scholarly journals The Vitamin D, IL-6 and the eGFR Markers a Possible Way to Elucidate the Lung–Heart–Kidney Cross-Talk in COVID-19 Disease: A Foregone Conclusion

2021 ◽  
Vol 9 (9) ◽  
pp. 1903
Author(s):  
Mario Giosuè Balzanelli ◽  
Pietro Distratis ◽  
Rita Lazzaro ◽  
Angelo Cefalo ◽  
Orazio Catucci ◽  
...  
Keyword(s):  
Vitamin D ◽  
Control Group ◽  
Healthy Individuals ◽  
Low Level ◽  
The Core ◽  
Immune Mediated ◽  
Main Pathway ◽  
Glomerular Filtrate ◽  
High Level ◽  
Lung Impairment

Background: Based on recent findings, we speculated the existence of the lung, heart, and kidney axis as the main pathway for the COVID-19 disease progression. Methods: This paper reports on an observational study conducted by a team of researchers and doctors of the 118-Pre-Hospital and Emergency Department of SG Moscati of Taranto City in Italy. The study was conducted on a totality of 185 participants that were divided into three groups. The study group included COVID-19 affected patients (PP n = 80), the first control group included patients with different pathologies (non-COVID-19 NNp n = 62) of the SG Moscati Hospital, and the second control group included healthy individuals (NNh n = 43). The core of the current trial was focused on assessing the level of the vitamin D (serum 25(OH) D concentration), IL-6, and the renal glomerular filtrate (eGFR) in COVID-19 disease and non-COVID-19 patients in both groups. Results: It was observed that the majority of COVID-19-infected patients showed a progressive multi-organ involvement, especially in regard to the lung, kidney, and heart. The majority of the COVID-19 patients exhibited preexisting comorbidities which include cardiovascular, respiratory, and renal disorders accompanied by a severely low level of vitamin D, extremely high level of IL-6, and low glomerular filtration rate (eGFR). The significant overall damages exerted by the immune-mediated responses under the hyper-expression of proinflammatory cytokines and interleukins, such as IL-6, may be facilitated by either a decreased level of vitamin D or the ageing process. The reduced presence of vitamin D was often found together with a reduced functionality of renal activity, as revealed by the low eGFR, and both were seen to be concomitant with an increased mortality risk in patients with lung disorders and heart failure (HF), whether it is showed at baseline or it develops during manifestation of COVID-19. Therefore, the documentation of the modifiable risk factors related to SARS-CoV-2 and lung impairment in older patients with kidney and heart disease may help the clinician to better manage the situation. Conclusions: This paper addresses how a low level of vitamin D and older age may be indicative of systemic worsening in patients with COVID-19, with a goal of providing a broader context in which to view a better therapeutic approach.

Comparison of Spoilage Rates in Ground Turkey and Ground Beef

1992 ◽  
Vol 55 (7) ◽  
pp. 518-521 ◽  
Author(s):  
N. J. STERN ◽  
C. E. LYON ◽  
M. T. MUSGROVE ◽  
J. A. DICKENS ◽  
R. L. WILSON
Keyword(s):  
Muscle Tissue ◽  
Ground Beef ◽  
Control Group ◽  
Origin Of Species ◽  
Low Level ◽  
Livestock Species ◽  
Plastic Bags ◽  
Significant Difference ◽  
Uninoculated Control ◽  
High Level

Spoilage rates of ground turkey and ground beef were compared. Clean muscle tissue of the two livestock species were ground in a hygienic manner, providing initial mesotrophic counts (72 h at 25°C) in the range of ca. 102–3 CFU/g. Moisture, fat, and protein contents for the ground products were similar. Each ground product was subjected to the following treatments: a) uninoculated control, b) inoculated with a low level of turkey flora, c) inoculated with a high level of turkey flora, d) inoculated with a low level of beef flora, and e) inoculated with a high level of beef flora. Three replicate analyses were performed on the products which were held at 5°C in air-permeable plastic bags. Five subsamples (20–25 g) were taken for each of the five analysis times over 10 d of storage. At completion of storage, bacterial counts varied from 103.5 to 109.2 CFU/g, with the turkey control group at the lower end of the range. Our findings indicate no significant difference between the spoilage rates of the two ground products, regardless of treatment or origin of species.

