scholarly journals Association of Skin Microbiome with the Onset and Recurrence of Pressure Injury in Bedridden Elderly People

2021 ◽  
Vol 9 (8) ◽  
pp. 1603
Author(s):  
Shigefumi Okamoto ◽  
Kazuhiro Ogai ◽  
Kanae Mukai ◽  
Junko Sugama
Keyword(s):  
Blood Flow ◽  
Elderly People ◽  
Skin Surface ◽  
Review Article ◽  
The Body ◽  
Health Hazards ◽  
Skin Microbiome ◽  
Microbial Infections ◽  
Pressure Injury ◽  
Long Time

Pressure injuries have been identified as one of the main health hazards among bedridden elderly people. Bedridden elderly people often stay in the same position for a long time, because they cannot switch positions; thus, the blood flow in the part of the body that is being compressed between the bed and their own weight is continuously blocked. As a result, redness and ulcers occur due to lacking oxygen and nutrients in the skin tissues, and these sites are often infected with microorganisms and, thus, become suppurative wounds, a condition commonly determined as pressure injuries. If left untreated, the pressure injury will recur with microbial infections, often resulting in cellulitis, osteomyelitis, and sepsis. The skin microbiome, in which many types of bacteria coexist, is formed on the skin surface. However, it remains unclear what characteristic of the skin microbiome among the bedridden elderly constitutes the development and severity of pressure injuries and the development of post-pressure injury infections. Thus, in this review article, we outlined the changes in the skin microbiome among the bedridden elderly people and their potential involvement in the onset and recurrence of pressure injuries.

scholarly journals Ageing and ocular problems

2021 ◽  
Author(s):  
Z. Z. Nagy ◽  
I. Kovács
Keyword(s):  
Elderly People ◽  
Computer Technology ◽  
Review Article ◽  
The Body ◽  
Average Life ◽  
Average Life Expectancy ◽  
Near Vision ◽  
New Methods ◽  
Ageing Processes ◽  
Human Kind

Abstract Ageing is a common problem in modern societies. Due to sophisticated new methods in medicine, the average life expectancy significantly increased in recent years. 70 is the new 50. The new principles of food intake and processing, more exercise, and less smoking contributed to a health benefits and a longer life span of human kind. Nevertheless, there are the special problems of ageing. Numerous dysfunctions of the body may arise affecting a broad range of organs and the musculoskeletal system. The eye can also be severely affected by ageing. Vision gained more importance recently especially during the COVID-19 pandemic. Elderly people who never used computers before, had to learn computer technology in order to communicate with their family and to accomplish their everyday tasks or pay their bills. Therefore, good near vision has become crucial for elderly people. In this review article the most common ageing problems of the eye, therapies and pathophysiology of ageing processes will be reviewed and discussed. There are physiological problems of ageing and there are ocular pathologies which can be treated efficiently in time to preserve near and far visual acuity.

Comparison of the thermoregulatory response of buffaloes and tropical cattle, using fluctuations in rectal temperature, skin temperature and haematocrit as an index

2004 ◽  
Vol 142 (3) ◽  
pp. 351-355 ◽  
Author(s):  
A. KOGA ◽  
M. SUGIYAMA ◽  
A. N. DEL BARRIO ◽  
R. M. LAPITAN ◽  
B. R. ARENDA ◽  
...  
Keyword(s):  
Blood Flow ◽  
Ambient Temperature ◽  
Skin Temperature ◽  
Correlation Coefficient ◽  
Rectal Temperature ◽  
Comparative Studies ◽  
Skin Surface ◽  
The Body ◽  
Thermoregulatory Response ◽  
Body Core

In previous comparative studies of buffaloes and temperate cattle, a greater increase in rectal temperature (RT) and skin temperature (ST), and a greater decrease in haematocrit (Ht) have been observed in buffaloes than in temperate cattle with an increase in ambient temperature (AT). Our series of previous experiments suggested that great changes in RT, ST and Ht are induced in buffaloes by a marked increase in blood flow from the body core to the surface, which accelerates dissipation of heat from the skin surface. On the basis of these suggestions, the present study was undertaken to compare fluctuations in RT, ST and Ht between buffaloes and tropical cattle. Fluctuations in the aforementioned parameters, particularly RT and Ht, were greater in buffaloes than in cattle. Moreover, the correlation for RT or Ht v. AT was significant for buffaloes (r=0·33 and −0·37, respectively) but not for cattle. The correlation coefficient for ST v. AT was significant in both species, but was greater in buffaloes (r=0·63) than in cattle (r=0·56). These results demonstrate that with changes in ambient temperature, RT, ST and Ht fluctuate much more in buffaloes than in tropical cattle, as found previously for temperate cattle. Therefore, the distinctive thermoregulatory responses of buffalo are confirmed as being specific to this species.

