scholarly journals Feasibility Study of an Automated Assembly Process for Ultrathin Chips

Micromachines ◽  
2020 ◽  
Vol 11 (7) ◽  
pp. 654
Author(s):  
Florian Janek ◽  
Ebru Saller ◽  
Ernst Müller ◽  
Thomas Meißner ◽  
Sascha Weser ◽  
...  

This paper presents a feasibility study of an automated pick-and-place process for ultrathin chips on a standard automatic assembly machine. So far, scientific research about automated assembly of ultrathin chips, with thicknesses less than 50 µm, is missing, but is necessary for cost-effective, high-quantity production of system-in-foil for applications in narrow spaces or flexible smart health systems applied in biomedical applications. Novel pick-and-place tools for ultrathin chip handling were fabricated and a process for chip detachment from thermal release foil was developed. On this basis, an adhesive bonding process for ultrathin chips with 30 µm thickness was developed and transferred to an automatic assembly machine. Multiple ultrathin chips aligned to each other were automatically placed and transferred onto glass and polyimide foil with a relative placement accuracy of ±25 µm.

Author(s):  
Dan O. Popa ◽  
Michael Deeds ◽  
Abiodun Fasoro ◽  
Heather Beardsley ◽  
Jeongsik Sin ◽  
...  

In this paper we describe two modular automated microassembly systems, along with a several packaging processes that have been integrated to produce reliable and cost-effective MOEMS devices. The automated and packaging systems consists of robotics such as pick and place, insertion and fastening, machine vision and controls, and processes such as die attach, solder reflow by laser, wire bonding and seam sealing. The target MOEMS devices are intended for applications requiring a minimum twenty year shelf-life.


2020 ◽  
Vol 26 (40) ◽  
pp. 5188-5204
Author(s):  
Uzair Nagra ◽  
Maryam Shabbir ◽  
Muhammad Zaman ◽  
Asif Mahmood ◽  
Kashif Barkat

Nanosized particles, with a size of less than 100 nm, have a wide variety of applications in various fields of nanotechnology and biotechnology, especially in the pharmaceutical industry. Metal nanoparticles [MNPs] have been synthesized by different chemical and physical procedures. Still, the biological approach or green synthesis [phytosynthesis] is considered as a preferred method due to eco-friendliness, nontoxicity, and cost-effective production. Various plants and plant extracts have been used for the green synthesis of MNPs, including biofabrication of noble metals, metal oxides, and bimetallic combinations. Biomolecules and metabolites present in plant extracts cause the reduction of metal ions into nanosized particles by one-step preparation methods. MNPs have remarkable attractiveness in biomedical applications for their use as potential antioxidant, anticancer and antibacterial agents. The present review offers a comprehensive aspect of MNPs production via top-to-bottom and bottom-to-top approach with considerable emphasis on green technology and their possible biomedical applications. The critical parameters governing the MNPs formation by plant-based synthesis are also highlighted in this review.


Author(s):  
B K A Ngoi ◽  
L E N Lim ◽  
S S G Lee ◽  
S W Lye

This paper proposes the construction of an energy envelope that can be used to advantage with the energy barrier method to analyse the natural resting aspect of engineering parts destined for automatic assembly. Unlike the energy barrier method, the energy envelope does not require any visualization of the projection of the energy barrier on the aspect of interest. The energy envelope is the three-dimensional topology of the changes in height of the centroid, as the part attempts changes of aspect. The paper describes how it may be computed in a CAD (computer aided design) solid modeller. The results of applying the energy envelope to prisms of square and cylindrical cross-sections are the same as those predicted by the energy barrier method. When extended to the analysis of a rectangular prism, the results were consistent with Boothroyd's dynamic solution and Boothroyd's experimental data. This conclusion is encouraging as there is no irrefutable evidence that the energy barrier method may be applied to the analysis of the rectangular prism.


2021 ◽  
Author(s):  
Rahat Nawaz ◽  
Sayed Tayyab Raza Naqvi ◽  
Batool Fatima ◽  
Nazia Zulfiqar ◽  
Muhammad Umer Farooq ◽  
...  

Abstract Nonwoven cotton fabric has been fabricated and designed for antibacterial applications using low cost and ecofriendly precursors. The treatment of fabric with alkali leads to formation of active sites. The surfaces were dip coated with silver nanaoparticles and chitosan. The surface was chlorinated in next step to transform amide (N-H) groups in chitosan into N-halamine (N-Cl). The modified and unmodified surfaces of the nonwoven cotton fabric have been characterized by FTIR, SEM, and XRD. The active chlorine loading is measured with iodine/ sodium thiosulphate. The antimicrobial activity and cell toxicity assay were carried out with and without modifications of nonwoven cotton fabric. The antimicrobial efficacies of loaded fabric were evaluated against four bacterial species (Micrococcus lutes, Staphylococcus aurea, Enterobacter aerogenes, and E.coli). It was found that modified fabric exhibited superior efficiency against gram-positive and gram-negative bacterial strains as compared to their bulk counterparts upon exposure without destroying and affecting fabric nature. The overall process is economical for commercial purposes. The modified fabric can be used for antimicrobial, health, and food packaging industries, and in other biomedical applications.


