scholarly journals Recent Insights and Multifactorial Applications of Carbon Nanotubes

Micromachines ◽  
2021 ◽  
Vol 12 (12) ◽  
pp. 1502
Author(s):  
Muthu Thiruvengadam ◽  
Govindasamy Rajakumar ◽  
Venkata Swetha ◽  
Mohammad Azam Ansari ◽  
Saad Alghamdi ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Near Infrared ◽  
Medical Diagnostics ◽  
Cortical Atrophy ◽  
Silicon Chips ◽  
Therapeutic Modalities ◽  
Wide Range ◽  
High Flexibility ◽  
Carbon Based Nanomaterials

Nanotechnology has undergone significant development in recent years, particularly in the fabrication of sensors with a wide range of applications. The backbone of nanotechnology is nanostructures, which are determined on a nanoscale. Nanoparticles are abundant throughout the universe and are thought to be essential building components in the process of planet creation. Nanotechnology is generally concerned with structures that are between 1 and 100 nm in at least one dimension and involves the production of materials or electronics that are that small. Carbon nanotubes (CNTs) are carbon-based nanomaterials that have the structure of tubes. Carbon nanotubes are often referred to as the kings of nanomaterials. The diameter of carbon is determined in nanometers. They are formed from graphite sheets and are available in a variety of colors. Carbon nanotubes have a number of characteristics, including high flexibility, good thermal conductivity, low density, and chemical stability. Carbon nanotubes have played an important part in nanotechnology, semiconductors, optical and other branches of materials engineering owing to their remarkable features. Several of the applications addressed in this review have already been developed and used to benefit people worldwide. CNTs have been discussed in several domains, including industry, construction, adsorption, sensors, silicon chips, water purifiers, and biomedical uses, to show many treatments such as injecting CNTs into kidney cancers in rats, drug delivery, and directing a near-infrared laser at the cancers. With the orderly development of research in this field, additional therapeutic modalities will be identified, mainly for dispersion and densification techniques and targeted drug delivery systems for managing and curing posterior cortical atrophy. This review discusses the characteristics of carbon nanotubes as well as therapeutic applications such as medical diagnostics and drug delivery.

Biomedical Applications of Nanoparticles

2022 ◽  
pp. 289-311
Author(s):  
Raghavv Raghavender Suresh ◽  
Shruthee Sankarlinkam ◽  
Sai Rakshana Karuppusami ◽  
Niraimathi Pandiyan ◽  
Suwetha Bharathirengan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Medical Diagnostics ◽  
Engineered Nanoparticles ◽  
Biological Molecules ◽  
Toxicological Evaluation ◽  
Nanodrug Delivery ◽  
Novel Drugs ◽  
Wide Range ◽  
Targeted Drug

In recent years, there has been significant growth and burgeoning interest in utilizing nanoparticles for various biomedical applications, including medical diagnostics, targeted drug delivery, tissue engineering, regenerative medicine, and biomedical textiles. In particular, nanoparticles functionalized with biological molecules have unique properties and are very effective in medical diagnostics. Besides that, nanoparticles have a wide range of therapeutic applications, including the development of nanodrug delivery systems, the design of novel drugs, as well as their contribution to the design of therapeutic materials. This chapter provides an overview of recent advancements in the biomedical applications of nanoparticles. Finally, this chapter discusses the challenges of the toxicological evaluation of engineered nanoparticles and the importance of conducting detailed studies on the synthesis of future nanomaterials to develop cutting-edge technologies for addressing a wide range of biomedical issues.