scholarly journals Prognosis of progression of chronic generalised periodontitis in patients with bronchiectatic disease

2020 ◽  
Vol 27 (1) ◽  
pp. 72-84
Author(s):  
Artem K. Sarkisov ◽  
Vladimir A. Zelenskiy ◽  
Ekaterina A. Polunina ◽  
Karen A. Sarkisov
Keyword(s):  
Oxidative Stress ◽  
Mathematical Model ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Binary Logistic Regression ◽  
Control Group ◽  
Healthy Individuals ◽  
Logistic Regression Method ◽  
High Level ◽  
And Oxidative Stress

Aim. To analyse the parameters of dental indices and the level of markers of infl ammation and oxidative stress in patients with chronic generalised periodontitis (CGP) with bronchiectatic disease and to develop a mathematical model for assessing the risk of CGP progression in patients with bronchiectatic disease.Materials and methods. A total of 70 patients with mild and moderate CGP were examined, which were divided into the following groups: patients with CGP without general somatic pathology (n = 33), and patients with CGP and bronchiectatic disease (n = 37). The control group consisted of somatically healthy individuals with intact periodontium (n = 40). Dental indices (PMA, PI, Muhlemann, OHI-s), infl ammatory markers (transforming growth factor beta 1 (TGFβ-1), lactoferrin (LF), interleukin-8 (IL-8), C — reactive protein (CRP)), and oxidative stress markers (malondialdehyde (MDA), as well as advanced oxidation protein products (AOPPs), and total superoxide dismutase (SOD)) were analysed in all patients included in the study. The method of binary logical regression was used to create a mathematical model for assessing the risk of CGP progression in patients with bronchiectatic disease.Results. Dental indices and the level of markers of infl ammation and oxidative stress were statistically signifi cantly higher in all patients with CGP as compared to somatically healthy individuals, as well as in patients with CGP and bronchiectatic disease as compared to patients with CGP without general somatic pathology. Positive correlations of different strength between the studied markers of infl ammation and oxidative stress and dental indices were revealed. Based on the results of the correlation matrix data and using the binary logistic regression method, a mathematical model was developed that can be applied for assessing the risk of CGP progression in patients with bronchiectatic disease. The predictors of progression included in the mathematical model were: PI, TGFβ-1 and AOPPs. Conclusion. The data obtained indicate a greater severity of infl ammation and oxidative stress in CGP patients with comorbid pathology in the form of bronchiectatic disease and the infl uence of these processes on the periodontal condition. The proposed mathematical model for assessing the risk of CGP progression in patients with bronchiectatic disease is characterized by a high level of sensitivity and prognostic signifi cance, thus being applicable for use in clinical practice. 

scholarly journals Low Level of Vitamin D is Correlated with High C-Reactive Protein (CRP) and Disease Activity in Indonesian Juvenile Idiopathic Arthritis (JIA) Patients

2020 ◽  
Vol 12 (2) ◽  
pp. 149-56
Author(s):  
Desy Wulandari ◽  
Wisnu Barlianto ◽  
Tita Luthfia Sari
Keyword(s):  
Vitamin D ◽  
Juvenile Idiopathic Arthritis ◽  
Serum Level ◽  
Disease Activity ◽  
Vitamin D Deficiency ◽  
Control Group ◽  
Healthy Children ◽  
C Reactive Protein ◽  
Low Level ◽  
Reactive Protein

