scholarly journals Nanowire-Based Biosensors: From Growth to Applications

Micromachines ◽  
2018 ◽  
Vol 9 (12) ◽  
pp. 679 ◽  
Author(s):  
Pranav Ambhorkar ◽  
Zongjie Wang ◽  
Hyuongho Ko ◽  
Sangmin Lee ◽  
Kyo-in Koo ◽  
...  
Keyword(s):  
Volume Ratio ◽  
High Ionic Strength ◽  
Comprehensive Review ◽  
Biomedical Sensors ◽  
Long Term Stability ◽  
The Past ◽  
Nanowire Sensor ◽  
Working Principle ◽  
Near Future

Over the past decade, synthesized nanomaterials, such as carbon nanotube, nanoparticle, quantum dot, and nanowire, have already made breakthroughs in various fields, including biomedical sensors. Enormous surface area-to-volume ratio of the nanomaterials increases sensitivity dramatically compared with macro-sized material. Herein we present a comprehensive review about the working principle and fabrication process of nanowire sensor. Moreover, its applications for the detection of biomarker, virus, and DNA, as well as for drug discovery, are reviewed. Recent advances including self-powering, reusability, sensitivity in high ionic strength solvent, and long-term stability are surveyed and highlighted as well. Nanowire is expected to lead significant improvement of biomedical sensor in the near future.

scholarly journals Review of Ni-Cu Based Front Side Metallization for c-Si Solar Cells

2013 ◽  
Vol 2013 ◽  
pp. 1-20 ◽  
Author(s):  
Mehul C. Raval ◽  
Chetan S. Solanki
Keyword(s):  
Fill Factor ◽  
Front Side ◽  
Soldering Process ◽  
Long Term Stability ◽  
Working Principle ◽  
Reduced Costs ◽  
Near Future ◽  
Lower Series

Given the high percentage of metal cost in cell processing and concerns due to increasing Ag prices, alternative metallization schemes are being considered. Ni-Cu based front side metallization offers potential advantages of finer grid lines, lower series resistance, and reduced costs. A brief overview of various front side patterning techniques is presented. Subsequently, working principle of various plating techniques is discussed. For electroless plated Ni seed layer, fill factor values nearing 80% and efficiencies close to 17.5% have been demonstrated, while for Light Induced Plating deposited layers, an efficiency of 19.2% has been reported. Various methods for qualifying adhesion and long term stability of metal stack are discussed. Adhesion strengths in the range of 1–2.7 N/mm have been obtained for Ni-Cu contacts tabbed with conventional soldering process. Given the significance of metallization properties, different methods for characterization are outlined. The problem of background plating for Ni-Cu based metallization along with the various methods for characterization is summarized. An economic evaluation of front side metallization indicates process cost saving of more than 50% with Ni-Cu-Sn based layers. Recent successful commercialization and demonstration of Ni-Cu based metallization on industrial scale indicate a potential major role of Ni-Cu based contacts in near future.

scholarly journals Acute graft-versus-host disease: a bench-to-bedside update

Blood ◽  
2014 ◽  
Vol 124 (3) ◽  
pp. 363-373 ◽  
Author(s):  
Shernan G. Holtan ◽  
Marcelo Pasquini ◽  
Daniel J. Weisdorf
Keyword(s):  
Small Molecules ◽  
Graft Versus Host Disease ◽  
Host Disease ◽  
Multiple Modalities ◽  
Graft Versus Host ◽  
The Past ◽  
Prevention And Treatment ◽  
Near Future ◽  
Acute Graft

Abstract Over the past 5 years, many novel approaches to early diagnosis, prevention, and treatment of acute graft-versus-host disease (aGVHD) have been translated from the bench to the bedside. In this review, we highlight recent discoveries in the context of current aGVHD care. The most significant innovations that have already reached the clinic are prophylaxis strategies based upon a refinement of our understanding of key sensors, effectors, suppressors of the immune alloreactive response, and the resultant tissue damage from the aGVHD inflammatory cascade. In the near future, aGVHD prevention and treatment will likely involve multiple modalities, including small molecules regulating immunologic checkpoints, enhancement of suppressor cytokines and cellular subsets, modulation of the microbiota, graft manipulation, and other donor-based prophylaxis strategies. Despite long-term efforts, major challenges in treatment of established aGVHD still remain. Resolution of inflammation and facilitation of rapid immune reconstitution in those with only a limited response to corticosteroids is a research arena that remains rife with opportunity and urgent clinical need.

Risking Debt for Honor

2017 ◽  
Vol 43 (1) ◽  
pp. 51-71
Author(s):  
Jennifer R. Cash
Keyword(s):  
Social Relations ◽  
Social Life ◽  
Urban Migration ◽  
Long Term Stability ◽  
The Past ◽  
Political Upheaval ◽  
The Social ◽  
Rural Urban Migration ◽  
The Republic

Research on godparenthood has traditionally emphasized its stabilizing effect on social structure. This article, however, focuses attention on how the practices and discourses associated with marital sponsorship in the Republic of Moldova ascribe value to the risks and uncertainties of social life. Moldova has experienced substantial economic, social, and political upheaval during the past two decades of postsocialism, following a longer period of Soviet-era modernization, secularization, and rural–urban migration. In this context, godparenthood has not contributed to the long-term stability of class structure or social relations, but people continue to seek honor and social respect by taking the social and economic risks involved in sponsoring new marriages.

