scholarly journals Innovative 3D Microfluidic Tools for On-Chip Fluids and Particles Manipulation: From Design to Experimental Validation

Micromachines ◽  
2021 ◽  
Vol 12 (2) ◽  
pp. 104
Author(s):  
Sofia Zoupanou ◽  
Maria Serena Chiriacò ◽  
Iolena Tarantini ◽  
Francesco Ferrara
Keyword(s):  
Computer Aided Design ◽  
Three Dimensional ◽  
Liquid Composition ◽  
Fluorescent Nanoparticles ◽  
Lab On Chip ◽  
Essential Components ◽  
3D Architecture ◽  
Low Efficiency ◽  
On Chip ◽  
Good Transparency

Micromixers are essential components in lab-on-a-chip devices, of which the low efficiency can limit many bio-application studies. Effective mixing with automation capabilities is still a crucial requirement. In this paper, we present a method to fabricate a three-dimensional (3D) poly(methyl methacrylate) (PMMA) fluidic mixer by combining computer-aided design (CAD), micromilling technology, and experimental application via manipulating fluids and nanoparticles. The entire platform consists of three microfabricated layers with a bottom reservoir-shaped microchannel, a central serpentine channel, and a through-hole for interconnection and an upper layer containing inlets and outlet. The sealing process of the three layers and the high-precision and customizable methods used for fabrication ensure the realization of the monolithic 3D architecture. This provides buried running channels able to perform passive chaotic mixing and dilution functions, thanks to a portion of the pathway in common between the reservoir and serpentine layers. The possibility to plug-and-play micropumping systems allows us to easily demonstrate the feasibility and working features of our device for tracking the mixing and dilution performances of the micromixer by using colored fluids and fluorescent nanoparticles as the proof of concept. Exploiting the good transparency of the PMMA, spatial liquid composition and better control over reaction variables are possible, and the real-time monitoring of experiments under a fluorescence microscope is also allowed. The tools shown in this paper are easily integrable in more complex lab-on-chip platforms.

Fabrication of three-dimensional microstructures based on singled-layered SU-8 for lab-on-chip applications

2006 ◽  
Vol 127 (2) ◽  
pp. 228-234 ◽  
Author(s):  
Hui Yu ◽  
Oluwaseyi Balogun ◽  
Biao Li ◽  
T.W. Murray ◽  
Xin Zhang
Keyword(s):  
Three Dimensional ◽  
Lab On Chip ◽  
On Chip

scholarly journals Molecular motor-driven filament transport across three-dimensional, polymeric micro-junctions

2021 ◽  
Author(s):  
Cordula Reuther ◽  
Sönke Steenhusen ◽  
Christoph Meinecke ◽  
pradheebha surendiran ◽  
Aseem Salhotra ◽  
...  
Keyword(s):  
Molecular Motors ◽  
Molecular Motor ◽  
Three Dimensional ◽  
Two Dimensions ◽  
Transport Systems ◽  
Focal Volume ◽  
Lab On Chip ◽  
Glass Substrates ◽  
Organic Hybrid ◽  
On Chip

Abstract Molecular motor-driven filament systems have been extensively explored for biomedical and nanotechnological applications such as lab-on-chip molecular detection or network-based biocomputation. In these applications, filament transport conventionally occurs in two dimensions (2D), often guided along open, topographically and/or chemically structured channels which are coated by molecular motors. However, at crossing points of different channels the filament direction is less well determined and, though crucial to many applications, reliable guiding across the junction can often not be guaranteed. We here present a three-dimensional (3D) approach that eliminates the possibility for filaments to take wrong turns at junctions by spatially separating the channels crossing each other. Specifically, 3D junctions with tunnels and overpasses were manufactured on glass substrates by two-photon polymerization, a 3D fabrication technology where a tightly focused, femtosecond-pulsed laser is scanned in a layer-to-layer fashion across a photo-polymerizable inorganic-organic hybrid polymer (ORMOCER®) with µm resolution. Solidification of the polymer was confined to the focal volume, enabling the manufacturing of arbitrary 3D microstructures according to CAD data. Successful realization of the 3D junction design was verified by optical and electron microscopy. Most importantly, we demonstrated the reliable transport of filaments, namely microtubules propelled by kinesin-1 motors, across these 3D junctions without junction errors. Our results open up new possibilities for 3D functional elements in biomolecular transport systems, in particular their implementation in biocomputational networks.