BACKGROUND: Vitamin D plays essential role in the regulation of inflammation, such as in pathogenesis of Juvenile Idiopathic Arthritis (JIA). Vitamin D deficiency has been reported among JIA patients, but there were conflicting results regarding the correlation with disease activity. This study aimed to assess vitamin D serum level and its correlation with C-Reactive Protein (CRP) and disease activity in JIA patients.METHODS: Children who were diagnosed with JIA according to International League of Associations for Rheumatology (ILAR) criterias were enrolled as JIA group subjects, while age and sex-matched healthy children were enrolled as the control group subjects. Vitamin D and CRP serum level were measured. Disease activity of JIA patients was calculated by Juvenile Arthritis Disease ActivityScore-27 (JADAS-27).RESULTS: Vitamin D serum level was lower in the JIA group compared to the healthy control group (p=0.000). Among 26 JIA patients, 61.5% were deficient, 30.8% were insufficient, and 7.7% had normal vitamin D. No significant different in CRP level between vitamin D group (p=0.441), but there was significant different in JADAS-27 (p=0.001). The mean of CRP and JADAS-27 were found highest in vitamin D deficiency group. Vitamin D serum level was negatively correlate with CRP (p=0.021, r=-0.452) and JADAS-27 (p=0.001 r=-0.595).CONCLUSION: Low level of vitamin D in JIA patients was inversely related to higher CRP and disease activity,suggesting that vitamin D supplementation could be havepotential role in JIA treatment.KEYWORDS: vitamin D, CRP, disease activity,JADAS-27, JIA

scholarly journals FMS assessment and core stability in a group of amateur climbers

2021 ◽  
Vol 25 (1) ◽  
Author(s):  
Joanna Golec ◽  
Kinga Cieślik ◽  
Monika Nowak ◽  
Eżbieta Szczygieł ◽  
Justyna Golec
Keyword(s):  
Core Stability ◽  
Trunk Muscles ◽  
Rotational Stability ◽  
Control Group ◽  
Stability Tests ◽  
The Core ◽  
Functional Efficiency ◽  
Endurance Tests ◽  
Positive Correlations ◽  
High Level

Background: The objective of the study was to assess the functional status of people who regularly climb for recreational purposes, using the FMS (Functional Movement Screen) and core stability tests (McGill's torso muscular endurance tests). This paper also attempts to determine the relation between the assessment of functional efficiency and the results obtained in core stability tests. Material and methods: The study group were consisted of 30 amateur climbers (aged 26 ±3), who were compared to a control group of 30 people who don’t climb but recreationally practice volleyball (aged 22 ±3). All participants performed each of the seven FMS trials and the three McGill's tests. Results: Amateur climbers, in comparison to non-climbers, were achieved higher scores in each of the core stability trials (p<0,05). Climbers also scored significantly higher results in all FMS trials as well as in the final average (19,0 3 ±1,54 vs. 16,60 ±3,60; p<0,01). In addition, there were found positive correlations between FMS and core stability trials in the group of climbers (Deep Squad vs. Side bridge test; In-Line Lunge vs. Side bridge test; Rotational Stability vs. all trials of the core stability test). Conclusions: People recreational practicing climbing are characterized by a high level of functional efficiency and above-average levels of deep trunk muscles endurance, responsible for the proper functioning of the central stabilization. Relationship between the overall results of the FMS and the core stability tests in the climbers' group shows that proper stability training, which is a part of the climbers training, may result in higher athletes’ performance.

P–564 Analysis of efficiency and outcomes of assisted reproductive technology (ART) programs after embryo transfer with a low-level of mosaicism

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
M Shishimorova ◽  
S Tevkin ◽  
T Jussubaliyeva
Keyword(s):  
Embryo Transfer ◽  
Live Birth ◽  
Live Birth Rate ◽  
Control Group ◽  
Art Programs ◽  
Low Level ◽  
Mosaic Embryo ◽  
Group A ◽  
Group B ◽  
High Level

