scholarly journals Automatic Detection of Granuloma Necrosis in Pulmonary Tuberculosis Using a Two-Phase Algorithm: 2D-TB

2019 ◽  
Vol 7 (12) ◽  
pp. 661
Author(s):  
Pelin Kus ◽  
Metin N. Gurcan ◽  
Gillian Beamer

Granuloma necrosis occurs in hosts susceptible to pathogenic mycobacteria and is a diagnostic visual feature of pulmonary tuberculosis (TB) in humans and in super-susceptible Diversity Outbred (DO) mice infected with Mycobacterium tuberculosis. Currently, no published automated algorithms can detect granuloma necrosis in pulmonary TB. However, such a method could reduce variability, and transform visual patterns into quantitative data for statistical and machine learning analyses. Here, we used histopathological images from super-susceptible DO mice to train, validate, and performance test an algorithm to detect regions of cell-poor necrosis. The algorithm, named 2D-TB, works on 2-dimensional histopathological images in 2 phases. In phase 1, granulomas are detected following background elimination. In phase 2, 2D-TB searches within granulomas for regions of cell-poor necrosis. We used 8 lung sections from 8 different super-susceptible DO mice for training and 10-fold cross validation. We used 13 new lung sections from 10 different super-susceptible DO mice for performance testing. 2D-TB reached 100.0% sensitivity and 91.8% positive prediction value. Compared to an expert pathologist, agreement was 95.5% and there was a statistically significant positive correlation for area detected by 2D-TB and the pathologist. These results show the development, validation, and accurate performance of 2D-TB to detect granuloma necrosis.

2021 ◽  
Vol 14 (2) ◽  
pp. 65-75
Author(s):  
Aprilia Dila Wardiningrum ◽  
Agus Dharmawan ◽  
Soni Sisbudi Harsono ◽  
Siswoyo Soekarno

Abstrak. Penelitian ini bertujuan untuk mengembangkan mesin pembersih dan pengayak tipe grizzly untuk beras sekaligus menguji kinerja mesin. Penelitian terdiri atas perancangan, perakitan, dan evaluasi kinerja mesin. Mesin yang dikembangkan memiliki 6 (enam) komponen utama, yaitu sumber dan transmisi tenaga putar, lubang pemasukan, unit pembersih beras, unit pengayak beras, lubang pengeluaran, dan kerangka mesin. Penelitian dilakukan menggunakan 3 (tiga) percobaan putaran, L (lambat), S (sedang), dan C (cepat) untuk mendapatkan data dari parameter pengukuran seperti kapasitas kerja, kecepatan putar mesin, laju isapan udara pada unit pembersih, slip putaran puli, dan persentase kehilangan bahan. Pada percobaan putaran L-S-C, yaitu 1654, 1817, dan 1979 rpm, menghasilkan laju isapan udara adalah 7,04, 7,79, dan 8,50 m/s. Slip putaran puli terjadi pada pulli 4 dengan nilai 3,27% tanpa sampal dan 1,70% dengan sampel; puli ini bertugas untuk menggetarkan ayakan grizzly 10-mesh. Kapasitas kerja pada 3 percobaan putaran (L-S-C) berturut-turut adalah 78,5, 81,6 dan 146,7 kg/jam. Pemisahan optimal dedak terjadi para percobaan putaran C sendangkan pemisahan menir terjadi pada percobaan L. Persentase kehilangan bahan tertinggi terjadi selama terjadi penurunan kecepatan putar yang mengakibatkan penurunan efektivitas kerja mesin.Design and Performance Test of Cleaning and Gryzzly-Type Sieving Machine for Rice Abstract. This research aimed to develop and a rice cleaning and grizzly-type sieving machine which also evaluates its performance. It consisted of designing, assembling, and performance evaluating of the machine. The desired machine was developed in six main components, i.e., power source, hopper, rice cleaner, rice siever, outlets, and machine frame. The research used three rotational speed treatments (Slow-Middle-Fast or L-S-C rotations) for data collections, whereas the parameters of performance testing consisted of work capacity, engine rotation speed, airflow rate, pulley rotational slip, and grain loss percentage. Engine rotation speeds at L-S-C treatments are 1654, 1817, and 1979 rpm and resulted in 7.04, 7.79, and 8.50 m/s, respectively, for airflow rates produced by the suction from a blower. The most significant rotational slip is occurred at Pulley-4 resulted in 3.27% (operating without samples) and 1.70% (operating with samples); this pulley transmitted rotational power to vibrate the 10-mesh grizzly sieve. The work capacities at L-S-C rotational treatments were 78.5, 81.6, and 146.7 kg/h, respectively. The optimal separation of brans was at C-rotational treatment, while the optimal separation of groats was at L-rotational treatment. The high percentage of grain loss occurred along with a reduction in speed that made the machine work ineffectively.