scholarly journals A Study on Skin Microbiome, Knowledge and Control of Malaria among Volunteers in Akure– A Malaria Endemic Area, South-West, Nigeria

2021 ◽  
pp. 45-58
Author(s):  
Omoya Funmilola Oluyemi ◽  
Adeleye Yemisi Mary
Keyword(s):  
Endemic Area ◽  
Mosquito Control ◽  
Skin Surface ◽  
Fungal Species ◽  
The Body ◽  
Skin Microbiome ◽  
South West ◽  
Microbiological Methods ◽  
Age Range ◽  
And Control

The study was carried out to determine the skin microbial diversity, knowledge and control of malaria among volunteers in Akure. Skin surface of one hundred and fourteen (114) consented participants were swabbed at different locations (elbow, neck, and knee) on the body and examined for the microbial diversities using standard microbiological methods. Socio-demographic characteristics, knowledge and awareness of malaria and mosquito control among the participants were evaluated with the use of multiple choice questioners. The highest number of the participant were within the age range 31-40 years 32(28.1%) followed by age range 11-20 and 21-30 years (17.5%). The number of male and female participants were 67(58.8%) and 47(41.2%) respectively. It was noted that all the participants have heard about malaria before while 60(52.6%) of them have been diagnosed of malaria in the last 6 months, 28.9% of the participants have their personal mosquito repellant as at the time of this investigation while 71.1% did not have mosquito repellant. Bacterial counts (Log10 CFU/cm2) ranged from 5.70±0.13 (neck) to 6.51±0.05 (knee) while the highest fungal counts (Log10 SFU/cm2) was observed in knee (2.80±0.07) followed by elbow (2.61±0.04) and neck (1.91±0.05). Ten (10) bacterial and nine (9) different fungal species were identified as skin microbiome, the most occurred bacterial genus in the skin of the neck, elbow and knee were Staphylococcus (49.36%), Bacillus (42.23%) and Staphylococcus (43.75%) respectively while the most occurred fungal genus were Aspergillus (36.54%), Aspergillus (50%) and Alternaria (18.92%) in the neck, elbow and knee skin respectively. The results of the study will be important for control of malaria in endemic area and the skin microflora isolated could be explored as mosquito repellant to reduce malaria infection in endemic areas.

COMPARISON OF ANTIHYPERTENSIVE EFFECT OF MOXONIDINE VERSUS CLONIDINE IN RENAL FAILURE PATIENTS.

2018 ◽  
Vol 6 (9) ◽  
Author(s):  
DR.MATHEW GEORGE ◽  
DR.LINCY JOSEPH ◽  
MRS.DEEPTHI MATHEW ◽  
ALISHA MARIA SHAJI ◽  
BIJI JOSEPH ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renal Failure ◽  
Blood Flow ◽  
Blood Vessel ◽  
Blood Vessels ◽  
High Blood Pressure ◽  
Antihypertensive Effect ◽  
The Body ◽  
Ability To Work ◽  
Blood Flows

Blood pressure is the force of blood pushing against blood vessel walls as the heart pumps out blood, and high blood pressure, also called hypertension, is an increase in the amount of force that blood places on blood vessels as it moves through the body. Factors that can increase this force include higher blood volume due to extra fluid in the blood and blood vessels that are narrow, stiff, or clogged(1). High blood pressure can damage blood vessels in the kidneys, reducing their ability to work properly. When the force of blood flow is high, blood vessels stretch so blood flows more easily. Eventually, this stretching scars and weakens blood vessels throughout the body, including those in the kidneys.

A Review on Post Pregnancy Healer Herbs

2019 ◽  
Vol 15 (2) ◽  
pp. 102-108 ◽  
Author(s):  
Rashmi Saxena Pal ◽  
Yogendra Pal ◽  
Pranay Wal
Keyword(s):  
Literature Search ◽  
Review Article ◽  
The Body ◽  
Medical Supervision ◽  
Areas Of Concern

Background: Postpartum is an important phase of life after childbirth. It needs to be highly important as in terms of health in future life. This time brings lots of complications with it. Lots of aspects need to be looked after as the care of the new mom is essential to bring back her stamina and strength. Objective: The objective of this review article is to explore the heeding power hidden in nature for returning back to the mothers to the pre-pregnancy state. There are various areas of concern after postpartum to heal up the body overall, such as to heal up the uterus, providing galactagogues, nutritives, maintenance of hormones and restoring back the strength and tone of the abdomen. Materials and Methods: A literature search has been done on the various herbs, which fulfill the various desired aspects to be looked after post pregnancy. Results: There are various herbs present in nature, regarding their hidden potential still the awareness is not up to the mark. This review highlights the various plants which have been proven to be useful in dealing the post-pregnancy issues. They deal with all the aspects of complications and issues occurring post pregnancy. They heal the uterus which has undergone so many types of changes, maintains the balance of hormones back, besides providing nutrition and increasing the production of milk, they also restore back the tone and strength of the walls of the abdomen. Conclusion: These herbs are full-fledged with the phytoconstituents that heal the whole system after delivery. The need of present time is to take patiently these as the source of medicines regularly under medical supervision to overcome the various concerned problems of post pregnancy.

