scholarly journals Epidemiology and Characterization of CTX-M-55-Type Extended-Spectrum β-Lactamase-Producing Salmonella enterica Serovar Enteritidis Isolated from Patients in Shanghai, China

2021 ◽  
Vol 9 (2) ◽  
pp. 260
Author(s):  
Chenyang Cao ◽  
Qinya Niu ◽  
Jia Chen ◽  
Xuebin Xu ◽  
Huanjing Sheng ◽  
...  
Keyword(s):  
High Frequency ◽  
Salmonella Enterica ◽  
Genetic Similarity ◽  
Multidrug Resistant ◽  
Salmonella Enterica Serovar Enteritidis ◽  
Salmonella Infections ◽  
Extended Spectrum ◽  
Encoding Genes ◽  
High Genetic Similarity

The emergence of extended-spectrum β-lactamase-producing Salmonella enterica serovar Enteritidis (ESBL-SE) in humans and foods has gained global attention. In particular, CTX-M-type ESBL-SE are increasingly being detected from various sample types. The aim of this study was to comprehensively analyze the epidemiology and characteristics of blaCTX-M-55-carrying ESBL-SE isolates of clinical origin in Shanghai, China. A total of 292 S. Enteritidis isolates were recovered from the feces and blood of outpatients and inpatients between 2006 and 2014. Overall, there was a high frequency of cefotaxime-resistant isolates (97.3%), which was significantly higher (p < 0.01) than that of isolates resistant to the other tested antibiotics. All S. Enteritidis isolates exhibited resistance to ≥1 antibiotic, and 98.0% were multidrug resistant. A total of 233 isolates were identified as ESBL-SE, 166 of which were CTX-M type. Six subtypes of CTX-M-encoding genes were detected, among which blaCTX-M-55 (91.6%, 152/166) was the most prevalent genotype. There was high genetic similarity among blaCTX-M-55-positive ESBL-SE. The blaCTX-M-55 gene in the ESBL-SE donor strains could be easily transferred into Enterobacteriaceae recipient strains. This study highlights that CTX-M-55 should be considered an important surveillance target in Shanghai, China. Cephalosporins, especially cefotaxime, must be used with caution in empirical treatment for Salmonella infections.

Genotypic and epidemiologic characterization of extended-spectrum cephalosporin resistant Salmonella enterica from US beef feedlots

2017 ◽  
Vol 146 ◽  
pp. 143-149 ◽  
Author(s):  
D.F. Mollenkopf ◽  
D.A. Mathys ◽  
D.A. Dargatz ◽  
M.M. Erdman ◽  
G.G. Habing ◽  
...  
Keyword(s):  
Salmonella Enterica ◽  
Extended Spectrum ◽  
Beef Feedlots

Characterization of SEN3800-associated virulence of Salmonella enterica serovar Enteritidis phage type 8

2014 ◽  
Vol 65 (2) ◽  
pp. 631-637
Author(s):  
Daniel C. Shippy ◽  
Nicholas M. Eakley ◽  
Dareen M. Mikheil ◽  
Anna De La Cotera ◽  
Amin A. Fadl
Keyword(s):  
Salmonella Enterica ◽  
Phage Type ◽  
Salmonella Enterica Serovar Enteritidis

scholarly journals Prevalence of Extended-Spectrum β-Lactamases in E. coli of Rats in the Region North East of Gabon

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Richard Onanga ◽  
Pierre Philippe Mbehang Nguema ◽  
Guy Roger Ndong Atome ◽  
Arsène Mabika Mabika ◽  
Berthelemy Ngoubangoye ◽  
...  
Keyword(s):  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Extended Spectrum Beta Lactamase ◽  
E Coli ◽  
North East ◽  
Molecular Tests ◽  
Extended Spectrum ◽  
Susceptibility Tests ◽  
Animal Feces

