scholarly journals Roles of Macrophage Migration Inhibitory Factor in Dengue Pathogenesis: From Pathogenic Factor to Therapeutic Target

2020 ◽  
Vol 8 (6) ◽  
pp. 891
Author(s):  
Yen-Chung Lai ◽  
Chiao-Hsuan Chao ◽  
Trai-Ming Yeh
Keyword(s):  
Migration Inhibitory Factor ◽  
Therapeutic Target ◽  
Macrophage Migration Inhibitory Factor ◽  
Critical Factor ◽  
Hemorrhagic Fever ◽  
Denv Infection ◽  
Inhibitory Factor ◽  
Severe Dengue ◽  
Macrophage Migration ◽  
Dengue Disease

Dengue virus (DENV) infection is the most prevalent mosquito-borne viral infection and can lead to severe dengue hemorrhagic fever (DHF) and even life-threatening dengue shock syndrome (DSS). Although the cytokine storm has been revealed as a critical factor in dengue disease, the limited understanding of dengue immunopathogenesis hinders the development of effective treatments. Macrophage migration inhibitory factor (MIF) is a pleiotropic proinflammatory cytokine that mediates diverse immune responses, and the serum level of MIF positively correlates with disease severity in patients with dengue. MIF is involved in DENV replication and many pathological changes, such as vascular leakage, during DENV infection. In this paper, the pathogenic roles of MIF and the regulation of MIF secretion during DENV infection are reviewed. Furthermore, whether MIF is a potential therapeutic target against DENV infection is also discussed.

scholarly journals Pathogenic Roles of Macrophage Migration Inhibitory Factor during Dengue Virus Infection

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Yung-Chun Chuang ◽  
Hong-Ru Chen ◽  
Trai-Ming Yeh
Keyword(s):  
Dengue Virus ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Immune Cell ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Denv Infection ◽  
Inhibitory Factor ◽  
Macrophage Migration ◽  
Knock Out

Dengue virus (DENV) infection is the most common cause of viral hemorrhagic fever, which can lead to life-threatening dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). Hemorrhage and plasma leakage are two major hallmarks of DHF/DSS. Because the mechanisms causing these pathogenic changes are unclear, there is no effective therapy against DHF/DSS. In this review, we focus on the possible pathogenic effects of a pleiotropic cytokine, macrophage migration inhibitory factor (MIF), on the pathogenesis of DENV infection. MIF is a critical mediator of the host immune response and inflammation, and there is a correlation between the serum levels of MIF and disease severity in dengue patients. Furthermore, MIF knock-out mice exhibit less severe clinical disease and lethality. However, the role of MIF in the pathogenesis of DHF/DSS is not limited to immune cell recruitment. Recent evidence indicates that DENV infection induced MIF production and may contribute to vascular hyperpermeability and viral replication during DENV infection. The expression of both adhesion and coagulation molecules on MIF-stimulated monocytes and endothelial cells is also increased, which may contribute to inflammatory and anticoagulatory states during DHF/DSS. Therefore, blocking MIF production or its function may provide a solution for the treatment and prevention of DHF/DSS.

scholarly journals Macrophage migration inhibitory factor - a therapeutic target in gallbladder cancer

BMC Cancer ◽  
2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Tejaswini Subbannayya ◽  
Pamela Leal-Rojas ◽  
Mustafa A. Barbhuiya ◽  
Remya Raja ◽  
Santosh Renuse ◽  
...  
Keyword(s):  
Gallbladder Cancer ◽  
Migration Inhibitory Factor ◽  
Therapeutic Target ◽  
Macrophage Migration Inhibitory Factor ◽  
Inhibitory Factor ◽  
Macrophage Migration
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