scholarly journals Multi-Vortex Regulation for Efficient Fluid and Particle Manipulation in Ultra-Low Aspect Ratio Curved Microchannels

Micromachines ◽  
2021 ◽  
Vol 12 (7) ◽  
pp. 758
Author(s):  
Shaofei Shen ◽  
Xin Wang ◽  
Yanbing Niu
Keyword(s):  
Aspect Ratio ◽  
Tumor Cells ◽  
Clinical Applications ◽  
Cancer Diagnostics ◽  
Fluid Mixing ◽  
Particle Manipulation ◽  
Low Aspect Ratio ◽  
Mixing Effects ◽  
Dean Vortex ◽  
Helical Vortex

Inertial microfluidics enables fluid and particle manipulation for biomedical and clinical applications. Herein, we developed a simple semicircular microchannel with an ultra-low aspect ratio to interrogate the unique formations of the helical vortex and Dean vortex by introducing order micro-obstacles. The purposeful and powerful regulation of dimensional confinement in the microchannel achieved significantly improved fluid mixing effects and fluid and particle manipulation in a high-throughput, highly efficient and easy-to-use way. Together, the results offer insights into the geometry-induced multi-vortex mechanism, which may contribute to simple, passive, continuous operations for biochemical and clinical applications, such as the detection and isolation of circulating tumor cells for cancer diagnostics.

scholarly journals Numerical Study of Multivortex Regulation in Curved Microchannels with Ultra-Low-Aspect-Ratio

Micromachines ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 81
Author(s):  
Shaofei Shen ◽  
Mengqi Gao ◽  
Fangjuan Zhang ◽  
Yanbing Niu
Keyword(s):  
Aspect Ratio ◽  
Chemical Engineering ◽  
Numerical Study ◽  
Channel Height ◽  
Materials Synthesis ◽  
Inertial Microfluidics ◽  
Low Aspect Ratio ◽  
Curved Channels ◽  
Dean Vortex ◽  
Helical Vortex

The field of inertial microfluidics has been significantly advanced in terms of application to fluid manipulation for biological analysis, materials synthesis, and chemical process control. Because of their superior benefits such as high-throughput, simplicity, and accurate manipulation, inertial microfluidics designs incorporating channel geometries generating Dean vortexes and helical vortexes have been studied extensively. However, existing technologies have not been studied by designing low-aspect-ratio microchannels to produce multi-vortexes. In this study, an inertial microfluidic device was developed, allowing the generation and regulation of the Dean vortex and helical vortex through the introduction of micro-obstacles in a semicircular microchannel with ultra-low aspect ratio. Multi-vortex formations in the vertical and horizontal planes of four dimension-confined curved channels were analyzed at different flow rates. Moreover, the regulation mechanisms of the multi-vortex were studied systematically by altering the micro-obstacle length and channel height. Through numerical simulation, the regulation of dimensional confinement in the microchannel is verified to induce the Dean vortex and helical vortex with different magnitudes and distributions. The results provide insights into the geometry-induced secondary flow mechanism, which can inspire simple and easily built planar 2D microchannel systems with low-aspect-ratio design with application in fluid manipulations for chemical engineering and bioengineering.

Development of an Ion Beam Probe System for Potential Measurement in the Low Aspect-Ratio Torus Experiment Device

2012 ◽  
Vol 132 (7) ◽  
pp. 567-573
Author(s):  
Hitoshi Tanaka ◽  
Shota Omi ◽  
Jun Katsuma ◽  
Yurie Yamamoto ◽  
Masaki Uchida ◽  
...  
Keyword(s):  
Aspect Ratio ◽  
Ion Beam ◽  
Potential Measurement ◽  
Low Aspect Ratio ◽  
Probe System ◽  
Experiment Device
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