Abstract Study question How does embryo transfer with a low-level of mosaicism affect the success of ART programs, pregnancy, and live birth in comparison with euploid embryo transfer? Summary answer The transfer of mosaic embryos results in the delivery of a healthy baby however significantly decreases the outcome of ART programs and live birth rate. What is known already Present methods of preimplantation genetic testing of aneuploidy (PGT-A) allow detecting a mixture of euploid and aneuploid cells at the blastocyst stage with high accuracy. Such embryos are classified as mosaics with varying levels according to the guidelines of the International Society for Preimplantation Genetic Diagnosis (PGDIS). Numerous sources describe that number of mosaic embryos can vary from 4 to 22%. Several publications report that mosaic embryos can lead to successful pregnancies and healthy childbirth, but with a lower frequency and higher rates of pregnancy loss compared to euploid embryos. Nevertheless, the effect of mosaicism on ART outcomes remains controversial. Study design, size, duration It has been analyzed 2506 embryos from 648 patients undergoing the ART program with PGT-A at the Institute of Reproductive Medicine for 2018 - 2019. Embryos after PGT-A were classified as euploid, aneuploid, and having mosaicism of less than 40% as low level and more than 40% as high level following PGDIS guidelines. Patients of (group A) were transferred 467 single euploid embryos, and 43 patients (group B) underwent single low-level mosaic embryo transfer. Participants/materials, setting, methods The embryos on day 5 or 6 were graded by Gardner Scoring System. Approximately 5–10 TE cells were biopsied from good quality blastocysts and subsequently vitrified. PGT-A was performed utilizing an array comparative genomic hybridization (aCGH) (Agilent). The transfer of mosaic embryos was performed in the absence of an alternative, only after medical genetic counseling with a risk explanation and the subsequent signing of an informed agreement. Statistical tests processed by Pearson’s chi-squared test. Main results and the role of chance Of all analyzed embryos, the proportion of euploid embryos was 48.6% (n = 1002), the total number of mosaics was 18.6% (n = 384) and aneuploid ones were 32.8% (n = 676). Depending on the level of mosaicism, the ratio between embryos with low-level mosaicism (≤40%) / high-level (≥40%) was 38.3% / 61.7%, respectively. According to the study, there was a significant decrease in the indicator of clinical pregnancy rate after embryo transfer with a low-level of mosaicism of 44.1% versus 63.2% transferred euploid embryo (р&lt;0,01), however, despite an increase losses pregnancy in the group B (26.3%) there was no significant difference (p = 0.16) in comparison with the control group (15.4%). The live birth rate (LBR) significantly decreased (p &lt; 0.001) after the transfer of the mosaic embryo by 32.5%, while in the control group the indicator was 53.9%. In all cases, after the transfer of the mosaic embryo, healthy babies were born. There were 2 cases of high-level mosaic embryo transfer as a result of which pregnancy did not occur. According to the survey, about 70% of patients agree to replant mosaic embryos, 20% are ready to go to the new program, and 10% cannot make a decision. Limitations, reasons for caution The number of patients in group B was significantly lower than in group A. Not enough cases of embryo transfer with a high-level of mosaicism. Wider implications of the findings: The current study might help to develop and to select a more appropriate strategy for transfer mosaic embryos. The next series of studies should focus on obstetric and neonatal outcome data from mosaic embryo transfer to gain a better understanding of the chromosomal and physiological health of children. Trial registration number Not applicable

Alexithymia and body-self relations among patients with alopecia areata

Physiotherapy ◽  
2014 ◽  
Vol 22 (2) ◽  
Author(s):  
Marta Kuty-Pachecka ◽  
Katarzyna Stefańska
Keyword(s):  
Alopecia Areata ◽  
Psychological Evaluation ◽  
Control Group ◽  
Healthy Individuals ◽  
Toronto Alexithymia Scale ◽  
Integral Treatment ◽  
Body Self ◽  
High Level

AbstractThe aim of the study: The aim of the study was the assessment of alexithymia and body-self relations among patients with alopecia areata.Material and methods: The study included 79 people: 30 with alopecia areata and 49 healthy individuals, showing no psychodermatological disorders (control group). During the study, Toronto Alexithymia Scale (TAS-26) and the Multidimensional Body-Self Relations Questionnaire (MBSRQ) were used.Results: The subjects had a high level of alexithymia. Moreover, the persons less satisfied with their bodies dominated in the group diagnosed with alopecia areata.Conclusions: Alexithymia and lesser satisfaction with own is characteristic for patients with alopecia areata. These data suggest that it is necessary to make a proper psychological evaluation for integral treatment of alopecia areata.