2011 ◽  
Vol 291-294 ◽  
pp. 2403-2406
Author(s):  
Yan Min Li ◽  
Fei Ma

Taking a nozzle jet for gas-fluid phase flow as a research object, the influences of the main structural parameters on the vacuum in the internal suction volume are analyzed. Utilizing the software FLUENT to simulate the gas-liquid two-phase flow in nozzle jet with different structural parameters, the pressure distributions are obtained and the relationship between the structural parameters and the vacuum in the suction volume is concerned. The results show that the vacuum in the suction volume of jet reaches the maximum when these structural parameters are some certain values. The research is helpful for the optimal design and performance testing of nozzle jets.


Author(s):  
Kristina Ludwig ◽  
Bastian Surmann ◽  
Eva Räcker ◽  
Wolfgang Greiner

Abstract Purpose The aim of this study was to develop and test a cognitive dimension as a bolt-on for the German version of the EQ-5D-Y (Youth). Methods A literature review and six focus groups with children and adolescents were used to develop the cognitive dimension for the EQ-5D-Y. In a two-phase pretest, the acceptability, feasibility and performance of this dimension were assessed (phase 1: qualitative face-to-face interviews, phase 2: standard pretest in a clinical setting). In total, 280 children and adolescents participated in this study. Results School performance, concentration, memory and learning ability represent the most important components of cognitive functioning in children and adolescents. Hence, those components were incorporated into the cognitive dimension of the EQ-5D-Y by adding four items. For children and adolescents living with a rheumatic disorder or type 1 diabetes mellitus, the EQ-5D-Y plus a cognitive bolt-on demonstrated good acceptability, feasibility and performance. The cognitive items improved the explanatory power for the EQ visual analogue scale (EQ-VAS). Factor analysis has shown that a reduction of the cognitive bolt-on into one or two item(s) is justifiable. Conclusion By enhancing the EQ-5D-Y with a cognitive bolt-on, we developed an instrument that incorporates current findings on Health-Related Quality of Life (HRQoL) and is suitable for the target population. Empirical results of this study show that cognitive functioning is an important part of HRQoL assessment in children and adolescents. The inclusion of a cognitive dimension in the EQ-5D-Y improves the HRQoL measurement.


Author(s):  
Wahyu K Sugandi ◽  
Ruminta Ruminta ◽  
Asep Yusuf ◽  
Theresia Romey

Hanjeli has a hard rind, so it takes a peeler and polisher to process it. One of the machines used is the Hanjeli Polishing Machine AGR-RM40 in the Faculty of Agriculture, Padjadjaran University. However, this machine has the disadvantage that most of the hanjeli seeds are crushed and are not polished. This is due to the polishing space which is quite narrow so that it puts great pressure on the hanjeli seeds during the polishing. Meanwhile, the existence of not polished hanjeli was caused by friction between the cylinders and hanjeli which is not maximum. Therefore, this machine needs to be modified to improve the results of a better polishing. The method used in this research was engineering with several stages, such as designing a polishing unit, analysis, and performance testing on hanjeli batu and hanjeli pulut. The modification of the Polishing Unit on Hanjeli Polishing Machine (MPBH-0219) has a cylinder length dimension of 167 mm and a diameter of 37.9 mm. Based on the performance test, this machine is good and worth using where actual capacity is obtained 35 kg / hour, 96 % engine efficiency, 58,46 % dumping yield, 0.50 performance, and 1.30 kW actual power requirements. Keywords: Hanjeli Polishing Machine, Modification, Performance Test.


2018 ◽  
Vol 18 (3) ◽  
pp. 479 ◽  
Author(s):  
Sagir Alva ◽  
Aiman Sajidah Binti Abdul Aziz ◽  
Mohd Ismahadi Bin Syono ◽  
Wan Adil Bin Wan Jamil

The Ag/AgCl reference electrode based on the Arabic Gum (AG) hydrogel films was successfully developed. The Arabic Gum concentration used in this study was 10–40% (w/v) with an optimum concentration of 20% (w/v). In this study, reference electrode performance testing is based on DmV response of Cl-ion’s measurements, stability tests and performance testing against ISE sensors such as K+, NH4+, and NO3-. The Ag/AgCl based reference electrode of the Arabic Gum film shows an average DmV of 4.0 ± 0.7 mV when response test is performed against a standard Ag/AgCl double junction electrode in various concentrations of Cl-ion’s. Meanwhile, in stability testing conducted in a 0.01 M KCl solution for 72 h found drift of < 0.6 mV/h. The reference performance test of the Arabic Gum reference electrode with three types of ISE NH4+, K+ and NO3- commercial sensors obtaining a slope closer to the Nernst value is 54.9 ± 0.9, 52.3 ± 0.5 and -53.2 ± 0.2 mV/dec with all having a linear distance of 0.1–10-5 M.


