scholarly journals Correction: Szopinska-Tokov et al. Investigating the Gut Microbiota Composition of Individuals with Attention-Deficit/Hyperactivity Disorder and Association with Symptoms. Microorganisms 2020, 8, 406

2021 ◽  
Vol 9 (7) ◽  
pp. 1358
Author(s):  
Joanna Szopinska-Tokov ◽  
Sarita Dam ◽  
Jilly Naaijen ◽  
Prokopis Konstanti ◽  
Nanda Rommelse ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Gut Microbiota ◽  
Attention Deficit ◽  
Microbiota Composition ◽  
Hyperactivity Disorder ◽  
Gut Microbiota Composition

The authors wish to make the following correction to this paper [...]

scholarly journals Investigating the Gut Microbiota Composition of Individuals with Attention-Deficit/Hyperactivity Disorder and Association with Symptoms

2020 ◽  
Author(s):  
Joanna Szopinska-Tokov ◽  
Sarita Dam ◽  
Jilly Naaijen ◽  
Prokopis Konstanti ◽  
Nanda Rommelse ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Gut Microbiota ◽  
Attention Deficit ◽  
Multiple Testing ◽  
Neurodevelopmental Disorder ◽  
Microbiota Composition ◽  
Multiple Testing Correction ◽  
Hyperactivity Disorder ◽  
Gut Microbiota Composition

Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder. Given the growing evidence of gut microbiota being involved in psychiatric (including neurodevelopmental) disorders, we aimed to identify differences in gut microbiota composition between participants with ADHD and controls and to investigate the role of the microbiota in inattention and hyperactivity/impulsivity. Fecal samples were collected from 107 participants (NADHD=42; Ncontrols=50; NsubthreholdADHD=15; range age: 13-29 years). The relative quantification of bacterial taxa was done using 16S ribosomal RNA gene amplicon sequencing. Beta-diversity revealed significant differences in bacterial composition between participants with ADHD and healthy controls, which was also significant for inattention, but showing a trend in case of hyperactivity/impulsivity only. Ten genera showed nominal differences (P < 0.05) between both groups, of which seven genera were tested for their association with ADHD symptom scores (adjusting for age, sex, body mass index, time delay between feces collection and symptoms assessment, medication use and family relatedness). Our results show that variation of a genus from the Ruminococcaceae family (Ruminococcaceae_UCG_004) is associated (after multiple testing correction) with inattention symptoms, and suggest a role of gut microbiota in ADHD pathophysiology.

scholarly journals Investigating the Gut Microbiota Composition of Individuals with Attention-Deficit/Hyperactivity Disorder and Association with Symptoms

2020 ◽  
Vol 8 (3) ◽  
pp. 406 ◽  
Author(s):  
Joanna Szopinska-Tokov ◽  
Sarita Dam ◽  
Jilly Naaijen ◽  
Prokopis Konstanti ◽  
Nanda Rommelse ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Gut Microbiota ◽  
Attention Deficit ◽  
Multiple Testing ◽  
Neurodevelopmental Disorder ◽  
Microbiota Composition ◽  
Multiple Testing Correction ◽  
Hyperactivity Disorder ◽  
Gut Microbiota Composition

Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder. Given the growing evidence of gut microbiota being involved in psychiatric (including neurodevelopmental) disorders, we aimed to identify differences in gut microbiota composition between participants with ADHD and controls and to investigate the role of the microbiota in inattention and hyperactivity/impulsivity. Fecal samples were collected from 107 participants (NADHD = 42; Ncontrols = 50; NsubthreholdADHD = 15; range age: 13–29 years). The relative quantification of bacterial taxa was done using 16S ribosomal RNA gene amplicon sequencing. Beta-diversity revealed significant differences in bacterial composition between participants with ADHD and healthy controls, which was also significant for inattention, but showing a trend in case of hyperactivity/impulsivity only. Ten genera showed nominal differences (p < 0.05) between both groups, of which seven genera were tested for their association with ADHD symptom scores (adjusting for age, sex, body mass index, time delay between feces collection and symptoms assessment, medication use, and family relatedness). Our results show that variation of a genus from the Ruminococcaceae family (Ruminococcaceae_UCG_004) is associated (after multiple testing correction) with inattention symptoms and support the potential role of gut microbiota in ADHD pathophysiology.

Gut microbiota and dietary patterns in children with attention-deficit/hyperactivity disorder

2019 ◽  
Vol 29 (3) ◽  
pp. 287-297 ◽  
Author(s):  
Liang-Jen Wang ◽  
Chia-Yu Yang ◽  
Wen-Jiun Chou ◽  
Min-Jing Lee ◽  
Miao-Chun Chou ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Gut Microbiota ◽  
Dietary Patterns ◽  
Attention Deficit ◽  
Hyperactivity Disorder

scholarly journals Gut microbiota from persons with attention-deficit/hyperactivity disorder affects the brain in mice

Microbiome ◽  
2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Anouk C. Tengeler ◽  
Sarita A. Dam ◽  
Maximilian Wiesmann ◽  
Jilly Naaijen ◽  
Miranda van Bodegom ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Gut Microbiota ◽  
Attention Deficit ◽  
Hyperactivity Disorder ◽  
The Brain

Gut microbiota and attention deficit hyperactivity disorder: new perspectives for a challenging condition

2017 ◽  
Vol 26 (9) ◽  
pp. 1081-1092 ◽  
Author(s):  
María Carmen Cenit ◽  
Isabel Campillo Nuevo ◽  
Pilar Codoñer-Franch ◽  
Timothy G. Dinan ◽  
Yolanda Sanz
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Gut Microbiota ◽  
Attention Deficit ◽  
Hyperactivity Disorder

scholarly journals Gut microbiota profiles of autism spectrum disorder and attention deficit/hyperactivity disorder: A systematic literature review.