Fabrication of Precise Asymmetric Nanoshells Array with Nanogaps for a Label-Free Immunoassay Based on NIR-Light Responsive LSPR

2012 ◽  
Vol 523-524 ◽  
pp. 680-685
Author(s):  
Shuhei Uchida ◽  
Kazuya Yamamura ◽  
Nobuyuki Zettsu
Keyword(s):  
Near Infrared ◽  
Atmospheric Pressure Plasma ◽  
High Sensitivity ◽  
Medical Diagnostics ◽  
Localized Surface Plasmon ◽  
Label Free ◽  
Fabrication Technique ◽  
Alternative Structures ◽  
Wide Range ◽  
Surrounding Refractive Index

Localized surface plasmon resonance (LSPR) based sensors are a well established technology utilized for label-free biochemical sensing in immunoassay, medical diagnostics and environmental monitoring. The understanding of asymmetric metal nanoparticles, new object for complex, coupled plasmon systems providing localized significantly enhanced E-field, is central to a wide range of novel applications and processes in science of higher sensitive sensing systems. However, few methods are available for actual characterization of such nanostructures at the single particle level. Here we propose a precise and large sized scale fabrication technique for asymmetric nanoshells array with nanogaps of several tens of nanometers for LSPR sensor through atmospheric pressure plasma etching processes. A nanoshell was simply constructed by laminating thin Au films on periodic isolated polymer nanoparticles template. This nanoshells array was expected to exhibit specific near-infrared plasmonic properties. When measuring the sensitivity, nanoshells array exhibited a high sensitivity to changes of surrounding refractive index and showed a higher sensor figure of merit than the alternative structures. This indicated that the enhanced plasmon E-field in the asymmetric nanostructures improved sensor performance. Our fabrication technique and the optical properties of the arrays will provide useful information for developing new plasmonic applications.

Pharmaceutical Applications of Carbon Nanotube-Mediated Drug Delivery Systems

2012 ◽  
Vol 5 (2) ◽  
pp. 1685-1696 ◽  
Author(s):  
Pradeep Kumar S ◽  
Prathibha D ◽  
Gowri Shankar N L ◽  
Parthibarajan R ◽  
Mastyagiri L ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Cancer Treatment ◽  
Drug Delivery System ◽  
Delivery System ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Width Ratio ◽  
Wide Range

Carbon nanotubes, which are elongated fullerenes, resemble graphite sheets wrapped into cylinders with a high length-to-width ratio (few nm in diameter and up to 1 mm in length). Carbon nanotubes are molecular-scale tubes of graphitic carbon with outstanding properties. Carbon nanotubes have drawn great interest and attraction in the field of novel drug delivery system. Nanomedicines can target, diagnose, monitor and treat cancerous cell also. The small nanoscale dimension and astonishing properties make them a distinctive carrier with a wide range of promising applications. These cylindrical carbon molecules have novel properties that make them potentially useful in many applications in nanotechnology. The various nano-size carrier systems are available for biotechnological applications including the drug delivery. Carbon nanotubes are typically used for bioactive delivery due to their some unique outstanding properties. Carbon nanotubes drug delivery system opens up new potential and possibilities over nanoparticles, dendrimers, liposomes etc. for biomedical applications and new drug delivery. In last few years, Carbon nanotubes (CNTs) have shown unexpected advantages in the field of cancer treatment and drug delivery systems. Present review article discuss in brief about the methods of synthesis, with purification as well as sorting techniques for giving different grades to different types of CNTs and biomedical applications. These show very good adsorption properties which helps in the detection of various chemicals, toxic agents etc. Research done using CNTs for cancer treatment is also discussed in brief.  

scholarly journals Design and Application of Near-Infrared Nanomaterial-Liposome Hybrid Nanocarriers for Cancer Photothermal Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2070
Author(s):  
Pan Liang ◽  
Linshen Mao ◽  
Yanli Dong ◽  
Zhenwen Zhao ◽  
Qin Sun ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Release Mechanism ◽  
Enhanced Photoluminescence ◽  
Drug Release Mechanism ◽  
Stimulus Responsive ◽  
Stable Particles ◽  
Carbon Based Nanomaterials