Antibiotic resistance occurs in the environment by multiplication and the spread of multidrug-resistant bacteria that would be due to an improper and incorrect use of antibiotics in human and veterinary medicine. The aim of this study was to establish the prevalence of E.coli producing Extended-Spectrum beta-Lactamase (ESBL) antibiotics from rats and gregarious animals in a semirural area of Gabon and to evaluate the origin of a resistance distribution in the environment from animal feces. The bacterial culture was carried out, and the identification of E. coli strains on a specific medium and the antibiotic susceptibility tests allowed establishing the prevalence. Characterization of resistance genes was performed by gene amplification after DNA extraction. On 161 feces collected in rats, 32 strains were isolated, and 11 strains of E. coli produced ESBL with a prevalence of 34.37%. Molecular tests showed that CTX-M genes 214 bp were identified in rats. The presence of CTX-M genes could have a human origin. So, the rats can carry ESBL-producing Enterobacteriaceae which poses a risk to human health and pets in this region of Gabon.

scholarly journals Characterization of Chicken Spleen Transcriptome after Infection with Salmonella enterica Serovar Enteritidis

PLoS ONE ◽  
2012 ◽  
Vol 7 (10) ◽  
pp. e48101 ◽  
Author(s):  
Marta Matulova ◽  
Jana Rajova ◽  
Lenka Vlasatikova ◽  
Jiri Volf ◽  
Hana Stepanova ◽  
...  
Keyword(s):  
Salmonella Enterica ◽  
Salmonella Enterica Serovar Enteritidis ◽  
Chicken Spleen

scholarly journals Molecular characterization of extended-spectrum beta-lactamase producing Enterobacteriaceae in a Saudi Arabian tertiary hospital

2014 ◽  
Vol 8 (03) ◽  
pp. 282-288 ◽  
Author(s):  
Hoda Hassan ◽  
Baha Abdalhamid
Keyword(s):  
Tertiary Hospital ◽  
Multidrug Resistant ◽  
Beta Lactamase ◽  
M Gene ◽  
Extended Spectrum Beta Lactamase ◽  
E Coli ◽  
Extended Spectrum ◽  
Vitek 2 ◽  
High Level

Introduction: The aim of this study was to determine the prevalence of extended-spectrum beta-lactamase (ESBL) producing Escherichia coli (E. coli), Klebsiella pneumoniae (K. pneumoniae), and Proteus mirabilis (P. mirabilis). In addition, different methods for detection of these enzymes, including the newly introduced CHROMagar ESBL, were evaluated. Methodology: A total of 382 Enterobacteriaceae clinical isolates were obtained from King Fahad Specialist Hospital – Dammam, during 2011 and screened for production of ESBL using advanced expert system of Vitek 2, CHROMagar and ESBL-E-strips. PCR assay was used to detect blaTEM, blaSHV, and blaCTX-M genes. Susceptibility to a panel of antibiotics was determined. Results: The overall proportion of ESBL-producing enterobacterial isolates was 30.6%, which was higher in E. coli (35.8%) than in K. pneumoniae (25.7%). ESBL genotypes showed remarkable increase in the CTX-M (97.4%) compared to SHV (23.1%). The predominant ESBL was CTX-M- 15 (92.1 %). No TEM ESBL was detected in this study. The Vitek2 showed the highest sensitivity (100%), and the CHROMagar had the lowest specificity (97.3%) compared to the molecular method. All isolates were susceptible to imipenem and meropenem. Conclusions: This study confirms a high level of blaCTX-M positive ESBL isolates are circulating in the Eastern Province of Saudi Arabia. The trend of a multidrug-resistant profile associated with the recovery of the blaCTX-M gene is alarming.

scholarly journals Characterization of the emerging multidrug-resistant Salmonella enterica serovar Indiana strains in China

2019 ◽  
Vol 8 (1) ◽  
pp. 29-39 ◽  
Author(s):  
Jiansen Gong ◽  
Ximin Zeng ◽  
Ping Zhang ◽  
Di Zhang ◽  
Chengming Wang ◽  
...  
Keyword(s):  
Salmonella Enterica ◽  
Multidrug Resistant

scholarly journals Genomic Characterization of Extended-Spectrum Cephalosporin-Resistant Salmonella enterica in the Colombian Poultry Chain

2018 ◽  
Vol 9 ◽  
Author(s):  
Luis Ricardo Castellanos ◽  
Linda van der Graaf-van Bloois ◽  
Pilar Donado-Godoy ◽  
Maribel León ◽  
Viviana Clavijo ◽  
...  
Keyword(s):  
Salmonella Enterica ◽  
Extended Spectrum ◽  
Genomic Characterization
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