2019 ◽  
Vol 36 (1) ◽  
pp. e10.1-e10
Author(s):  
Matthew Jones ◽  
Helen Snooks ◽  
Jenna Bulger ◽  
Alan Watkins ◽  
Chris Moore ◽  
...  

BackgroundOpioids such as heroin kill more people worldwide than any other drug. Death rates associated with opioid poisoning in the UK are at record levels. Naloxone is an opioid agonist which can be distributed in take home ‘kits’. This intervention is known as Take Home Naloxone (THN).MethodsWe propose to carry out a randomised controlled feasibility trial (RCT) of THN distributed in emergency settings clustered by Emergency Department (ED) catchment area, and local ambulance service; with anonymised linked data outcomes. This will include distribution of THN by paramedics and ED staff to patients at risk of opioid overdose. Existing linked data will be used to develop a discriminant function to retrospectively identify people at high risk of overdose death based on observable predictors of overdose to include in outcome follow up.ResultsWe will gather outcomes up to one year including; deaths (and drug related); emergency admissions; intensive care admissions; ED attendances (and overdose related); 999 attendances (and for overdose); THN kits issued; and NHS resource usage. We will agree progression criteria following consultation with research team members related to sign up of sites; successful identification and provision of THN to eligible participants; successful follow up of eligible participants and opioid decedents; adverse event rate; successful data matching and data linkage; and retrieval of outcomes within three months of projected timeline.ConclusionsTHN programmes are currently run by some drug services in the UK. However, saturation is low. There has been a lack of experimental research in to THN, and so questions remain: Does THN reduce deaths? Are there unforeseen harms associated with THN? Is THN cost effective? This feasibility study will establish whether a fully powered cluster RCT can be used to answer these questions.


2017 ◽  
Vol 2017 (1) ◽  
pp. 000569-000575 ◽  
Author(s):  
André Cardoso ◽  
Raquel Pinto ◽  
Elisabete Fernandes ◽  
Steffen Kroehnert

Abstract Due to its versatility for high density, heterogeneous integration, Wafer Level Fan Out (WLFO) packaging has recently seen a tremendous growth in a broad array of applications, from telecommunications and automotive, to optical and environmental sensing, while addressing the challenges of the next big wave of the Internet of Things (IoT). In this context, WLFO is continuously being challenged to include new families of MEMS/NEMS/MOEMS sensors, low thermal budget devices and biochips with microfluidics for biomedical applications. Recent developments in WLFO technology by NANIUM [1] demonstrated the implementation of a keep-out-zone (KOZ) mechanism intended to 1st) protect sensitive sensor areas during the backend processing of WLFO wafers and 2nd) create open zones on the Re-Distribution Layers (RDL). This way, the KOZ mechanism provides a physical, direct path from the embedded device to the environment. This is a necessary feature for environment sensing (e.g., pressure) or to create optical paths free of dielectric and protected from the harsh chemistry steps of the WLFO process. This paper describes new developments on KOZ, implemented with SU-8 photoresist as a WLFO dielectric, whose application is a novelty in the WLFO platform. The use of SU-8 and the KOZ with it, addresses some gaps of the current WLFO technology towards the integration of chips with bio-sensitive areas and sensors with low thermal budget. Due to its well-known bio-compatibility and inert behavior, SU-8 can be used as a neutral dielectric to be in direct contact to target fluids (e.g., sera, blood). Also, due to its low curing temperature, SU-8 allows a very low temperature WLFO process and thus the embedding of temperature-limited devices that have been outside the WLFO realm, for example, magneto-resistive or magnetic-spin sensor chips, which degrades its performance above 160°C. More interestingly, SU-8 exhibits a particular non-conformal behavior, which creates very smooth surfaces even over the mildly rough mold compound area of a fan-out package. Adding to this, SU-8 is readily available in the market in a wide range of thicknesses, spanning from 0.5 μm to >100 μm, and further allowing multiple spin coatings to build thick layers. Thus, SU-8 can provide smooth and deep enough channels for microfluidic flow over the chip sensing areas and, at the same time, provide the necessary layer thickness discrimination for the KOZ mechanism. Combining these features, the SU-8 layers in WLFO can play the triple role of 1) RDL dielectric insulation, 2) KOZ mechanism and 3) embedded microfluidic channels as part of the RDL. In summary, besides the unprecedented use of SU-8 in WLFO packaging, KOZ implementation on SU-8 provides a true, attainable bridge between WLFO and integrated microfluidic applications, for biosensing and biomedical applications in general. Outlooking the potentialities of such a merge, a Fan-Out package can embed several chips interconnected by RDL lines, as it currently allows, and also connected by microfluidic channel for multi-point, multi-function biosensing, constituting a true Lab-on-Package, cost-effective solution. Instead of building all sensing areas and microfluidic channels over a large silicon (Si) chip, this solution builds the feed-in, feed-out areas of the microfluidic channel over the inexpensive fan-out area, minimizing the sensing chip area, with the consequent front-end cost reduction.