Gut Microbes ◽  
2020 ◽  
Vol 11 (5) ◽  
pp. 1172-1187 ◽  
Author(s):  
Caspar Bundgaard-Nielsen ◽  
Julie Knudsen ◽  
Peter D. C. Leutscher ◽  
Marlene B. Lauritsen ◽  
Mette Nyegaard ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Attention Deficit Hyperactivity Disorder ◽  
Literature Review ◽  
Gut Microbiota ◽  
Systematic Literature Review ◽  
Attention Deficit ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Hyperactivity Disorder

scholarly journals Gut microbiota signature in treatment-naïve attention-deficit/hyperactivity disorder

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Vanesa Richarte ◽  
Cristina Sánchez-Mora ◽  
Montserrat Corrales ◽  
Christian Fadeuilhe ◽  
Laura Vilar-Ribó ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Gut Microbiota ◽  
Relative Abundance ◽  
Attention Deficit ◽  
Gut Microbiome ◽  
Rating Scale ◽  
Small Sample ◽  
Adhd Group ◽  
Healthy Controls ◽  
Hyperactivity Disorder

AbstractCompelling evidence supports alterations in gut microbial diversity, bacterial composition, and/or relative abundance of several bacterial taxa in attention-deficit/hyperactivity disorder (ADHD). However, findings for ADHD are inconsistent among studies, and specific gut microbiome signatures for the disorder remain unknown. Given that previous studies have mainly focused on the pediatric form of the disorder and involved small sample sizes, we conducted the largest study to date to compare the gastrointestinal microbiome composition in 100 medication-naïve adults with ADHD and 100 sex-matched healthy controls. We found evidence that ADHD subjects have differences in the relative abundance of several microbial taxa. At the family level, our data support a lower relative abundance of Gracilibacteraceae and higher levels of Selenomonadaceae and Veillonellaceae in adults with ADHD. In addition, the ADHD group showed higher levels of Dialister and Megamonas and lower abundance of Anaerotaenia and Gracilibacter at the genus level. All four selected genera explained 15% of the variance of ADHD, and this microbial signature achieved an overall sensitivity of 74% and a specificity of 71% for distinguishing between ADHD patients and healthy controls. We also tested whether the selected genera correlate with age, body mass index (BMI), or scores of the ADHD rating scale but found no evidence of correlation between genera relative abundance and any of the selected traits. These results are in line with recent studies supporting gut microbiome alterations in neurodevelopment disorders, but further studies are needed to elucidate the role of the gut microbiota on the ADHD across the lifespan and its contribution to the persistence of the disorder from childhood to adulthood.

Gut microbiota profiles in treatment-naïve children with attention deficit hyperactivity disorder

2018 ◽  
Vol 347 ◽  
pp. 408-413 ◽  
Author(s):  
Hai-yin Jiang ◽  
Yuan-yue Zhou ◽  
Guo-ling Zhou ◽  
Yu-chuan Li ◽  
Jing Yuan ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Gut Microbiota ◽  
Attention Deficit ◽  
Hyperactivity Disorder ◽  
Treatment Naïve

scholarly journals Systematic review of gut microbiota and attention-deficit hyperactivity disorder (ADHD)

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Alverina Cynthia Sukmajaya ◽  
Maria Inge Lusida ◽  
Soetjipto ◽  
Yunias Setiawati
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Gut Microbiota ◽  
Inflammatory Cytokines ◽  
Attention Deficit ◽  
Healthy Individuals ◽  
Case Control Studies ◽  
Cultural Aspects ◽  
Hyperactivity Disorder ◽  
High Level ◽  
Pro Inflammatory Cytokines

Abstract Background Gut–brain axis (GBA) is a system widely studied nowadays, especially in the neuropsychiatry field. It is postulated to correlate with many psychiatric conditions, one of them being attention-deficit hyperactivity disorder (ADHD). ADHD is a disorder that affects many aspects of life, including but not limited to financial, psychosocial, and cultural aspects. Multiple studies have made a comparison of the gut microbiota between ADHD and healthy controls. Our aims were to review the existing studies analyzing the gut microbiota between human samples in ADHD and healthy individuals. Methods The literature was obtained using Google Scholar, Pubmed, and Science Direct search engine. The keywords used were “ADHD”, “gut microbiota”, “stool”, “gut”, and “microbiota”. The selected studies were all case–control studies, which identify the gut microbiota between ADHD and healthy individuals. Result We found six studies which were eligible for review. The model and methods of each study is different. Forty-nine bacterial taxa were found, yet none of them can explain the precise relationship between ADHD and the gut microbiota. Bifidobacterium was found in higher amount in ADHD patients, but other study stated that the abundance of this genus was lower in ADHD with post-micronutrient treatment. This may suggest that micronutrient can modulate the population of Bifidobacterium and improve the behavior of ADHD patients. Other notable findings include a significantly lower population of Dialister in unmedicated ADHD, which rose after patients were medicated. A smaller amount of Faecalibacterium were also found in ADHD patients. This may explain the pathogenesis of ADHD, as Faecalibacterium is known for its anti-inflammatory products. It is possible the scarcity of this genera could induce overproduction of pro-inflammatory cytokines, which is in accordance with the high level of pro-inflammatory cytokines found in children with ADHD. Conclusion There were no studies that examined which bacterial taxa correlated most to ADHD. This might occur due to the different model and methods in each study. Further study is needed to identify the correlation between gut microbiota and ADHD.

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