scholarly journals Computational Simulations in Advanced Microfluidic Devices: A Review

Micromachines ◽  
2021 ◽  
Vol 12 (10) ◽  
pp. 1149
Author(s):  
Violeta Carvalho ◽  
Raquel O. Rodrigues ◽  
Rui A. Lima ◽  
Senhorinha Teixeira
Keyword(s):  
Diffusion Processes ◽  
Microfluidic Devices ◽  
Shear Stresses ◽  
Biological Processes ◽  
Physical Processes ◽  
Computational Tools ◽  
Numerical Studies ◽  
Supporting Tool ◽  
Insight Into ◽  
Made In

Numerical simulations have revolutionized research in several engineering areas by contributing to the understanding and improvement of several processes, being biomedical engineering one of them. Due to their potential, computational tools have gained visibility and have been increasingly used by several research groups as a supporting tool for the development of preclinical platforms as they allow studying, in a more detailed and faster way, phenomena that are difficult to study experimentally due to the complexity of biological processes present in these models—namely, heat transfer, shear stresses, diffusion processes, velocity fields, etc. There are several contributions already in the literature, and significant advances have been made in this field of research. This review provides the most recent progress in numerical studies on advanced microfluidic devices, such as organ-on-a-chip (OoC) devices, and how these studies can be helpful in enhancing our insight into the physical processes involved and in developing more effective OoC platforms. In general, it has been noticed that in some cases, the numerical studies performed have limitations that need to be improved, and in the majority of the studies, it is extremely difficult to replicate the data due to the lack of detail around the simulations carried out.

Will Love Tear Us Apart: Adapting the Lyrical to the Ludic

CounterText ◽  
2016 ◽  
Vol 2 (2) ◽  
pp. 217-235
Author(s):  
Gordon Calleja
Keyword(s):  
Design Process ◽  
Game Design ◽  
Digital Games ◽  
Design Decisions ◽  
The Core ◽  
Lyrical Poetry ◽  
Insight Into ◽  
Made In

This paper gives an insight into the design process of a game adaptation of Joy Division's Love Will Tear Us Apart (1980). It outlines the challenges faced in attempting to reconcile the diverging qualities of lyrical poetry and digital games. In so doing, the paper examines the design decisions made in every segment of the game with a particular focus on the tension between the core concerns of the lyrical work being adapted and established tenets of game design.

An Insight into Oligopeptide Transporter 3 (OPT3) family proteins

2020 ◽  
Vol 27 ◽  
Author(s):  
Fırat Kurt
Keyword(s):  
Stress Responses ◽  
Chelating Agent ◽  
Biological Processes ◽  
Biotic And Abiotic Stress ◽  
Oligopeptide Transporter ◽  
Binding Residues ◽  
Fe Homeostasis ◽  
Proteins Interactions ◽  
Insight Into ◽  
Selection Of

: Oligopeptide transporter 3 (OPT3) proteins are one of the subsets of OPT clade, yet little is known about these transporters. Therefore, homolog OPT3 proteins in several plant species were investigated and characterized using bioinformatical tools. Motif and co-expression analyses showed that OPT3 proteins may be involved in both biotic and abiotic stress responses as well as growth and developmental processes. AtOPT3 usually seemed to take part in Fe homeostasis whereas ZmOPT3 putatively interacted with proteins involved in various biological processes from plant defense system to stress responses. Glutathione (GSH), as a putative alternative chelating agent, was used in the AtOPT3 and ZmOPT3 docking analyses to identify their putative binding residues. The information given in this study will contribute to the understanding of OPT3 proteins’ interactions in various pathways and to the selection of potential ligands for OPT3s.

Insight into the formation of H-bonds propagating the monomeric zinc complexes of a tridentate reduced Schiff base to form an infinite chain

CrystEngComm ◽  
2021 ◽  
Author(s):  
Mainak Karmakar ◽  
Antonio Frontera ◽  
Shouvik Chattopadhyay
Keyword(s):  
Schiff Base ◽  
Solid State ◽  
Dft Calculations ◽  
Zinc Complexes ◽  
Infinite Chain ◽  
State Structure ◽  
Computational Tools ◽  
Solid State Structure ◽  
Reduced Schiff Base ◽  
Insight Into

The formation of an infinite 1D assembly is governed by the H-bonding interactions in the solid state structure of the two zinc complexes. It has been analyzed energetically using DFT calculations and several computational tools.

scholarly journals A NuSTAR confirmation of the 36 ks hard X-ray pulse-phase modulation in the magnetar 1E 1547.0 − 5408

2021 ◽  
Vol 502 (2) ◽  
pp. 2266-2284
Author(s):  
Kazuo Makishima ◽  
Teruaki Enoto ◽  
Hiroki Yoneda ◽  
Hirokazu Odaka
Keyword(s):  
Time Lapse ◽  
Phase Behaviour ◽  
Modulation Amplitude ◽  
Axial Deformation ◽  
Physical Processes ◽  
Arrival Times ◽  
Pulse Phase ◽  
Phase Variations ◽  
Complex Phenomena ◽  
Made In