scholarly journals Vitamin D Metabolism Alteration in Acromegaly and Its Impact on Calcium-Phosphorus Metabolism

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A651-A652
Author(s):  
Alexandra Povaliaeva ◽  
Liudmila Rozhinskaya ◽  
ScD, Artem Zhukov ◽  
Ekaterina A Pigarova ◽  
ScD, Larisa K Dzeranova ◽  
...  
Keyword(s):  
Vitamin D ◽  
Biochemical Parameters ◽  
Control Group ◽  
Vitamin D Metabolites ◽  
Phosphorus Metabolism ◽  
Total Calcium ◽  
Healthy Individuals ◽  
Hydroxylase Activity ◽  
Calcium Phosphorus ◽  
Calcium And Phosphorus

Abstract Objective: to evaluate metabolism of vitamin D and calcium-phosphorus metabolism in patients with an active phase of acromegaly in comparison with healthy individuals. Materials and Methods: The study included 44 patients with an active acromegaly (IGF-1 788 [521; 963] ng/mL), as well as 49 conditionally healthy individuals. There were more men in the Acromegaly group (41% vs. 20%, p &lt;0.05), patients were older (median age 42.7 [35.5; 26.5] vs. 26.3 [25; 33.5] years, p &lt;0.05) and had a higher BMI (28.4 [25.2; 30.2] vs. 22.2 [20.1; 26.1] kg/m2, p &lt;0.05) in a minor way compared with the control group. All participants were tested for vitamin D metabolites (25(OH)D3, 25(OH)D2, 1,25(OH)2D3, 3-epi-25(OH)D3 and 24,25(OH)2D3) by UPLC-MS/MS, free 25(OH)D and vitamin D-binding protein by ELISA, PTH by electrochemiluminescence immunoassay, as well as routine biochemical parameters of blood serum (calcium, phosphorus, creatinine, albumin, magnesium) and urine (calcium and phosphorus-creatinine ratio in spot urine). Results: In the Acromegaly group, we observed significantly higher levels of serum total calcium (2.46 [2.37; 2.56] vs. 2.38 [2.33; 2.45] mmol/L, p &lt;0.05), albumin-corrected calcium (2.33 [2.28; 2.42] vs. 2.26 [2.21; 2.31] mmol/L, p &lt;0.05) and phosphorus (1.39 [1.25; 1.55] vs. 1.15 [1.06; 1.23] mmol/L, p &lt;0.05) as well as lower levels of serum albumin (45 [44; 47] vs. 46 [45; 48] g/L, p &lt;0.05). The rest of the studied biochemical parameters and PTH levels did not differ significantly between the groups. The IGF-1 level in patients with acromegaly positively correlated with the level of total calcium (r = 0.49, p &lt;0.05), albumin-corrected calcium (r = 0.49, p &lt;0.05) and phosphorus (r = 0.55, p &lt;0.05). The Acromegaly group showed lower levels of 25(OH)D3 (14.8 [11.8; 20.5] vs. 20.5 [14.8; 24.6] ng/mL, p &lt;0.05), 3-epi-25(OH)D3 (1.0 [0.7; 1.4] vs. 1.4 [0.9; 1.8] ng/mL, p &lt;0.05), 24,25(OH)2D3 (0.8 [0.4; 1.2] vs. 1.7 [0.9; 2.6] ng/ml, p &lt;0.05) and free 25(OH)D (4.6 [3.7; 5.6] vs. 5.9 [4.0; 7.5] pg/mL, p &lt;0.05), higher levels of 1,25(OH)2D3 (50 [42; 63] vs. 39 [34; 45] pg/mL, p &lt;0.05), a lower 25(OH)D3/1,25(OH)2D3 ratio (289 [226; 443] vs. 517 [340; 641], p &lt;0.05) and a higher 25(OH)D3/24,25(OH)2D3 ratio (19.3 [15.4; 27.7] vs. 11.9 [9.6; 15.2], p &lt;0.05). Conclusion: Our data suggest that high levels of the active vitamin D metabolite (1,25(OH)2D3) resulting from an increase in 1α-hydroxylase activity may contribute to the elevation of calcium and phosphorus serum levels in patients with acromegaly. Our results also indicate a decrease in 24-hydroxylase activity in patients with acromegaly, which may be due to lower levels of 25(OH)D3 in these patients. The results obtained should be evaluated taking into account the observed differences in age, gender and BMI between groups.