A Review of Preparation and Tribological Applications of Pickering Emulsion

2021 ◽  
pp. 1-27
Author(s):  
Yichen Bao ◽  
Kai Liu ◽  
Quan Zheng ◽  
Lulu Yao ◽  
Yufu Xu
Keyword(s):  
Pickering Emulsion ◽  
Solid Particles ◽  
Preparation Methods ◽  
Factors Affecting ◽  
Long Term Stability ◽  
New Strategy ◽  
New Type ◽  
The Stability ◽  
Near Future

Abstract Pickering emulsion is a new type of stable emulsion made by ultra-fine solid particles instead of traditional surfactants as stabilizers, which has received widespread attention in recent years. The preparation methods of stator-rotor homogenization, high-pressure homogenization, and ultrasonic emulsification were compared with others in this work. The main factors affecting the stability of Pickering emulsion are the surface humidity of the solid particles, the polarity of the oil phase, and the oil-water ratio. These factors could affect the nature of the solid particles, the preparation process of Pickering emulsion and the external environment. Consequently, the long-term stability of Pickering emulsion is still a challenge. The tribological investigations of Pickering emulsion were summarized, and the multifunctional Pickering emulsion shows superior prospects for tribological applications. Moreover, the latest development of Pickering emulsion offers a new strategy for smart lubrication in the near future.

The End of Family Business? The Mittelstand and German Capitalism in Transition, 1949–2000

2006 ◽  
Vol 80 (2) ◽  
pp. 263-295 ◽  
Author(s):  
Hartmut Berghoff
Keyword(s):  
Family Business ◽  
Family Firms ◽  
German Economy ◽  
Term Stability ◽  
Long Term Stability ◽  
Sociocultural Environment ◽  
The Past ◽  
The 1960S ◽  
Modern Form

TheMittelstandsector of the German economy, which is made up of small and medium-sized family firms, is generally not mentioned in debates about German capitalism. This article makes the case that the focus of research on the German economy should shift from large corporate structures to these smaller firms. The classic Mittelstand model, which dominated the economy until about 1970, was characterized by identity of ownership and management, strong emotional investment by owners and staff, and an emphasis on continuity, paternalism, and independence. Beginning in the 1960s, this model was undermined by fundamental changes in the country's economic and sociocultural environment. In response, the firms abandoned a number of their traditional attributes, a process that led to the demise of some businesses and the regeneration of others. Although the modern form adopted by the surviving Mittelstand firms allows them to be less dependent on individual families, to enjoy more access to external capital, and to display more openness and international orientation, they can no longer rely on the prospect of long-term stability, as they did in the past.

The End of Family Business? The Mittelstand and German Capitalism in Transition, 1949–2000

2006 ◽  
Vol 80 (2) ◽  
pp. 263-295 ◽  
Author(s):  
Hartmut Berghoff
Keyword(s):  
Family Business ◽  
Family Firms ◽  
German Economy ◽  
Term Stability ◽  
Long Term Stability ◽  
Sociocultural Environment ◽  
The Past ◽  
The 1960S ◽  
Modern Form

TheMittelstandsector of the German economy, which is made up of small and medium-sized family firms, is generally not mentioned in debates about German capitalism. This article makes the case that the focus of research on the German economy should shift from large corporate structures to these smaller firms. The classic Mittelstand model, which dominated the economy until about 1970, was characterized by identity of ownership and management, strong emotional investment by owners and staff, and an emphasis on continuity, paternalism, and independence. Beginning in the 1960s, this model was undermined by fundamental changes in the country's economic and sociocultural environment. In response, the firms abandoned a number of their traditional attributes, a process that led to the demise of some businesses and the regeneration of others. Although the modern form adopted by the surviving Mittelstand firms allows them to be less dependent on individual families, to enjoy more access to external capital, and to display more openness and international orientation, they can no longer rely on the prospect of long-term stability, as they did in the past.

Aeronautics-1903; aerospace-2003; ? ? 2103

2005 ◽  
Vol 219 (3) ◽  
pp. 235-260
Author(s):  
J E Allen
Keyword(s):  
21St Century ◽  
The Past ◽  
Energy Substitution ◽  
The Future ◽  
Manned Flight ◽  
Aeronautical Engineering ◽  
Wilbur Wright ◽  
Near Future ◽  
Rare Opportunity

