scholarly journals Drug Toxicity Evaluation Based on Organ-on-a-chip Technology: A Review

Micromachines ◽  
2020 ◽  
Vol 11 (4) ◽  
pp. 381 ◽  
Author(s):  
Ye Cong ◽  
Xiahe Han ◽  
Youping Wang ◽  
Zongzheng Chen ◽  
Yao Lu ◽  
...  
Keyword(s):  
Drug Toxicity ◽  
Academic Research ◽  
Toxicity Evaluation ◽  
Future Directions ◽  
Human Organ ◽  
Multiple Organs ◽  
Toxic Injury ◽  
Chip Technology ◽  
Promising Area ◽  
Organ On A Chip

Organ-on-a-chip academic research is in its blossom. Drug toxicity evaluation is a promising area in which organ-on-a-chip technology can apply. A unique advantage of organ-on-a-chip is the ability to integrate drug metabolism and drug toxic processes in a single device, which facilitates evaluation of toxicity of drug metabolites. Human organ-on-a-chip has been fabricated and used to assess drug toxicity with data correlation with the clinical trial. In this review, we introduced the microfluidic chip models of liver, kidney, heart, nerve, and other organs and multiple organs, highlighting the application of these models in drug toxicity detection. Some biomarkers of toxic injury that have been used in organ chip platforms or have potential for use on organ chip platforms are summarized. Finally, we discussed the goals and future directions for drug toxicity evaluation based on organ-on-a-chip technology.

scholarly journals A Decade of Organs-on-a-Chip Emulating Human Physiology at the Microscale: A Critical Status Report on Progress in Toxicology and Pharmacology

Micromachines ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 470
Author(s):  
Mario Rothbauer ◽  
Barbara E.M. Bachmann ◽  
Christoph Eilenberger ◽  
Sebastian R.A. Kratz ◽  
Sarah Spitz ◽  
...  
Keyword(s):  
Academic Research ◽  
Basic Research ◽  
In Vitro Models ◽  
Status Report ◽  
Chip Technology ◽  
Organ Systems ◽  
Future Drug ◽  
Pharmacology And Toxicology ◽  
Organ On A Chip

Organ-on-a-chip technology has the potential to accelerate pharmaceutical drug development, improve the clinical translation of basic research, and provide personalized intervention strategies. In the last decade, big pharma has engaged in many academic research cooperations to develop organ-on-a-chip systems for future drug discoveries. Although most organ-on-a-chip systems present proof-of-concept studies, miniaturized organ systems still need to demonstrate translational relevance and predictive power in clinical and pharmaceutical settings. This review explores whether microfluidic technology succeeded in paving the way for developing physiologically relevant human in vitro models for pharmacology and toxicology in biomedical research within the last decade. Individual organ-on-a-chip systems are discussed, focusing on relevant applications and highlighting their ability to tackle current challenges in pharmacological research.

scholarly journals Mechanical Strain-Enabled Reconstitution of Dynamic Environment in Organ-on-a-Chip Platforms: A Review

Micromachines ◽  
2021 ◽  
Vol 12 (7) ◽  
pp. 765
Author(s):  
Qianbin Zhao ◽  
Tim Cole ◽  
Yuxin Zhang ◽  
Shi-Yang Tang
Keyword(s):  
Cell Culture ◽  
Shear Stress ◽  
Cultured Cells ◽  
Mechanical Strain ◽  
3D Cell Culture ◽  
Small Scale ◽  
Mechanical Stimuli ◽  
Human Organ ◽  
Organ On A Chip

Organ-on-a-chip (OOC) uses the microfluidic 3D cell culture principle to reproduce organ- or tissue-level functionality at a small scale instead of replicating the entire human organ. This provides an alternative to animal models for drug development and environmental toxicology screening. In addition to the biomimetic 3D microarchitecture and cell–cell interactions, it has been demonstrated that mechanical stimuli such as shear stress and mechanical strain significantly influence cell behavior and their response to pharmaceuticals. Microfluidics is capable of precisely manipulating the fluid of a microenvironment within a 3D cell culture platform. As a result, many OOC prototypes leverage microfluidic technology to reproduce the mechanically dynamic microenvironment on-chip and achieve enhanced in vitro functional organ models. Unlike shear stress that can be readily generated and precisely controlled using commercial pumping systems, dynamic systems for generating proper levels of mechanical strains are more complicated, and often require miniaturization and specialized designs. As such, this review proposes to summarize innovative microfluidic OOC platforms utilizing mechanical actuators that induce deflection of cultured cells/tissues for replicating the dynamic microenvironment of human organs.

scholarly journals Psychology and interviewing: what direction now in our quest for reliable information?