ABSTRACT This paper describes an analysis of the NuSTAR data of the fastest-rotating magnetar 1E 1547 − 5408, acquired in 2016 April for a time lapse of 151 ks. The source was detected with a 1–60 keV flux of 1.7 × 10−11 erg s−1 cm−2, and its pulsation at a period of 2.086710(5) s. In 8–25 keV, the pulses were phase-modulated with a period of T = 36.0 ± 2.3 ks, and an amplitude of ∼0.2 s. This reconfirms the Suzaku discovery of the same effect at $T=36.0 ^{+4.5}_{-2.5}$ ks, made in the 2009 outburst. These results strengthen the view derived from the Suzaku data, that this magnetar performs free precession as a result of its axial deformation by ∼0.6 × 10−4, possibly caused by internal toroidal magneti fields (MFs) reaching ∼1016 G. Like in the Suzaku case, the modulation was not detected in energies below ∼8 keV. Above 10 keV, the pulse-phase behaviour, including the 36 ks modulation parameters, exhibited complex energy dependencies: at ∼22 keV, the modulation amplitude increased to ∼0.5 s, and the modulation phase changed by ∼65° over 10–27 keV, followed by a phase reversal. Although the pulse significance and pulsed fraction were originally very low in >10 keV, they both increased noticeably, when the arrival times of individual photons were corrected for these systematic pulse-phase variations. Possible origins of these complex phenomena are discussed, in terms of several physical processes that are specific to ultrastrong MFs.

New insight into the molecular switch mechanism of human Rho family proteins: shifting a paradigm

2013 ◽  
Vol 394 (1) ◽  
pp. 89-95 ◽  
Author(s):  
Mamta Jaiswal ◽  
Eyad Kalawy Fansa ◽  
Radovan Dvorsky ◽  
Mohammad Reza Ahmadian
Keyword(s):  
Quantitative Analysis ◽  
Bound State ◽  
Molecular Switch ◽  
Nucleotide Exchange ◽  
Gtp Binding ◽  
Switch Mechanism ◽  
Rho Family ◽  
Rho Family Proteins ◽  
Insight Into ◽  
Made In

Abstract Major advances have been made in understanding the structure, function and regulation of the small GTP-binding proteins of the Rho family and their involvement in multiple cellular process and disorders. However, intrinsic nucleotide exchange and hydrolysis reactions, which are known to be fundamental to Rho family proteins, have been partially investigated in the case of RhoA, Rac1 and Cdc42, but for others not at all. Here we present a comprehensive and quantitative analysis of the molecular switch functions of 15 members of the Rho family that enabled us to propose an active GTP-bound state for the rather uncharacterized isoforms RhoD and Rif under equilibrium and quiescent conditions.

Formation, translocation and resolution of Holliday junctions during homologous genetic recombination

1995 ◽  
Vol 347 (1319) ◽  
pp. 21-25 ◽  
Keyword(s):  
Molecular Mechanisms ◽  
Genetic Recombination ◽  
Holliday Junctions ◽  
The Novel ◽  
E Coli ◽  
The Past ◽  
Endonucleolytic Cleavage ◽  
Insight Into ◽  
Made In

Over the past three or four years, great strides have been made in our understanding of the proteins involved in recombination and the mechanisms by which recombinant molecules are formed. This review summarizes our current understanding of the process by focusing on recent studies of proteins involved in the later steps of recombination in bacteria. In particular, biochemical investigation of the in vitro properties of the E. coli RuvA, RuvB and RuvC proteins have provided our first insight into the novel molecular mechanisms by which Holliday junctions are moved along DNA and then resolved by endonucleolytic cleavage.

Recent progress in the freeze-etching technique

1971 ◽  
Vol 261 (837) ◽  
pp. 121-131 ◽  
Keyword(s):  
High Vacuum ◽  
Molecular Size ◽  
Etching Technique ◽  
Structural Distortions ◽  
Shadow Casting ◽  
Structural Details ◽  
Freeze Etching ◽  
The One ◽  
Insight Into ◽  
Made In

The freeze-etching technique must be improved if structures at the molecular size level are to be seen. The limitations of the technique are discussed here together with the progress made in alleviating them. The vitrification of living specimens is limited by the fact that very high freezing rates are needed. The critical freezing rate can be lowered on the one hand by the introduction of antifreeze agents, on the other hand by the application of high hydrostatic pressure. The fracture process may cause structural distortions in the fracture face of the frozen specimen. The ‘double-replica’ method allows one to evaluate such artefacts and provides an insight into the way that membranes split. During etching there exists the danger of contaminating the fracture faces with condensable gases. Because of specimen temperatures below —110 °C, special care has to be taken in eliminating water vapour from the high vacuum. An improvement in coating freeze-etched specimens has resulted from the application of electron guns for evaporation of the highest melting-point metals. If heat transfer from gun to specimen is reduced to a minimum, Pt, Ir, Ta, W and C can be used for shadow casting. Best results are obtained with Pt-C and Ta-W . With the help of decoration effects Pt-C shadow castings give the most information about the fine structural details of the specimen.