The centenary of the first manned flight was a unique occasion permitting a rare opportunity to range far into both the past and the future. Most of aeronautics must inevitably be focussed on the near future and immediate actions. However, there are some very long-term underlying issues which are invisible from a day-to-day perspective, but which should not be overlooked as they can be used very often to guide decisions that might otherwise be unsound. In Part 1, the paper reviews the major breakthroughs that have impelled aeronautics along a startling trajectory of success, with some mention of the uncertain beginnings, when even Wilbur Wright considered that all his aerodynamic theories were in a muddle. In that spirit, in Part 2, some attempts are made to anticipate possible breakthroughs that might happen in the 21st century. However, aeronautics does not stand alone. Considerations, such as other transport modes, energy substitution, non-vehicular transport, and the consequences of major global political alignments, will be reviewed in order to seek new aeronautical challenges of the future. Some other long-term, but non-aeronautical engineering, initiatives relevant to the IMechE are introduced and discussed in the appendix

scholarly journals Sensing Properties of Oxidized Nanostructured Silicon Surface on Vaporized Molecules

Sensors ◽  
2019 ◽  
Vol 19 (1) ◽  
pp. 119 ◽  
Author(s):  
Nikola Baran ◽  
Hrvoje Gebavi ◽  
Lara Mikac ◽  
Davor Ristić ◽  
Marijan Gotić ◽  
...  
Keyword(s):  
Porous Silicon ◽  
Electrochemical Etching ◽  
Ammonia Gas ◽  
Sensing Properties ◽  
Long Term Stability ◽  
The Past ◽  
Oxygen Treatment ◽  
Ambient Concentration ◽  
Potential Use

Porous silicon has been intensely studied for the past several decades and its applications were found in photovoltaics, biomedicine, and sensors. An important aspect for sensing devices is their long–term stability. One of the more prominent changes that occur with porous silicon as it is exposed to atmosphere is oxidation. In this work we study the influence of oxidation on the sensing properties of porous silicon. Porous silicon layers were prepared by electrochemical etching and oxidized in a tube furnace. We observed that electrical resistance of oxidized samples rises in response to the increasing ambient concentration of organic vapours and ammonia gas. Furthermore, we note the sensitivity is dependent on the oxygen treatment of the porous layer. This indicates that porous silicon has a potential use in sensing of organic vapours and ammonia gas when covered with an oxide layer.

scholarly journals Infrastructure autopoiesis: requisite variety to engage complexity

2022 ◽  
Author(s):  
Mikhail V Chester ◽  
Braden Allenby
Keyword(s):  
Infrastructure Systems ◽  
Long Term Stability ◽  
The Core ◽  
The Past ◽  
Knowledge Processes ◽  
Requisite Variety ◽  
Horizon Scanning ◽  
The Face ◽  
Conditions Of Stability

Abstract Infrastructure systems must change to match the growing complexity of the environments they operate in. Yet the models of governance and the core technologies they rely on are structured around models of relative long-term stability that appear increasingly insufficient and even problematic. As the environments in which infrastructure function become more complex, infrastructure systems must adapt to develop a repertoire of responses sufficient to respond to the increasing variety of conditions and challenges. Whereas in the past infrastructure leadership and system design has emphasized organization strategies that primarily focus on exploitation (e.g., efficiency and production, amenable to conditions of stability), in the future they must create space for exploration, the innovation of what the organization is and does. They will need to create the abilities to maintain themselves in the face of growing complexity by creating the knowledge, processes, and technologies necessary to engage environment complexity. We refer to this capacity as infrastructure autopoiesis. In doing so infrastructure organizations should focus on four key tenets. First, a shift to sustained adaptation – perpetual change in the face of destabilizing conditions often marked by uncertainty – and away from rigid processes and technologies is necessary. Second, infrastructure organizations should pursue restructuring their bureaucracies to distribute more resources and decisionmaking capacity horizontally, across the organization’s hierarchy. Third, they should build capacity for horizon scanning, the process of systematically searching the environment for opportunities and threats. Fourth, they should emphasize loose fit design, the flexibility of assets to pivot function as the environment changes. The inability to engage with complexity can be expected to result in a decoupling between what our infrastructure systems can do and what we need them to do, and autopoietic capabilities may help close this gap by creating the conditions for a sufficient repertoire to emerge.

scholarly journals A gazdasági és társadalmi fejlődés elősegíti-e az emberek elégedettségének és boldogságának növekedését Kínában?

2018 ◽  
Vol 9 (2017/1) ◽  
Author(s):  
Anett Kozjek-Gulyás
Keyword(s):  
Decision Makers ◽  
Chinese Government ◽  
Healthy Development ◽  
Long Term Stability ◽  
The Past ◽  
Political Perspective ◽  
Level Of Satisfaction ◽  
Starting Point ◽  
Made In

Whether a society is satisfied or not always provides important informationon the operation of a country, from an economic and political perspective,among others. To what extent can we speak of healthy development of thesociety? How many in this society are dissatisfied with their situation and seethe future prospects for themselves and their families hopeless? The answersto these questions can provide valuable feedback for the decision makers onthe consequences of the decisions they made in the past and are making atpresent. This study utilizes the findings of empirical research carried out inJanuary 2015 in Qinhuangdao 秦皇岛 as a starting point and aims to draw conclusions from the indicators of the level of satisfaction with the performance of the Chinese government – from the analysis of the indicators of happiness and satisfaction – to determine how much the subjective well-beingof everyday Chinese people contribute to the long-term stability of the system of government and the undisturbed operation of China’s political system.

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