scholarly journals Optic Nerve Stimulation System with Adaptive Wireless Powering and Data Telemetry

Micromachines ◽  
2017 ◽  
Vol 8 (12) ◽  
pp. 368 ◽  
Author(s):  
Xing Li ◽  
Yan Lu ◽  
Xiaodong Meng ◽  
Chi-Ying Tsui ◽  
Wing-Hung Ki
Keyword(s):  
Optic Nerve ◽  
Nerve Stimulation ◽  
Wireless Powering ◽  
Optic Nerve Stimulation ◽  
Stimulation System

Mu¨ller cell depolarization evoked by antidromic optic nerve stimulation

1977 ◽  
Vol 121 (1) ◽  
pp. 162-166 ◽  
Author(s):  
Robert F. Miller ◽  
Ramon Dacheux ◽  
Luis Proenza
Keyword(s):  
Optic Nerve ◽  
Nerve Stimulation ◽  
Optic Nerve Stimulation ◽  
Cell Depolarization

scholarly journals A machine-learning algorithm correctly classifies cortical evoked potentials from both natural retinal stimulation and electrical stimulation of the optic nerve

2021 ◽  
Author(s):  
Vivien Gaillet ◽  
Elodie Geneviève Zollinger ◽  
Diego Ghezzi
Keyword(s):  
Electrical Stimulation ◽  
Visual Cortex ◽  
Optic Nerve ◽  
Visual Field ◽  
Primary Visual Cortex ◽  
Nerve Stimulation ◽  
Visual Stimulation ◽  
Cortical Activity ◽  
Artificial Vision ◽  
Optic Nerve Stimulation

AbstractObjectiveOptic nerve’s intraneural stimulation is an emerging neuroprosthetic approach to provide artificial vision to totally blind patients. An open question is the possibility to evoke individual non-overlapping phosphenes via selective intraneural optic nerve stimulation. To begin answering this question, first, we aim at showing in preclinical experiments with animals that each intraneural electrode could evoke a distinguishable activity pattern in the primary visual cortex.ApproachWe performed both patterned visual stimulation and patterned electrical stimulation in healthy rabbits while recording evoked cortical activity with an electrocorticogram array in the primary visual cortex. Electrical stimulation was delivered to the optic nerve with the intraneural array OpticSELINE. We used a support vector machine algorithm paired to a linear regression model to classify cortical responses originating from visual stimuli located in different portions of the visual field and electrical stimuli from the different electrodes of the OpticSELINE.Main resultsCortical activity induced by visual and electrical stimulation could be classified with nearly 100% accuracy relative to the specific location in the visual field or electrode in the array from which it originated. For visual stimulation, the accuracy increased with the separation of the stimuli and reached 100% for separation higher than 7 degrees. For electrical stimulation, at low current amplitudes, the accuracy increased with the distance between electrodes, while at higher current amplitudes, the accuracy was nearly 100% already for the shortest separation.SignificanceOptic nerve’s intraneural stimulation with the OpticSELINE induced discernible cortical activity patterns. These results represent a leap forward for intraneural optic nerve stimulation towards artificial vision.

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