Author(s):  
LATIF MS ◽  
ABBAS S ◽  
KORMIN F ◽  
MUSTAFA MK

The use of metal nanoparticles (MNPs) in various fields is increasing day-by-day leading to a genuine concern about the issues related to their environmental and biological safety. The major approaches for the synthesis of NPs include physical and chemical methods which are expensive and hazardous to health in addition to being toxic to the environment. This review highlights the potential of plant extracts to carry out the synthesis of MNPs with a special emphasis on the role of flavonoids in nanosynthesis. This green and clean approach have been actively utilized in recent years as an alternative to conventional hazardous approaches. It has proved as cost-effective, non-toxic, less time and labor consuming, efficient, and eco-friendly method for the synthesis of MNPs with specific biological actions. This review also focuses on the role of polyphenols, including the flavonoids as bioreductants of metal salts for the synthesis of NPs along with their biomedical applications. Various examples of the MNPs, along with their biological actions, have also been summarized.


2020 ◽  
Vol 1010 ◽  
pp. 579-583
Author(s):  
Nor Atiqah Syafinaz Mohd Pu'ad ◽  
Amirul Faiz Abdul Latif ◽  
Nurfarah Diyana Ramli ◽  
Mimi Suliza Muhamad ◽  
Hasan Zuhudi Abdullah ◽  
...  

Current biomedical field demands intensive research on cost-effective and high availability materials to fulfil its various applications. Owing to its similar characteristic to human bone, biological hydroxyapatite (HAp) has been used as an alternative in bone replacement and implantation. In this study, biological HAp was extracted from bovine bones via calcination. Powders calcined at 700 °C and 900 °C showed the presence of HAp. The FESEM analysis shows that the irregular morphology emerged and the size was increasing as the calcination temperature increased. By increasing the temperature of 1100 °C, β-TCP started to develop and influenced the ratio of Ca/P. At 900 °C, the Ca/P ratio obtained was 1.70, and closest to the theoretical ratio of Ca/P. The presences of trace elements like Ca, Mg, Sr Na, K and Zn in all samples are proved via EDS analysis, and these elements help to enhance the bioactivity hence make it a good alternative in biomedical applications.


Sensors ◽  
2020 ◽  
Vol 20 (16) ◽  
pp. 4439
Author(s):  
Vladislav Batshev ◽  
Alexander Machikhin ◽  
Grigoriy Martynov ◽  
Vitold Pozhar ◽  
Sergey Boritko ◽  
...  

Optical biomedical imaging in short wave infrared (SWIR) range within 0.9–1.7 μm is a rapidly developing technique. For this reason, there is an increasing interest in cost-effective and robust hardware for hyperspectral imaging data acquisition in this range. Tunable-filter-based solutions are of particular interest as they provide image processing flexibility and effectiveness in terms of collected data volume. Acousto-optical tunable filters (AOTFs) provide a unique set of features necessary for high-quality SWIR hyperspectral imaging. In this paper, we discuss a polarizer-free configuration of an imaging AOTF that provides a compact and easy-to-integrate design of the whole imager. We have carried out image quality analysis of this system, assembled it and validated its efficiency through multiple experiments. The developed system can be helpful in many hyperspectral applications including biomedical analyses.


Fluids ◽  
2018 ◽  
Vol 3 (3) ◽  
pp. 57 ◽  
Author(s):  
Arzu Özbey ◽  
Mehrdad Karimzadehkhouei ◽  
Hossein Alijani ◽  
Ali Koşar

Inertial Microfluidics offer a high throughput, label-free, easy to design, and cost-effective solutions, and are a promising technique based on hydrodynamic forces (passive techniques) instead of external ones, which can be employed in the lab-on-a-chip and micro-total-analysis-systems for the focusing, manipulation, and separation of microparticles in chemical and biomedical applications. The current study focuses on the focusing behavior of the microparticles in an asymmetric curvilinear microchannel with curvature angle of 280°. For this purpose, the focusing behavior of the microparticles with three different diameters, representing cells with different sizes in the microchannel, was experimentally studied at flow rates from 400 to 2700 µL/min. In this regard, the width and position of the focusing band are carefully recorded for all of the particles in all of the flow rates. Moreover, the distance between the binary combinations of the microparticles is reported for each flow rate, along with the Reynolds number corresponding to the largest distances. Furthermore, the results of this study are compared with those of the microchannel with the same curvature angle but having a symmetric geometry. The microchannel proposed in this study can be used or further modified for cell separation applications.


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