scholarly journals Calculating the optimal hematocrit under the constraint of constant cardiac power

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Michal Sitina ◽  
Heiko Stark ◽  
Stefan Schuster
Keyword(s):  
Blood Flow ◽  
High Performance ◽  
Animal Species ◽  
Normal Values ◽  
Mechanical Load ◽  
The Body ◽  
Trade Off ◽  
Cardiac Power ◽  
Optimal Value ◽  
Good Agreement

AbstractIn humans and higher animals, a trade-off between sufficiently high erythrocyte concentrations to bind oxygen and sufficiently low blood viscosity to allow rapid blood flow has been achieved during evolution. Optimal hematocrit theory has been successful in predicting hematocrit (HCT) values of about 0.3–0.5, in very good agreement with the normal values observed for humans and many animal species. However, according to those calculations, the optimal value should be independent of the mechanical load of the body. This is in contradiction to the exertional increase in HCT observed in some animals called natural blood dopers and to the illegal practice of blood boosting in high-performance sports. Here, we present a novel calculation to predict the optimal HCT value under the constraint of constant cardiac power and compare it to the optimal value obtained for constant driving pressure. We show that the optimal HCT under constant power ranges from 0.5 to 0.7, in agreement with observed values in natural blood dopers at exertion. We use this result to explain the tendency to better exertional performance at an increased HCT.

scholarly journals Development of Novel Oral Formulations of Disulfide Antioxidants Based on Porous Silica for Controlled Release of the Drugs

Materials ◽  
2021 ◽  
Vol 14 (4) ◽  
pp. 963
Author(s):  
Ekaterina S. Dolinina ◽  
Elena V. Parfenyuk
Keyword(s):  
Antioxidant Activity ◽  
Surface Chemistry ◽  
Sol Gel ◽  
Porous Silica ◽  
The Body ◽  
Oral Drug ◽  
Therapeutic Concentration ◽  
Release Process ◽  
Zero Order Kinetics ◽  
Long Time

Powerful antioxidant α-lipoic acid (LA) exhibits limited therapeutic efficiency due to its pharmacokinetic properties. Therefore, the purpose of this work was to evaluate the ability of silica-based composites of LA as well as its amide (lipoamide, LM), as new oral drug formulations, to control their release and maintain their therapeutic concentration and antioxidant activity in the body over a long time. The composites synthesized at different sol–gel synthesis pH and based on silica matrixes with various surface chemistry were investigated. The release behavior of the composites in media mimicking pH of digestive fluids (pH 1.6, 6.8, and 7.4) was revealed. The effects of chemical structure of the antioxidants, synthesis pH, surface chemistry of the silica matrixes in the composites as well as the pH of release medium on kinetic parameters of the drug release and mechanisms of the process were discussed. The comparative analysis of the obtained data allowed the determination of the most promising composites. Using these composites, modeling of the release process of the antioxidants in accordance with transit conditions of the drugs in stomach, proximal, and distal parts of small intestine and colon was carried out. The composites exhibited the release close to the zero order kinetics and maintained the therapeutic concentration of the drugs and antioxidant effect in all parts of the intestine for up to 24 h. The obtained results showed that encapsulation of LA and LM in the silica matrixes is a promising way to improve their bioavailability and antioxidant activity.

scholarly journals Mangiferin as New Potential Anti-Cancer Agent and Mangiferin-Integrated Polymer Systems—A Novel Research Direction

Biomolecules ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 79
Author(s):  
Svetlana N. Morozkina ◽  
Thi Hong Nhung Vu ◽  
Yuliya E. Generalova ◽  
Petr P. Snetkov ◽  
Mayya V. Uspenskaya
Keyword(s):  
Molecular Mechanisms ◽  
Biological Activities ◽  
Research Direction ◽  
Biological Action ◽  
The Body ◽  
Biologically Active ◽  
Polymer Systems ◽  
Anti Cancer ◽  
Long Time ◽  
Cancer Agent