2011 ◽  
Vol 13 (2) ◽  
pp. 135-144 ◽  
Author(s):  
Gavin E. Oxburgh ◽  
Coral J. Dando
Keyword(s):  
Empirical Research ◽  
Academic Research ◽  
Psychological Theory ◽  
Investigative Interviewing ◽  
Future Directions ◽  
Content Type ◽  
The Impact ◽  
Emergent Theory ◽  
And Training ◽  
Do So

PurposeThe purpose of this paper is to discuss two distinct but interrelated areas, namely witness/victim and suspect interviewing, and to argue that both must continue to evolve, suggest how they might do so, and that this process must be driven by emergent theory and contemporary empirical research.Design/methodology/approachThe paper outlines the impact of psychological theory and empirical research to investigative interviewing in recent decades.FindingsIt is argued that in order to stay ahead of the game, the field of investigative interviewing (suspect and witness) must continue to evolve in such a manner that not only protects and fosters the important practitioner/academic relationship, but also ensures that future directions are driven by empirical research, with recourse to emergent theory.Originality/valueThe paper outlines the impact of psychological theory and empirical research on investigative interviewing and the consequent enhancement of the interviewing of both suspected offenders and witnesses. The paper demonstrates that working closely together academic research can make a difference, and influence law, policy decisions and training guidelines in order to improve practice.

scholarly journals Physiological and Disease Models of Respiratory System Based on Organ-on-a-Chip Technology

Micromachines ◽  
2021 ◽  
Vol 12 (9) ◽  
pp. 1106
Author(s):  
Di Wang ◽  
Ye Cong ◽  
Quanfeng Deng ◽  
Xiahe Han ◽  
Suonan Zhang ◽  
...  
Keyword(s):  
Respiratory Diseases ◽  
Solute Concentration ◽  
The Body ◽  
The Real ◽  
Growth State ◽  
Chip Technology ◽  
Organ On A Chip ◽  
And Function ◽  
Multiple Cells

The pathogenesis of respiratory diseases is complex, and its occurrence and development also involve a series of pathological processes. The present research methods are have difficulty simulating the natural developing state of the disease in the body, and the results cannot reflect the real growth state and function in vivo. The development of microfluidic chip technology provides a technical platform for better research on respiratory diseases. The size of its microchannel can be similar to the space for cell growth in vivo. In addition, organ-on-a-chip can achieve long-term co-cultivation of multiple cells and produce precisely controllable fluid shear force, periodically changing mechanical force, and perfusate with varying solute concentration gradient. To sum up, the chip can be used to analyze the specific pathophysiological changes of organs meticulously, and it is widely used in scientific research on respiratory diseases. The focus of this review is to describe and discuss current studies of artificial respiratory systems based on organ-on-a-chip technology and to summarize their applications in the real world.

scholarly journals The Roles of Long Noncoding RNAs HNF1α-AS1 and HNF4α-AS1 in Drug Metabolism and Human Diseases

2020 ◽  
Vol 6 (2) ◽  
pp. 24 ◽  
Author(s):  
Liming Chen ◽  
Yifan Bao ◽  
Suzhen Jiang ◽  
Xiao-bo Zhong
Keyword(s):  
Drug Metabolism ◽  
Drug Toxicity ◽  
Target Genes ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Future Directions ◽  
Protein Coding ◽  
Mirna Sponge ◽  
Current Review ◽  
And Function

Long noncoding RNAs (lncRNAs) are RNAs with a length of over 200 nucleotides that do not have protein-coding abilities. Recent studies suggest that lncRNAs are highly involved in physiological functions and diseases. lncRNAs HNF1α-AS1 and HNF4α-AS1 are transcripts of lncRNA genes HNF1α-AS1 and HNF4α-AS1, which are antisense lncRNA genes located in the neighborhood regions of the transcription factor (TF) genes HNF1α and HNF4α, respectively. HNF1α-AS1 and HNF4α-AS1 have been reported to be involved in several important functions in human physiological activities and diseases. In the liver, HNF1α-AS1 and HNF4α-AS1 regulate the expression and function of several drug-metabolizing cytochrome P450 (P450) enzymes, which also further impact P450-mediated drug metabolism and drug toxicity. In addition, HNF1α-AS1 and HNF4α-AS1 also play important roles in the tumorigenesis, progression, invasion, and treatment outcome of several cancers. Through interacting with different molecules, including miRNAs and proteins, HNF1α-AS1 and HNF4α-AS1 can regulate their target genes in several different mechanisms including miRNA sponge, decoy, or scaffold. The purpose of the current review is to summarize the identified functions and mechanisms of HNF1α-AS1 and HNF4α-AS1 and to discuss the future directions of research of these two lncRNAs.

International equity REITs: five major future directions

2019 ◽  
Vol 38 (1) ◽  
pp. 71-81
Author(s):  
David Parker
Keyword(s):  
Quantitative Research ◽  
Design Methodology ◽  
Academic Research ◽  
Future Directions ◽  
Content Type ◽  
Risk Return ◽  
Cognitive Risk ◽  
International Equity ◽  
Equity Reits ◽  
Practical Implications