Liposomes are attractive carriers for targeted and controlled drug delivery receiving increasing attention in cancer photothermal therapy. However, the field of creating near-infrared nanomaterial-liposome hybrid nanocarriers (NIRN-Lips) is relatively little understood. The hybrid nanocarriers combine the dual superiority of nanomaterials and liposomes, with more stable particles, enhanced photoluminescence, higher tumor permeability, better tumor-targeted drug delivery, stimulus-responsive drug release, and thus exhibiting better anti-tumor efficacy. Herein, this review covers the liposomes supported various types of near-infrared nanomaterials, including gold-based nanomaterials, carbon-based nanomaterials, and semiconductor quantum dots. Specifically, the NIRN-Lips are described in terms of their feature, synthesis, and drug-release mechanism. The design considerations of NIRN-Lips are highlighted. Further, we briefly introduced the photothermal conversion mechanism of NIRNs and the cell death mechanism induced by photothermal therapy. Subsequently, we provided a brief conclusion of NIRNs-Lips applied in cancer photothermal therapy. Finally, we discussed a synopsis of associated challenges and future perspectives for the applications of NIRN-Lips in cancer photothermal therapy.

scholarly journals Carbon Nanotubes in Cancer Therapy and Drug Delivery

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Abdelbary M. A. Elhissi ◽  
Waqar Ahmed ◽  
Israr Ul Hassan ◽  
Vinod. R. Dhanak ◽  
Antony D'Emanuele
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Surface Area ◽  
Biological Properties ◽  
Major Focus ◽  
Carrier System ◽  
Wide Range ◽  
Therapeutic Molecules

Carbon nanotubes (CNTs) have been introduced recently as a novel carrier system for both small and large therapeutic molecules. CNTs can be functionalized (i.e., surface engineered) with certain functional groups in order to manipulate their physical or biological properties. In addition to the ability of CNTs to act as carriers for a wide range of therapeutic molecules, their large surface area and possibility to manipulate their surfaces and physical dimensions have been exploited for use in the photothermal destruction of cancer cells. This paper paper will discuss the therapeutic applications of CNTs with a major focus on their applications for the treatment of cancer.

scholarly journals Differential GFR estimation of the double moiety kidneys by modified GATE’S formula

2021 ◽  
Vol 3 (3) ◽  
pp. 01-07
Author(s):  
Sivasubramaniyan V
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Physical Properties ◽  
Tissue Regeneration ◽  
Biomedical Applications ◽  
Living Cells ◽  
Advanced Imaging ◽  
Wide Range ◽  
Gfr Estimation ◽  
Or Gene

Since the beginning of the twenty-one century, carbon based nanomaterial (CNTs) has been introduced in (pharmacy and medicine) in therapeutic for system of drug delivery. NTs have proved able to transport a wide range of molecules across membranes and into living cells; therefore, they have attracted great interest in biomedical applications such as advanced imaging, tissue regeneration, and drug or gene deliver. As it is known, carbon nanotubes exhibit various unique intrinsic chemical and physical properties and it has been intensive explored, in the last few years, for applications in biology and biomedicine.

scholarly journals A review on the synthesis, surface modification and drug delivery of nanoparticles

2021 ◽  
Vol 8 (2) ◽  
pp. 032-045
Author(s):  
Md Dipu Ahmed ◽  
Kazi M Maraz ◽  
Shahirin Shahida ◽  
Tarannum Dihan ◽  
Ruhul A Khan
Keyword(s):  
Drug Delivery ◽  
Near Infrared ◽  
Materials Science ◽  
Health Sector ◽  
Review Article ◽  
Infrared Light ◽  
The Past ◽  
Inorganic Substances ◽  
Wide Range ◽  
Potential Impact