For a long time, the pharmaceutical industry focused on natural biologically active molecules due to their unique properties, availability and significantly less side-effects. Mangiferin is a naturally occurring C-glucosylxantone that has substantial potential for the treatment of various diseases thanks to its numerous biological activities. Many research studies have proven that mangiferin possesses antioxidant, anti-infection, anti-cancer, anti-diabetic, cardiovascular, neuroprotective properties and it also increases immunity. It is especially important that it has no toxicity. However, mangiferin is not being currently applied to clinical use because its oral bioavailability as well as its absorption in the body are too low. To improve the solubility, enhance the biological action and bioavailability, mangiferin integrated polymer systems have been developed. In this paper, we review molecular mechanisms of anti-cancer action as well as a number of designed polymer-mangiferin systems. Taking together, mangiferin is a very promising anti-cancer molecule with excellent properties and the absence of toxicity.

scholarly journals Acupuncture Affects Regional Blood Flow in Various Organs

2008 ◽  
Vol 5 (2) ◽  
pp. 145-151 ◽  
Author(s):  
Sae Uchida ◽  
Harumi Hotta
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
The Body ◽  
Neural Mechanisms ◽  
Uterine Blood Flow ◽  
Afferent Pathway ◽  
Antidromic Activation ◽  
Efferent Nerve ◽  
Afferent Nerves ◽  
Cortical Cerebral Blood Flow

In this review, our recent studies using anesthetized animals concerning the neural mechanisms of vasodilative effect of acupuncture-like stimulation in various organs are briefly summarized. Responses of cortical cerebral blood flow and uterine blood flow are characterized as non-segmental and segmental reflexes. Among acupuncture-like stimuli delivered to five different segmental areas of the body; afferent inputs to the brain stem (face) and to the spinal cord at the cervical (forepaw), thoracic (chest or abdomen), lumbar (hindpaw) and sacral (perineum) levels, cortical cerebral blood flow was increased by stimuli to face, forepaw and hindpaw. The afferent pathway of the responses is composed of somatic groups III and IV afferent nerves and whose efferent nerve pathway includes intrinsic cholinergic vasodilators originating in the basal forebrain. Uterine blood flow was increased by cutaneous stimulation of the hindpaw and perineal area, with perineal predominance. The afferent pathway of the response is composed of somatic group II, III and IV afferent nerves and the efferent nerve pathway includes the pelvic parasympathetic cholinergic vasodilator nerves. Furthermore, we briefly summarize vasodilative regulation of skeletal muscle blood flow via a calcitonin gene-related peptide (CGRP) induced by antidromic activation of group IV somatic afferent nerves. These findings in healthy but anesthetized animals may be applicable to understanding the neural mechanisms improving blood flow in various organs following clinical acupuncture.

scholarly journals Chinese Herbal Medicine Alleviates Thyroidectomy-Induced Cardiopulmonary Exercise Dysfunction in Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Tai-Yuan Chuang ◽  
Chia-Ying Lien ◽  
Chih-Hsiang Hsu ◽  
Chen-Wen Lu ◽  
Chung-Hsin Wu
Keyword(s):  
Blood Flow ◽  
Body Weight ◽  
Negative Control ◽  
The Body ◽  
Male Rats ◽  
Free Triiodothyronine ◽  
Cardiopulmonary Exercise ◽  
Chinese Herbal ◽  
Subcutaneous Blood Flow ◽  
Tsh Levels

Hypothyroidism frequently causes cardiopulmonary dysfunction, such as heart failure and respiratory and metabolic deficiencies. This study investigated the effects of Chinese herbal formula B307 on thyroidectomy-induced cardiopulmonary exercise dysfunction in rats. Twenty male rats were equally divided into four groups: negative control with sham treatment, positive control with oral B307 treatment only, thyroidectomy treatment only, and thyroidectomy with B307 posttreatment groups. The feeding dose of B307 was 50 mg/kg per day for 14 days. We examined and then compared the thyroid-stimulating hormone (TSH), free triiodothyronine (T3), free thyroxine (T4), and reactive oxygen species (ROS) from the blood of these four groups. Also, we compared the body weight, neck subcutaneous blood flow, cardiac ejection function, cardiopulmonary exercise function of oxygen consumption (VO2), carbon dioxide production (VCO2), and respiratory quotient (RQ = VCO2/VO2) among the four groups. Our results indicated that thyroidectomized rats had significantly decreased body weight, neck subcutaneous blood flow, cardiac ejection function, serum T3 and T4, and VO2 and VCO2, but had significantly increased ROS and TSH levels and RQ values compared with sham rats (P<0.01–0.05). In addition, thyroidectomized rats receiving oral B307 treatment had significantly increased body weight, neck subcutaneous blood flow, cardiac ejection function, and VO2, but significantly decreased ROS and TSH levels and VCO2 and RQ values compared with thyroidectomized rats (P<0.01–0.05). We suggest that the B307 could be a protective and beneficial alternative treatment for thyroidectomy-induced cardiopulmonary exercise dysfunction.

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