scholarly journals Detection of Epstein–Barr Virus in Periodontitis: A Review of Methodological Approaches

2020 ◽  
Vol 9 (1) ◽  
pp. 72
Author(s):  
Lilit Tonoyan ◽  
Marlène Chevalier ◽  
Séverine Vincent-Bugnas ◽  
Robert Marsault ◽  
Alain Doglio
Keyword(s):  
Oral Health ◽  
Epstein Barr Virus ◽  
Chronic Inflammatory Disease ◽  
Systemic Diseases ◽  
New Paradigm ◽  
Barr Virus ◽  
Gamma Herpesvirus ◽  
Epstein Barr ◽  
Detection And Diagnosis

Periodontitis, an inflammatory condition that affects the structures surrounding the tooth eventually leading to tooth loss, is one of the two biggest threats to oral health. Beyond oral health, it is associated with systemic diseases and even with cancer risk. Obviously, periodontitis represents a major global health problem with significant social and economic impact. Recently, a new paradigm was proposed in the etiopathogenesis of periodontitis involving a herpesviral–bacterial combination to promote long-term chronic inflammatory disease. Periodontitis as a risk factor for other systemic diseases can also be better explained based on viral–bacterial etiology. Significant efforts have brought numerous advances in revealing the links between periodontitis and Epstein–Barr virus (EBV), a gamma herpesvirus ubiquitous in the adult human population. The strong evidence from these studies may contribute to the advancement of periodontitis research and the ultimate control of the disease. Advancing the periodontitis research will require implementing suitable methods to establish EBV involvement in periodontitis. This review evaluates and summarizes the existing methods that allow the detection and diagnosis of EBV in periodontitis (also applicable in a more general way to other EBV-related diseases), and discusses the feasibility of the application of innovative emerging technologies.

scholarly journals Epstein–Barr virus load is higher in long‐term Hodgkin lymphoma survivors compared to their unaffected twins and unrelated controls

2018 ◽  
Vol 185 (2) ◽  
pp. 377-380 ◽  
Author(s):  
Amie E. Hwang ◽  
Vickie Marshall ◽  
David V. Conti ◽  
Bharat N. Nathwani ◽  
Thomas M. Mack ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Epstein Barr Virus ◽  
Virus Load ◽  
Barr Virus ◽  
Epstein Barr ◽  
Lymphoma Survivors

scholarly journals How Does Epstein–Barr Virus Contribute to Chronic Periodontitis?

2020 ◽  
Vol 21 (6) ◽  
pp. 1940 ◽  
Author(s):  
Kenichi Imai ◽  
Yorimasa Ogata
Keyword(s):  
Diabetes Mellitus ◽  
Chronic Periodontitis ◽  
Epstein Barr Virus ◽  
Systemic Diseases ◽  
Periodontopathic Bacteria ◽  
Barr Virus ◽  
The World ◽  
Latently Infected ◽  
Plaque Control ◽  
Epstein Barr

Chronic periodontitis is spreading worldwide and mutually interacts with systemic diseases like diabetes mellitus. Although periodontopathic bacteria are inevitable pathogens in their onset and progression, many cases are not ascribable to the virulence of these bacteria because the effect of plaque control is limited. In contrast, Epstein–Barr virus (EBV) in the periodontium has been correlated with chronic periodontitis and has recently been considered as a promising pathogenic candidate for this disease. However, several important questions have yet to be addressed. For instance, although EBV latently infects more than 90% of individuals over the world, why do patients with chronic periodontitis exclusively harbor progeny EBV in the oral cavity? In addition, how does latently infected or reactivated EBV in the periodontium relate to the onset or progression of chronic periodontitis? Finally, is periodontitis incurable because EBV is the pathogen for chronic periodontitis? In this review, we attempt to answer these questions by reporting the current understanding of molecular relations and mechanisms between periodontopathic bacteria and EBV reactivation in the context of how this relationship may pertain to the etiology of chronic periodontitis.

Epstein–Barr virus associated CNS lymphoproliferative disorder after long-term immunosuppression

2019 ◽  
pp. practneurol-2019-002356 ◽  
Author(s):  
Andrew Lee ◽  
Leslie R Bridges ◽  
Mark Lloyd ◽  
Robert Barker ◽  
Damian R Wren ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Lymphoproliferative Disorder ◽  
Epstein Barr Virus ◽  
Lymphoproliferative Disorders ◽  
Postmortem Brain ◽  
Barr Virus ◽  
Epstein Barr ◽  
High Index Of Suspicion ◽  
Immunomodulatory Therapies

The incidence of Epstein–Barr virus (EBV)associated lymphoproliferative disorders has increased with greater use of immunomodulatory therapies. We present a woman who developed subacute cognitive decline and unilateral weakness while taking long-term mycophenolate mofetil for granulomatosis with polyangiitis; her postmortem brain histopathology confirmed an EBV-driven lymphoproliferative disorder. Clinicians must have a high index of suspicion for EBV-driven lymphoma in people taking long-term immunosuppression who develop new neurological problems. We review the role of mycophenolate mofetil in EBV-driven lymphoproliferative disorders, and discuss checking EBV status in all patients starting immunosuppression and in older people already taking immunosuppression.

Hemophagocytic lymphohistiocytosis due to germline mutations inSH2D1A, the X-linked lymphoproliferative disease gene

Blood ◽  
2001 ◽  
Vol 97 (4) ◽  
pp. 1131-1133 ◽  
Author(s):  
Maurizio Arico ◽  
Shinsaku Imashuku ◽  
Rita Clementi ◽  
Shigeyoshi Hibi ◽  
Tomoko Teramura ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Disease Gene ◽  
Gene Mutations ◽  
Lymphoproliferative Disease ◽  
Sh2 Domain ◽  
Barr Virus ◽  
Strong Resemblance ◽  
Male Patients ◽  
Epstein Barr

Abstract The hemophagocytic lymphohistiocytoses (HLH) comprise a heterogeneous group of disorders characterized by dysregulated activation of T cells and macrophages. Although some patients with HLH harbor perforin gene mutations, the cause of the remaining cases is not known. The phenotype of HLH bears a strong resemblance to X-linked lymphoproliferative disease (XLP), an Epstein-Barr virus (EBV)-associated immunodeficiency resulting from defects in SH2D1A, a small SH2 domain-containing protein expressed in T lymphocytes and natural killer cells. Here it is shown that 4 of 25 male patients with HLH who were examined harbored germline SH2D1A mutations. Among these 4 patients, only 2 had family histories consistent with XLP. On the basis of these findings, it is suggested that all male patients with EBV-associated hemophagocytosis be screened for mutations in SH2D1A. Patients identified as having XLP should undergo genetic counseling, and be followed long-term for development of lymphoma and hypogammaglobulinemia.

EPSTEIN-BARR VIRUS-NEGATIVE LYMPHOPROLIFERATIVE DISORDERS IN LONG-TERM SURVIVORS AFTER HEART, KIDNEY, AND LIVER TRANSPLANT1

2000 ◽  
pp. 827-833 ◽  
Author(s):  
Gianpietro Dotti ◽  
Roberto Fiocchi ◽  
Teresio Motta ◽  
Amando Gamba ◽  
Eliana Gotti ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Lymphoproliferative Disorders ◽  
Barr Virus ◽  
Epstein Barr ◽  
Long Term Survivors
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