Three-dimensional integrated circuits for lab-on-chip dielectrophoresis of nanometer scale particles

2007 ◽  
Author(s):  
Samuel J. Dickerson ◽  
Arnaldo J. Noyola ◽  
Steven P. Levitan ◽  
Donald M. Chiarulli
Keyword(s):  
Integrated Circuits ◽  
Three Dimensional ◽  
Nanometer Scale ◽  
Lab On Chip ◽  
On Chip

scholarly journals Fabrication of Three-Dimensional Microvalves of Internal Nested Structures Inside Fused Silica

Micromachines ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 43
Author(s):  
Chao Shan ◽  
Qing Yang ◽  
Hao Bian ◽  
Xun Hou ◽  
Feng Chen
Keyword(s):  
Three Dimensional ◽  
Fused Silica ◽  
Wet Etching ◽  
Hard Material ◽  
The Novel ◽  
Lab On Chip ◽  
Step Process ◽  
Spherical Structure ◽  
Nested Structures ◽  
On Chip

Nested structures inside the hard material play a pivotal role in the microfluidics systems, such as the microvalve and the micropump. In this article, we demonstrate a novel and facile method of fabricating nested structures inside the fused silica with a two-step process femtosecond laser wet etching (FLWE) process. Inside fused silica, a spherical structure was made with a diameter of nearly 80 µm in a square chamber. In addition, we designed a simple microvalve with this sphere controlling the current’s flow. The novel microvalve structure can be easily integrated into the functional microfluidics systems and will be widely applied in the Lab-on-chip (LOC) system.

Three-dimensional microfluidic structure embedded in photostructurable glass by femtosecond laser for lab-on-chip applications

2004 ◽  
Vol 79 (4-6) ◽  
pp. 815-817 ◽  
Author(s):  
K. Sugioka ◽  
M. Masuda ◽  
T. Hongo ◽  
Y. Cheng ◽  
K. Shihoyama ◽  
...  
Keyword(s):  
Femtosecond Laser ◽  
Three Dimensional ◽  
Lab On Chip ◽  
On Chip ◽  
Photostructurable Glass ◽  
Microfluidic Structure

Three-Dimensional Microfluidic Focusing With Surface Charge Patterning

2005 ◽  
Author(s):  
Jeffrey T. Coleman ◽  
David Sinton
Keyword(s):  
Surface Charge ◽  
Three Dimensional ◽  
Memory Storage ◽  
Surface Patch ◽  
Hydrodynamic Focusing ◽  
Cross Sectional ◽  
Lab On Chip ◽  
Surface Patches ◽  
Sectional Surface ◽  
On Chip

Electrokinetically-driven flow circulations resulting from heterogeneous surface patches have previously been employed to improve mixing in microchannels. Here, numerical simulations demonstrate local in-channel hydrodynamic focusing through the use of strategically-patterned surface charge. Presented first is the case of a single straight channel with an axially-localized cross-sectional surface patch (ring). The surface patch exhibits a zeta potential equal in magnitude to the native microchannel surface but opposite in sign. The unsteady species transport in the presence of the electrokinetically-induced circulations is modelled, and a mean residence time is quantified. In general, residence times indicate the potential application of these circulations to microfluidic-based memory storage. Next, an improved focusing process for pinched-injection is demonstrated that exploits non-uniform surface patches. Lastly, surface patches are applied to enhance stream focusing in the microfluidic cross geometry. It is demonstrated that with this technique three-dimensional hydrodynamic focusing can be achieved in a single planar microfluidic structure. In one case, the microfluidic fluid stream was constrained to the centre of the channel and focused to 12% of its original cross-sectional area. Extensions of this work are discussed, as are the microfabrication and surface modification processes required for lab-on-chip implementation of these numerically simulated processes.

