scholarly journals 2-Amido-3-(1H-Indol-3-yl)-N-Substitued-Propanamides as a New Class of Falcipain-2 Inhibitors. 1. Design, Synthesis, Biological Evaluation and Binding Model Studies

Molecules ◽  
2009 ◽  
Vol 14 (1) ◽  
pp. 494-508 ◽  
Author(s):  
Jin Zhu ◽  
Tong Chen ◽  
Lili Chen ◽  
Weiqiang Lu ◽  
Peng Che ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Binding Model ◽  
Design Synthesis ◽  
Model Studies ◽  
New Class

scholarly journals Design, synthesis and biological evaluation of 2-aminopyrimidinones and their 6-aza-analogs as a new class of CK2 inhibitors

2013 ◽  
Vol 29 (5) ◽  
pp. 639-646 ◽  
Author(s):  
Maksym O. Chekanov ◽  
Olga V. Ostrynska ◽  
Sergii S. Tarnavskyi ◽  
Anatoliy R. Synyugin ◽  
Nadiia V. Briukhovetska ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
New Class ◽  
Synthesis And Biological Evaluation ◽  
Ck2 Inhibitors

Design, Synthesis and Biological Evaluation of Benzimidazole-pyridine- Piperidine Hybrids as a New Class of Potent Antimicrobial Agents

2014 ◽  
Vol 12 (1) ◽  
pp. 38-45 ◽  
Author(s):  
Kothapally. Beulah ◽  
Akula Kumara ◽  
Boddupally Lingaiah ◽  
Pamulaparthy Rao ◽  
Banda Narsaiah ◽  
...  
Keyword(s):  
Antimicrobial Agents ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
New Class ◽  
Synthesis And Biological Evaluation

Design, Synthesis, Molecular Docking and Biological Evaluation of Bromo-Pyridyl Containing 3-Chloro 2-Azetidinone Derivatives as Potential Antimycobacterial Agents

2021 ◽  
Author(s):  
Rakesh V. Kusurkar ◽  
Rahul H. Rayani ◽  
Anand G. Vala ◽  
Deepa R. Parmar ◽  
Manoj N Bhoi ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Antitubercular Activity ◽  
Docking Studies ◽  
Biological Evaluation ◽  
Dynamics Simulation ◽  
Design Synthesis ◽  
H Nmr ◽  
New Class ◽  
Lactam Ring ◽  
C Nmr

Abstract A new class of β-lactam pharmacophore series of 2-Bromo-N-[4-(2-{[2-(substituted phenyl)-3-chloro-4-oxoazetidin-1-yl] amino}-2-oxoethyl) phenyl] pyridine-4-carboxamide derivatives were designed, prepared, and screened for their antimycobacterial activities. The hydrazone derivatives were first synthesized via conventional and microwave methods, and then the β-lactam ring could be constructed via a [2+2] ketenimine cycloaddition. The structure of all synthesized compounds was characterized by FTIR, 1H NMR, 13C NMR, and Mass spectroscopy techniques. All the newly synthesized derivatives were found to be effective in inhibiting M. tuberculosis H37RV strain infection at concentrations of 12.5, 25.0, and 50.0 µg/mL using the MABA method. Amongst, the compound (6e) was found to be good potent antitubercular activity at 12.5 mg/mL concentration in comparison with the rest of the compounds using the standard therapeutic agent Streptomycin. Molecular dynamics simulation studies and Molecular docking studies have been performed against mycobacterial InhA enzyme to gain an insight into the possible mechanistic action in search of good potent antitubercular candidates.

scholarly journals Design, synthesis and biological evaluation of 2-alkoxycarbonyl-3-anilinoindoles as a new class of potent inhibitors of tubulin polymerization

2020 ◽  
Vol 97 ◽  
pp. 103665 ◽  
Author(s):  
Romeo Romagnoli ◽  
Filippo Prencipe ◽  
Paola Oliva ◽  
Maria Kimatrai Salvador ◽  
Andrea Brancale ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Tubulin Polymerization ◽  
Design Synthesis ◽  
New Class ◽  
Synthesis And Biological Evaluation

Oligocarbamate Molecular Transporters:  Design, Synthesis, and Biological Evaluation of a New Class of Transporters for Drug Delivery

2002 ◽  
Vol 124 (45) ◽  
pp. 13382-13383 ◽  
Author(s):  
Paul A. Wender ◽  
Jonathan B. Rothbard ◽  
Theodore C. Jessop ◽  
Erik L. Kreider ◽  
Bryan L. Wylie
Keyword(s):  
Drug Delivery ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Molecular Transporters ◽  
New Class ◽  
Synthesis And Biological Evaluation
Sign in / Sign up

Export Citation Format

Share Document