scholarly journals MON-390 Vitamin D Metabolism in Patients with Acromegaly: A Case-Control Pilot Study

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Alexandra Povaliaeva ◽  
Ekaterina Pigarova ◽  
Artem Zhukov ◽  
Larisa Dzeranova ◽  
Victor Bogdanov ◽  
...  
Keyword(s):  
Vitamin D ◽  
Biochemical Parameters ◽  
Reference Interval ◽  
Control Group ◽  
Vitamin D Metabolites ◽  
Phosphorus Metabolism ◽  
Creatinine Ratio ◽  
Healthy Individuals ◽  
Blood Calcium ◽  
Calcium Phosphorus

Abstract Objective: to study the differences in the metabolism of vitamin D and calcium-phosphorus metabolism in patients with an active phase of acromegaly in comparison with healthy individuals. Materials and methods: The study included 8 patients with an active acromegaly, median age 36.5 ± 6.25 years, BMI 27.9 ± 1.95 kg/m2, IGF-1 907.3 ± 239 ng/ml, as well as 8 conditionally healthy individuals selected by age, sex and level of 25(OH)D determined by the immunochemiluminescent method (DEQAS certified). All participants were tested for calcium-phosphorus metabolism, PTH, and vitamin D metabolites by HPLC/MS-MS (25(OH)D3, 25(OH)D2, 3-epi-25(OH)D3 and 24,25(OH)2D3) before oral administration of 150 000 IU of an aqueous solution of cholecalciferol and 7 days after administration. Results: In the Acromegaly group, on the 7th day after taking the drug, there was a statistically significant increase in 25(OH)D3 (89.8 ± 10.5 vs. 54.1 ± 14.8 nmol/L), 3-epi-25(OH)D3 (9.0 ± 2.6 vs. 3.3± 1.1 nmol/L) and 24,25(OH)2D3 (8.3 ± 1.9 vs. 6.4 ± 2.1 nmol/L), and a decrease of 25(OH)D2 (0.8 ± 0.2 vs. 1.1 ± 0.3 nmol/L) and a ratio of 24,25(OH)2D3 to 25(OH)D3 (0.1 ± 0.02 vs. 0.13 ± 0.03). A statistically significant increase in albumin-adjusted calcium was also noted (2.39 ± 0.14 vs. 2.31 ± 0.13 mmol/L). The medians of the levels of PTH and phosphorus initially were 27.1 ± 13.5 pg/ml and 1.6 ± 0.3 mmol/l and did not change by day 7 after taking the drug; creatinine and magnesium levels also remained the same. The level of calcium-creatinine ratio in a single portion of urine (CCR) was initially within the reference interval for all patients, its median did not change by day 7, however, in two patients there was a clinically insignificant increase higher than the upper limit of the reference interval; the phosphorus-creatinine ratio in a single portion of urine increased significantly. In the control group, after taking cholecalciferol similar changes in the levels of the studied vitamin D metabolites were observed, the levels of PTH also remained the same, however, there were no changes in the median biochemical parameters of blood and urine by day 7 after drug intake. Among the studied vitamin D metabolites, there were initially no significant differences between the groups; on day 7 a difference was recorded for the level of 3-epi-25(OH)D3 (9.0 ± 2.6 in the Acromegaly group vs. 18.8 ± 8.9 nmol/L in the control group). Among the biochemical parameters in the Acromegaly group higher levels of ionized blood calcium (1.14 ± 0.05 vs 1.1 ± 0.03 mmol/L), blood phosphorus (1.61 ± 0.26 vs 1.15 ± 0.09 mmol/L) and CCR were observed. Conclusion: Loading dose of cholecalciferol in patients with acromegaly is associated with less production of 3-epi-25(OH)D3, and results in lower inactive fraction of vitamin D than in healthy controls. More studies are needed to evaluate the effect of 1.25(OH)2D3 level on calcium-phosphorus metabolism in acromegaly.