Purpose The purpose of this paper is to analyze chapters from the recently published Routledge REITs Research Handbook to identify five major future directions for international equity REITs. Design/methodology/approach Literature review and critical analysis of chapters from the recently published Routledge REITs Research Handbook. Findings The five major future directions for international equity REITs are proposed to comprise an increasing focus on people and on cash flow rather than on property (with the cognitive risk attaching thereto), the changing nature of REITs as they respond to changes in society globally, the evolution of the global flagship REIT and the emergence of global regulation of REITs (particularly in the spheres of debt and leverage). Research limitations/implications While five major future directions for international equity REITs are identified which may have an impact on the risk/return profile, further research is required to determine which directions may be significant and which trivial and which may be independent and which interactive. Practical implications Identification of five major future directions for international equity REITs provides managers and promoters with guidance concerning potential areas of focus for future product development in the REIT sector. Originality/value While quantitative research concerning international equity REITS abounds, qualitative research is limited with little academic research undertaken into possible future directions for the sector.

scholarly journals Organoids-on-a-chip

Science ◽  
2019 ◽  
Vol 364 (6444) ◽  
pp. 960-965 ◽  
Author(s):  
Sunghee Estelle Park ◽  
Andrei Georgescu ◽  
Dongeun Huh
Keyword(s):  
Stem Cell ◽  
Production Control ◽  
Functional Characteristics ◽  
Chip Technology ◽  
Organ On A Chip ◽  
Technical Challenges ◽  
Self Organizing

Recent studies have demonstrated an array of stem cell–derived, self-organizing miniature organs, termed organoids, that replicate the key structural and functional characteristics of their in vivo counterparts. As organoid technology opens up new frontiers of research in biomedicine, there is an emerging need for innovative engineering approaches for the production, control, and analysis of organoids and their microenvironment. In this Review, we explore organ-on-a-chip technology as a platform to fulfill this need and examine how this technology may be leveraged to address major technical challenges in organoid research. We also discuss emerging opportunities and future obstacles for the development and application of organoid-on-a-chip technology.

scholarly journals Gold Nanowires/Fibrin Nanostructure as Microfluidics Platforms for Enhancing Stem Cell Differentiation: Bio-AFM Study

Micromachines ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 50 ◽  
Author(s):  
Hashemzadeh ◽  
Allahverdi ◽  
Ghorbani ◽  
Soleymani ◽  
Kocsis ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Stem Cell Differentiation ◽  
Physical Parameters ◽  
Gold Nanowires ◽  
Matrix Elasticity ◽  
Cell Chip ◽  
Chip Technology ◽  
Wide Range ◽  
Organ On A Chip

Organ-on-a-chip technology has gained great interest in recent years given its ability to control the spatio-temporal microenvironments of cells and tissues precisely. While physical parameters of the respective niche such as microchannel network sizes, geometric features, flow rates, and shear forces, as well as oxygen tension and concentration gradients, have been optimized for stem cell cultures, little has been done to improve cell-matrix interactions in microphysiological systems. Specifically, detailed research on the effect of matrix elasticity and extracellular matrix (ECM) nanotopography on stem cell differentiation are still in its infancy, an aspect that is known to alter a stem cell’s fate. Although a wide range of hydrogels such as gelatin, collagen, fibrin, and others are available for stem cell chip cultivations, only a limited number of elasticities are generally employed. Matrix elasticity and the corresponding nanotopography are key factors that guide stem cell differentiation. Given this, we investigated the addition of gold nanowires into hydrogels to create a tunable biointerface that could be readily integrated into any organ-on-a-chip and cell chip system. In the presented work, we investigated the matrix elasticity (Young’s modulus, stiffness, adhesive force, and roughness) and nanotopography of gold nanowire loaded onto fibrin hydrogels using the bio-AFM (atomic force microscopy) method. Additionally, we investigated the capacity of human amniotic mesenchymal stem cells (hAMSCs) to differentiate into osteo- and chondrogenic lineages. Our results demonstrated that nanogold structured-hydrogels promoted differentiation of hAMSCs as shown by a significant increase in Collagen I and II production. Additionally, there was enhanced calcium mineralization activity and proteoglycans formation after a cultivation period of two weeks within microfluidic devices.

scholarly journals BARRIERS AND FUTURE DIRECTIONS FOR SUFFICIENT ACADEMIC RESEARCH ON HOME MODIFICATION FOR OLDER ADULTS IN CHINA

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S249-S250
Author(s):  
Mengzhao Yan
Keyword(s):  
Older Adults ◽  
Academic Research ◽  
Well Being ◽  
Future Research ◽  
China National Knowledge Infrastructure ◽  
Future Directions ◽  
Home Modification ◽  
Knowledge Infrastructure ◽  
Current State ◽  
Systematical Review

Abstract Home modification has been perceived as an effective method to make current dwelling units more age-friendly and improve the well-being of older adults. In China, a country with an increasing number of older adults, home modification research is still in its infancy. By typing “适老化改造” (home modification for older adults) as a keyword for the theme of articles in China National Knowledge Infrastructure (CNKI), the most authoritative and comprehensive database for academic publication in China, only 158 related papers are found to be published until the end of 2017, among which the first was published in 2009. With an aim to determine the current state of home modification research in older adults and to determine what could be done to facilitate sufficient research on this topic, the present study conducted a systematical review of the 158 papers about home modification for older adults published in China between 2009 and 2017. Based on the systematical review, the present paper identifies four barriers to conducting this line of research and puts forward six practical suggestions for future research studies in this area so as to contribute to building age-friendly dwellings and promoting age-friendly China.

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