2021 ◽  
Vol 885 ◽  
pp. 33-37
Author(s):  
Veny Luvita ◽  
Setijo Bismo ◽  
Anto Tri Sugiarto

The research on phenolic compound degradation using chemical oxidation methods in a plasma reactor was performed with an Ozone-Plasma Hybrid Reactor (RHOP). This device operates by combining ozonation reactions in the liquid plasma within the reaction room. Furthermore, Ozone gas as a reagent is produced by the standard ozonator type Resun RSO-9805 made in Hong Kong and fed into this device, where the liquid phase is mixed within the injector. This way, the two-phase mixture reacts more intensively in RHOP. Also, this combination is designed to intensify hydroxyl radicals while the liquid phase is in an alkaline condition constantly exposed to plasma. The results demonstrated a continuous circulation for 2 hours at the initial concentration of 50 ppm for p-chlorophenol with a volume of 2 liters. This further obtained an 83.98% removal rate and 42.19% COD value decrease.


2021 ◽  
Vol 922 (1) ◽  
pp. 012016
Author(s):  
M Idkham ◽  
M Dhafir ◽  
Safrizal ◽  
L Putri

Abstract Palm oil fields with slopes require special wheels for transportation for transporting fresh fruit bunches (FFB), the special wheels in question are modified wheels from the existing cage wheel, the modified wheels can adjust the slope conditions on the land with the lug angle adjustment mechanism. The objective of this study was to test the functional and performance of the modified lug wheel as a means of transporting FFB on sloping land using a hand tractor on a pivot type trailer. Functional testing on the modified lug wheel was carried out by observing changes in the angle of the lugs (0, 15, 30, 45)0 by lifting one of the tractor shafts first using a jack, after which the locking pins were released. The angle change rim can be moved clockwise or anticlockwise by hand according to the desired lug angle. Performance testing on the modified lug wheel is carried out by observing and calculating the slip on the wheel. Functional testing on trailer pivots is carried out by observing all components of the towing system when installed and operated, to determine whether the trailer towing system can function properly. Performance testing on the pivot trailer is done by observing and calculating the turning radius when the tractor turns. Performance testing is also carried out by observing the stability of the two-wheel tractor and trailer. The slope of the land and the angle of the lugs greatly affect wheel slip, the higher the slope on a land, the higher the possibility of wheel slippage during operation. The test results show that the use of modified lug wheels shows better performance at 30° lug angle, as seen from the smaller slip value at 30° lug angle.


Author(s):  
A. M. Mahmoud ◽  
S. A. Sherif ◽  
W. E. Lear

Rotary-vane positive displacement machines have played an important role for many years in refrigeration and air compression applications because of their inherent simplicity and reliability. This paper details the development and testing of a rotary-vane two-phase expander for the purpose of work recovery in an air-cooled chiller. The paper describes the methodology used to design an expander for two-phase flow from a single-phase compressor and an air-motor. Input from detailed analytical models developed by the authors are used to improve the expander design with respect to internal leakage losses and friction. Controls and performance testing are also presented. Directions for future research are highlighted.


Author(s):  
Paul van de Heyning ◽  
Griet Mertens ◽  
Vedat Topsakal ◽  
Ruben de Brito ◽  
Wilhelm Wimmer ◽  
...  

Abstract Purpose Magnetic resonance imaging (MRI) is often used to visualize and diagnose soft tissues. Hearing implant (HI) recipients are likely to require at least one MRI scan during their lifetime. However, the MRI scanner can interact with the implant magnet, resulting in complications for the HI recipient. This survey, which was conducted in two phases, aimed to evaluate the safety and performance of MRI scans for individuals with a HI manufactured by MED-EL (MED-EL GmbH, Innsbruck, Austria). Methods A survey was developed and distributed in two phases to HEARRING clinics to obtain information about the use of MRI for recipients of MED-EL devices. Phase 1 focused on how often MRI is used in diagnostic imaging of the head region of the cochlear implant (CI) recipients. Phase 2 collected safety information about MRI scans performed on HI recipients. Results 106 of the 126 MRI scans reported in this survey were performed at a field strength of 1.5 T, on HI recipients who wore the SYNCHRONY CI or SYNCHRONY ABI. The head and spine were the most frequently imaged regions. 123 of the 126 scans were performed without any complications; two HI recipients experienced discomfort/pain. One recipient required reimplantation after an MRI was performed using a scanner that had not been approved for that implant. There was only one case that required surgical removal of the implant to reduce the imaging artefact. Conclusion Individuals with either a SYNCHRONY CI or SYNCHRONY ABI from MED-EL can safely undergo a 1.5 T MRI when it is performed according to the manufacturer’s safety policies and procedures.


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