scholarly journals Clinical and metabolic parameters, Ca2+, parathormone depending on serum 25(OH)D concentration in hypertensive patients in the West-Ukrainian population

2021 ◽  
Vol 11 (12) ◽  
pp. 150-157
Author(s):  
Marianna Semianiv ◽  
Larysa Sydorchuk
Keyword(s):  
Vitamin D ◽  
Clinical Symptoms ◽  
Hypovitaminosis D ◽  
Metabolic Parameters ◽  
Total Serum ◽  
Control Group ◽  
Healthy Individuals ◽  
The West ◽  
Hypertensive Patients ◽  
Lipid Panel

Introduction. Low plasma levels of 25-OH vitamin D (25(OH)D) have been associated with an increased prevalence of hypertension. The purpose of the research was to establish the association of clinical and metabolic parameters, Ca2+, parathormone and serum 25(OH)D concentration in hypertensive patients in the West-Ukrainian population. Material and method. 100 subjects with essential arterial hypertension (EAH) and target-organ damaging (2nd stage), moderate, high, very high cardiovascular risk were involved in the case-control study. Among them, 70,84% females, 29,16% males, mean age 57,86±7,81 yo. The control group consisted of 60 healthy individuals. All recruited patients were examined for heart rate, systolic and diastolic blood pressure (SBP, DBP); SCORE, BMI, waist and hip circumference (WC, HC); lipid panel, serum glucose and ionized calcium, 25(OH)D, parathormone levels were studied. Patients were divided into groups depending on total serum 25(OH)D concentration. Results. Low 25(OH)D concentration (<30 ng/ml) in patients with EAH was associated with arrhythmia, headache, sleep disturbance, weakness, fatigue, and increased total 10-year risk for fatal CVD SCORE>5,0%. We found higher SBP and DBP by 9,12% (р=0,014) and 5,17% (р=0,047), higher BMI in men and women – by 20-28,11% (р<0,05), as well as higher values of WC and HC by 8,69-11,92% (р<0,05) in hypertensive patients with hypovitaminosis D. In addition, obesity (BMI≥30,0 kg/m2), hyperglycemia, hypertriglyceridemia was more frequent – by 43% (p<0,05), 43,13% (p<0,001) and 59,37% (p=0,023), respectively. The level of ionized Ca2+ was slightly higher in healthy individuals (p=0,047) with low vitamin D concentration. PTH was compensatory increased by 31,85% (p=0,048) in hypertensive patients with hypovitaminosis D. Conclussions. Hypovitaminosis D is associated with more severe metabolic, hemodynamic disorders and clinical symptoms in hypertensive patients in the West-Ukrainian population.

Development of Thinking Skills in Early Childhood

2019 ◽  
Vol 1 (1) ◽  
pp. 46-60
Author(s):  
Siti Aisyah
Keyword(s):  
Early Childhood ◽  
Language Skills ◽  
Thinking Skills ◽  
Control Group ◽  
Low Level ◽  
Reading Methods ◽  
Calculation Results ◽  
High Level ◽  
Reading Activities ◽  
Two Sides

This research aims to obtain empirical data on the effect of reading method and thinking skills toward intelligence language of early childhood. Thus the researchers wanted to investigate the causal relationship between the reading method and thinking skills with the intelligence language of children by giving treatment to the experimental group and compared it with the control group. This study used a treatment design by level 2 x 2 be In the design, each of the independent variables are classified into two sides, includes action variable that is reading methods (A) are classified into the Big Book Methods (A1) and Syllables Method (A2). Whereas moderator variables that is thinking skills (B), are classified based on high and low level into high-level thinking skills (B1) and low-level thinking skills (B2). ANOVA calculation results showed that language skills of children who followed reading activities by using the Big Book method is higher than the language skills of children who attend reading activities by using Syllables method. Thus, there is the effect of the application of the Big Book method and Syllables methods toward language skills of children.

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