Over the past few years, the evolution of nanotechnology has extended into a wide range of applications. Nanotechnology has now become a multidisciplinary science that applies to electronics, materials science, biomedical engineering, microbiology, etc. Recently, nanotechnology is being used in biomedical and pharmaceutical science. Among them drug delivery is set to spread rapidly. Application of nanotechnology in health sector also created a potential impact such as in the fields of immunology, cardiology, endocrinology, ophthalmology, and oncology. Nanoparticles are unique because of their large surface area and it has the potential to change the properties of a bulk number of materials. The surface of nanoparticles can be modified with the help of various polymers, organic and inorganic substances according to the specific application and their use. Nanoparticles are also utilized as nano shells in drug delivery systems and cancer therapy. Nano shells can recognize the cancer cells when they are injected into the cancer area. The heat generated by the light absorbing nano shells due to the application of the near infrared light successfully kills tumour cells leaving the noncarcinogenic cells intact. In this review article, nanoparticles, the health implication of nanoparticles and their synthesis are discussed.

scholarly journals Long-Term In Vivo Biocompatibility of Single-Walled Carbon Nanotubes

2019 ◽  
Author(s):  
Thomas V. Galassi ◽  
Merav Antman-Passig ◽  
Zvi Yaari ◽  
Jose Jessurun ◽  
Robert E. Schwartz ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Carbon Nanotube ◽  
Near Infrared ◽  
Complete Blood Count ◽  
Aggregation State ◽  
Single Walled Carbon ◽  
Wide Range ◽  
Short And Long Term

AbstractOver the past two decades, measurements of carbon nanotube toxicity and biodistribution have yielded a wide range of results. Properties such as nanotube type (single-walled vs. multi-walled), purity, length, aggregation state, and functionalization, as well as route of administration, greatly affect both the biocompatibility and biodistribution of carbon nanotubes. These differences suggest that generalizable conclusions may be elusive and that studies must be material- and application-specific. Here, we assess the short- and long-term biodistribution and biocompatibility of a single-chirality DNA-encapsulated single-walled carbon nanotube complex upon intravenous administration that was previously shown to function as an in-vivo reporter of endolysosomal lipid accumulation. Regarding biodistribution and fate, we found bulk specificity to the liver and >90% signal attenuation by 14 days in mice. Using near-infrared hyperspectral microscopy to measure single nanotubes, we found low-level, long-term persistence in organs such as the heart, liver, lung, kidney, and spleen. Measurements of histology, animal weight, complete blood count, and biomarkers of organ function all suggest short- and long-term biocompatibility. This work suggests that carbon nanotubes can be used as preclinical research tools in-vivo without affecting acute or long-term health.

scholarly journals Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Xuexiang Han ◽  
Yiye Li ◽  
Ying Xu ◽  
Xiao Zhao ◽  
Yinlong Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Stromal Cells ◽  
Stellate Cells ◽  
Tumour Microenvironment ◽  
Pancreatic Stellate Cells ◽  
Ductal Adenocarcinoma ◽  
Combination Strategy ◽  
Therapeutic Modalities ◽  
Wide Range ◽  
Desmoplastic Stroma

AbstractPancreatic ductal adenocarcinoma is characterised by a dense desmoplastic stroma composed of stromal cells and extracellular matrix (ECM). This barrier severely impairs drug delivery and penetration. Activated pancreatic stellate cells (PSCs) play a key role in establishing this unique pathological obstacle, but also offer a potential target for anti-tumour therapy. Here, we construct a tumour microenvironment-responsive nanosystem, based on PEGylated polyethylenimine-coated gold nanoparticles, and utilise it to co-deliver all-trans retinoic acid (ATRA, an inducer of PSC quiescence) and siRNA targeting heat shock protein 47 (HSP47, a collagen-specific molecular chaperone) to re-educate PSCs. The nanosystem simultaneously induces PSC quiescence and inhibits ECM hyperplasia, thereby promoting drug delivery to pancreatic tumours and significantly enhancing the anti-tumour efficacy of chemotherapeutics. Our combination strategy to restore homoeostatic stromal function by targeting activated PSCs represents a promising approach to improving the efficacy of chemotherapy and other therapeutic modalities in a wide range of stroma-rich tumours.

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