Analysis and Simulation of a Micro Hydrocyclone Device for Particle Liquid Separation

2012 ◽  
Vol 134 (2) ◽  
Author(s):  
P. Bagdi ◽  
P. Bhardwaj ◽  
A. K. Sen
Keyword(s):  
Stokes Equations ◽  
Separation Efficiency ◽  
Three Dimensional ◽  
Navier Stokes ◽  
Group Model ◽  
Operational Parameters ◽  
Lab On Chip ◽  
Dimensional Group ◽  
Simulation Results ◽  
On Chip

This paper presents a three-dimensional simulation of a micro hydrocyclone for the separation of micron sized particles from liquid in a particulated sample. A theoretical analysis is performed to demonstrate the working principle of the micro hydrocyclone and develop design models. The geometry of the proposed device is designed based on the Bradley model, since it offers a lower cut-size, thus making it suitable for microfluidics applications. The operational parameters of the hydrocyclone are derived from a dimensional group model. The particle separation process inside the micro hydrocyclone is simulated by solving fluid flows using Navier-Stokes equations and particle dynamics using the Lagrangian approach in a Eulerean fluid. First, the numerical model is validated by comparing the simulation results with the experimental results for a macroscale hydrocyclone reported in the literature. Then, the micro hydrocyclone is simulated and the simulation results are presented and discussed in the context of the functioning of the micro hydrocyclone. Finally, the effects of inlet velocity, vortex finder diameter, particle size, and density on the separation efficiency are investigated. The proposed device can be easily integrated with micro-environments; thus, is suitable for lab-on-chip and microsystems development.

Three Dimensional Design and Unfolding Method of Sheet Metal Parts

2012 ◽  
Vol 532-533 ◽  
pp. 208-212
Author(s):  
Bo Sun ◽  
Hui Fang Zhang
Keyword(s):  
Sheet Metal ◽  
Computer Aided Design ◽  
Parametric Design ◽  
Plate Thickness ◽  
Three Dimensional ◽  
Second Development ◽  
Unfolding Model ◽  
Metal Parts ◽  
Sheet Metal Parts ◽  
Low Efficiency

Sheet metal parts are widely used in various fields of mechanical industry. Unfolding is the first process of sheet metal processing. Due to the traditional manual way of sheet metal parts with large labor intensity and low efficiency, so the mode of production of sheet metal parts must be improved for quality and efficiency. Along with the conditions of computer aided design and production needs of the sheet metal industry, sheet metal CAD system is proposed to establish. At present, sheet metal systems are mostly based on second development of three-dimensional software to set up. So this paper is based on UG for second development to establish the sheet metal system. This system concentrates the study of method of parameter design and automatic unfolding of sheet metal parts. Parametric design and unfolding model of sheet metal parts is accomplished through the establishment of unfolding model and write control program. The principles of parametric design and second development tools of UG are specifically discussed in this paper. Unfolding model is created through the establishment of the parameters and considering plate thickness.

Mask Design and Simulation: Computer Aided Design for Lab-on-Chip Application

2013 ◽  
Vol 832 ◽  
pp. 84-88
Author(s):  
Veeradasan Perumal ◽  
U. Hashim ◽  
Tijjani Adam
Keyword(s):  
Computer Aided Design ◽  
Biomedical Application ◽  
Microfluidic Channel ◽  
Research Attention ◽  
Lab On Chip ◽  
Mask Design ◽  
Computer Aided ◽  
On Chip ◽  
Aided Design ◽  
Mask Fabrication

A simple design and simulation of microwire, contact pad and microfluidic channel on computer aided design (CAD) for chrome mask fabrication are described.The integration of microfluidic and nanotechnology for miniaturized lab-on-chip device has received a large research attention due to its undisputable and widespread biomedical applications. For the development of a micro-total analytical system, the integration of an appropriate fluid delivery system to a biosensing apparatus is required. In this study, we had presented the new Lab-On-Chip design for biomedical application. AutoCAD software was used to present the initial design/prototype of this Lab-On-Chip device. The microfluidic is design in such a way, that fluid flow was passively driven by capillary effect. Eventually, the prototype of the microfluidics was simulated using Comsol Multiphysics software for design validation.The complete design upon simulation is then used for mask fabrication. Hence, three mask is fabricated which consist of microwire, contact pad and microfluidics for device fabrication using photolithography process.

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