scholarly journals “It’s Not Just a Simple Meal. It’s So Much More”: Interactions Between Meals on Wheels Clients and Drivers

2018 ◽  
Vol 39 (2) ◽  
pp. 151-158 ◽  
Author(s):  
Kali S. Thomas ◽  
Emily A. Gadbois ◽  
Renee R. Shield ◽  
Ucheoma Akobundu ◽  
Andrea M. Morris ◽  
...  
Keyword(s):  
The United States ◽  
Case Managers ◽  
Qualitative Research Study ◽  
Personal Benefit ◽  
Meals On Wheels ◽  
Clear Insight ◽  
Additional Support ◽  
Insight Into ◽  
Made In ◽  
Meal Delivery

Background and Objectives: Meals on Wheels (MOW) programs provide home-delivered meals to over 1.5 million older adults; yet, very little is known about the drivers who make meal deliveries possible. Specifically, we do not have clear insight into their interaction with clients or the benefits that they may receive through their service. The objective of this article is to describe the characteristics of MOW drivers, the interactions among drivers and clients, and the benefits of the program to both. Research Design and Method: This qualitative research study reports on interviews with 84 MOW staff (leadership, case managers/client assessors, volunteer coordinators) and drivers at six geographically and operationally distinct programs across the United States. Results: Qualitative analysis of the interviews with MOW staff and drivers revealed the following key themes: (a) clients have multiple vulnerabilities; (b) clients appear to derive social, as well as nutritional benefit from receiving meals; (c) drivers report they provide additional support to their clients beyond delivering the meal; (d) social bonds between drivers and clients were reported to strengthen over time; (e) drivers claim that they, too, derive validation and personal benefit through their meal delivery. Discussion and Implications: This research highlights the significant contributions that meal delivery drivers made in the lives of MOW clients beyond the actual meal itself. This research also spotlights the perceived benefits experienced by the drivers and points to the importance of conducting further research to determine the effects of meal delivery on client and drivers’ outcomes, more broadly.

scholarly journals The Communication of Ideas across Subfields in Political Science

2014 ◽  
Vol 47 (02) ◽  
pp. 468-476 ◽  
Author(s):  
Erin R. Graham ◽  
Charles R. Shipan ◽  
Craig Volden
Keyword(s):  
Network Analysis ◽  
International Relations ◽  
Political Science ◽  
Comparative Politics ◽  
Diffusion Processes ◽  
Methodological Approach ◽  
Journal Articles ◽  
Insight Into ◽  
Shed Light ◽  
Levels Of Integration

ABSTRACTWhat factors inhibit or facilitate cross-subfield conversations in political science? This article draws on diffusion scholarship to gain insight into cross-subfield communication. Diffusion scholarship represents a case where such communication might be expected, given that similar diffusion processes are analyzed in American politics, comparative politics, and international relations. We identify nearly 800 journal articles published on diffusion within political science between 1958 and 2008. Using network analysis we investigate the degree to which three “common culprits”—terminology, methodological approach, and journal type—influence levels of integration. We find the highest levels of integration among scholars using similar terms to describe diffusion processes, sharing a methodological approach (especially in quantitative scholarship), and publishing in a common set of subfield journals. These findings shed light on when cross-subfield communication is likely to occur with ease and when barriers may prove prohibitive.

scholarly journals Closing up onto our sun: solar imaging

2020 ◽  
Vol 240 ◽  
pp. 07011
Author(s):  
Kushagra Shrivastava ◽  
Keith Wen Kai Chia ◽  
Kang Jun Wong ◽  
Alfred Yong Liang Tan ◽  
Hwee Tiang Ning
Keyword(s):  
Solar Activity ◽  
The Sun ◽  
Research Needs ◽  
Large Numbers ◽  
Wide Range ◽  
Future Science ◽  
Insight Into ◽  
Term Data ◽  
Made In

Solar activity research provides insight into the Sun’s past, future (Science Daily, 2018). The solar activity includes observations of large numbers of intense sunspots, flares, and other phenomena; and demands a wide range of techniques and measurements on the observations. This research needs long term data collection before critical analyses can occur, to generate meaningful learning and knowledge. In this project, we will use solar imaging to make observations of solar activity, and take our baby steps to make contributions in citizen science. Observations will be made in 3 wavelengths to gain a more thorough analysis by looking at different perspectives of the Sun, namely H-Alpha, Calcium-K, and white light.

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