ◽  
Author(s):  
Thavaraj Vivekanand ◽  
Perumal Vinoth ◽  
B. Agieshkumar ◽  
Natarajan Sampath ◽  
Arumugam Sudalai ◽  
...  
Keyword(s):  
Column Chromatography ◽  
Michael Addition ◽  
Solvent Free ◽  
Regioselective Synthesis ◽  
Highly Efficient ◽  
Solvent Free Conditions ◽  
Enamine Formation

An efficient three-component, catalyst-, solvent-, and column chromatography-free procedure was developed for the synthesis of 3-(1H-pyrrol-3-yl)indolin-2-ones.

Use of (R)-Mandelic Acid as Chiral Co-Catalyst in the Michael Addition Reaction Organocatalyzed by (1S,4S)-2-Tosyl-2,5-diazabicyclo[2.2.1]heptane under Solvent-Free Conditions

2015 ◽  
Vol 2 (1) ◽  
Author(s):  
C. Gabriela Ávila-Ortiz ◽  
Manuel López-Ortiz ◽  
Alberto Vega-Peñaloza ◽  
Ignacio Regla ◽  
Eusebio Juaristi
Keyword(s):  
Michael Addition ◽  
Mandelic Acid ◽  
Addition Reaction ◽  
Solvent Free ◽  
Reaction Intermediates ◽  
Michael Addition Reaction ◽  
Co Catalyst ◽  
Co Catalysts ◽  
Solvent Free Conditions ◽  
The Michael Addition

AbstractThis article describes a study on the Michael addition reaction of cyclohexanone to nitroolefins catalyzed by the chiral secondary amine (1S,4S)-2-tosyl- 2,5-diazabicyclo[2.2.1]heptane. Reactions were carried out under solvent-free conditions to make them more environmentally friendly. Initially, the observed diastereoand enantioselectivities were moderate to good, but were significantly improved by lowering the reaction temperature. Furthermore, a variety of chiral acids were also tested as co-catalysts in both of their enantiomeric forms, which revealed that (R)-mandelic acid affords excellent results in terms of yield and stereoselectivity. Monitoring the reaction by MS-TOF allowed for the detection of key reaction intermediates, and a reasonable reaction mechanism in which both catalysts are involved is proposed.

scholarly journals Cyanuric Chloride-Catalyzed Michael Addition of Indoles to Nitroolefins under Solvent-Free Conditions

2013 ◽  
Vol 2013 ◽  
pp. 1-5
Author(s):  
Xiao Juan Yang ◽  
Yun Jing
Keyword(s):  
Michael Addition ◽  
Present Method ◽  
Solvent Free ◽  
Cyanuric Chloride ◽  
Reaction Conditions ◽  
Experimental Procedure ◽  
Solvent Free Conditions ◽  
Short Period ◽  
The Michael Addition ◽  
Solvent Free Reaction

Cyanuric chloride is an inexpensive, efficient, and mild catalyst for the Michael addition of indoles to nitroolefins at 70°C under solvent-free conditions. The simple experimental procedure, solvent-free reaction conditions, utilization of an inexpensive and readily available catalyst, short period of conversion, and excellent yields are the advantages of the present method.

scholarly journals Green Michael addition of thiols to electron deficient alkenes using KF/alumina and recyclable solvent or solvent-free conditions

2009 ◽  
Vol 20 (1) ◽  
pp. 93-99 ◽  
Author(s):  
Eder J. Lenardão ◽  
Danusia O. Trecha ◽  
Patrícia da C. Ferreira ◽  
Raquel G. Jacob ◽  
Gelson Perin
Keyword(s):  
Michael Addition ◽  
Solvent Free ◽  
Solvent Free Conditions
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